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Dive into the research topics where Sandro Provenzano is active.

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Featured researches published by Sandro Provenzano.


Rivista Urologia | 2013

Pilot study on predictive value of plasmatic levels of 9 angiogenetic biomarkers in selection of patients candidate to prostate biopsy

Vincenzo Serretta; Salvatore Scurria; Nino Dispensa; Gaetano Chiapparrone; Sandro Provenzano; Stefano Caruso; Giuseppe Bronte; Giuseppe Cicero; Antonio Russo

To reduce the number of negative prostate biopsies in patients with elevated PSA serum levels represents a major challenge in urological oncology. Angiogenetic factors might be involved in initial stages of prostate cancer and might represent useful tools in patients’ selection for prostate biopsy. The plasmatic levels of Angiopoietin-2, Follistatin, G-CSF, HGF, IL-8, Leptin, PDGF-BB, PECAM-1 and VEGF were measured by BioPlex immunoassay in patients undergoing prostate biopsy for palpable prostate nodule and/or elevated PSA levels (≥4 ng/mL). They were related with biopsy results. ROC curve analysis was exploited to test the diagnostic accuracy of each biomarker by AUC calculation. A potential cut-off level was computed. Fifty patients were entered. Median PSA was 6.8 ng/mL. A prostate nodule was palpable in 18 (36%) patients. The median number of biopsy cores was 12. Prostate cancer was detected in 25 (50%) and ASAP and PIN in 2 more patients (4%) respectively. Among the 9 considered biomarkers, only leptin showed an interesting diagnostic performance with an AUC of 0.781, at a cut-off value of 2.11 ng/mL, demonstrating a sensitivity of 78%, a specificity of 77% and a positive predictive value of 85%. Main limitations of our study are the exploratory design and the criteria adopted for patients’ selection determining a detection rate for prostate cancer above the usual range. Leptin only, in our preliminary study, shows promising diagnostic accuracy for the selection of patients candidate to prostate biopsy. Further studies are required to confirm its diagnostic value and its relation with BMI.


PLOS ONE | 2018

Mediterranean diet adherence and synergy with acute myocardial infarction and its determinants: A multicenter case-control study in Italy

Giuseppe La Torre; Rosella Saulle; Francesca Di Murro; Roberta Siliquini; Alberto Firenze; Massimo Maurici; Alice Mannocci; Vittoria Colamesta; Francesco Barillà; Fabio Ferrante; Luciano Agati; Massimiliano Chiarini; Annalisa Rosso; Renata Gili; Fabrizio Bert; Sandro Provenzano; Clara Ferrara; Valentina Bonanno; Mariacarmela Ferraro; Aldo Marsico; Gerardo De Carolis; Sara Cimino; Valentina Petronilli; Francesco Cicogna

Background Cardiovascular diseases are the leading causes of mortality and morbidity in Western countries. The possible synergistic effect of poor adherence to a Mediterranean diet (MD) and other risk factors for acute myocardial infarction (AMI) such as hypertension, cholesterol, ever smoker, BMI> 25, diabetes, has not been deeply studied. Design Case-control study. Methods Patients with first AMI and controls from four tertiary referral Italian centers were screened for enrolment. Dietary information was collected through a questionnaire and a MD adherence score was calculated. Physical activity and smoking habits were also registered. The Synergy Index was calculated according to Rothman. Results 127 cases and 173 controls were enrolled. The analysis was conducted using a dichotomous variable for the MD score with values ≥7 representing good adherence. Multivariate analysis showed the following variables associated to AMI: ever smoker (OR = 2.08), diabetes (OR = 1.42), hypertension (OR = 2.08), hypercholesterolemia (OR = 2.47), BMI> 25 (OR = 1.99), while a protective effect emerged both in subjects scoring > 7 on the MD score (OR = 0.55) and in subjects resident of Southern Italy (OR = 0.38). A synergistic effect does exist between poor adherence to the MD and the following risk factors: hypertension, hypercholesterolemia, BMI >25, diabetes and being a resident in central and northern Italy. Conclusion Synergy between heart disease risk factors and MD underlines the need to enlarge the list of known modifiable cardiovascular risk factors to include and promote adherence to Mediterranean dietary habits.


Mental Illness | 2018

Onset of depressive symptomatology in a sample of university students

Omar Enzo Santangelo; Sandro Provenzano; Dario Piazza; Alberto Firenze

The aim of the study was to evaluate depressive symptomatology within the student population of the University of Palermo (Italy). An anonymous online questionnaire was provided to the students of the University of Palermo. The first section investigated demographic and social data, while in the second section the QIDS-SR16 (Quick Inventory of Depressive Symptomatology Self-Report) test was administered. 539 students (68.3% female) gave informed consent and completed the questionnaire. Considering as a dependent variable: Depressive symptomatology moderate-severe-very severe, the statistically significant independent variables associated are I don’t live with my family (aOR 1.63, 95% CI 1.01-2.63, P=0.043), I currently smoke (aOR 1.55, 95% CI 1.01-2.39, P=0.048) and Low perceived health status (aOR 4.14, 95% CI 2.73-6.28, P<0.001). Smoking is associated with an increased risk of developing a high-grade depressive symptomatology. Family plays a crucial role in decreasing the risk of moderate, severe or very severe symptoms.


Rivista Di Psichiatria | 2018

Ansia, depressione e consumo rischioso di alcol in un campione di studenti universitari

Omar Enzo Santangelo; Sandro Provenzano; Alberto Firenze


Epidemiology, biostatistics, and public health | 2018

Comparison between adenosine triphosphate bioluminescence and aerobic colony count to assess surface sanitation in the hospital environment

Daniele Domenico Raia; Lucia Cannova; Sandro Provenzano; Omar Enzo Santangelo; Dario Piazza; Enrico Alagna; Valentina Bonanno; L Aprea; Alberto Firenze


Annali dell'Istituto Superiore di Sanità | 2018

Knowledge of sexually transmitted infections and sex-at-risk among Italian students of health professions. Data from a one-month survey

Omar Enzo Santangelo; Sandro Provenzano; Alberto Firenze


Clinica Terapeutica | 2017

Nuove modalità di didattica come strumenti di sanità pubblica: Hackathon Public Health

Alberto Firenze; Sandro Provenzano; Omar Enzo Santangelo; E. Alagna; D. Piazza; M.V. Torregrossa


III EDIZIONE Giornate degli Specializzandi in Igiene e Medicina Preventiva | 2015

Can immigrants transmit infectious diseases to general population? A survey of high school students in western Sicily.

Alberto Firenze; Vincenzo Restivo; Valentina Bonanno; Sandro Provenzano


48° Congresso Nazionale S.It.I. - Alimentare la salute | 2015

IVIAGGIO: L’APP DEL VIAGGIARE, VIAGGIANDO IN SICUREZZA.

Alberto Firenze; Vincenzo Restivo; Valentina Bonanno; Sandro Provenzano; Vincenzo Giallombardo


48° Congresso Nazionale S.It.I. - Alimentare la salute | 2015

ENTE REGIONALE PER IL DIRITTO ALLO STUDIO (ERSU): MENSE GOURMET?

Alberto Firenze; Vincenzo Restivo; Valentina Bonanno; Sandro Provenzano; Daniele Domenico Raia

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L Aprea

University of Palermo

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