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Dive into the research topics where Sanford E. Warren is active.

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Featured researches published by Sanford E. Warren.


The American Journal of Medicine | 1980

Does a renal vasodilator system mediate racial differences in essential hypertension

Sanford E. Warren; Daniel T. O'Connor

Clinical and epidemiologic data support the contention that black people have a higher incidence and severity of essential hypertension than white people, a phenomenon which is likely due to genetic factors. Physiologic profiles in such patients reveal a striking prevalence of low renin, volume-expanded hypertension, with an exaggerated propensity to sodium retention. A deficiency in the natriuretic, vasodilatory renal kallikrein-kinin system may explain these phenomena and may be of practical importance in the selection of therapy.


American Heart Journal | 1983

Autonomic and baroreflex function after captopril in hypertension

Sanford E. Warren; Daniel T. O'Connor; Irving M. Cohen

Absent reflex tachycardia with captopril therapy suggests blunting of circulatory reflexes, perhaps contributing to antihypertensive efficacy, and angiotensin converting enzyme inhibition may alter sympathetic function. Captopril effects on autonomic function were investigated in five severe hypertensive patients. Mean blood pressure fell in all patients (from 141 +/- 6 to 119 +/- 7 mm Hg, p less than 0.02) without orthostatic blood pressure fall or increase in heart rate (both p greater than 0.1) on captopril. Captopril did not alter baroreflex sensitivity as tested by amyl nitrile hypotension or phenylephrine hypertension (both p greater than 0.1). Comparison of these severely hypertensive patients to age matched normotensive control subjects did reveal markedly blunted baroreflex sensitivity in both the amyl nitrite test (by 89%, p less than 0.01) and the phenylephrine test (by 83%, p less than 0.01), suggesting that baseline blunting of baroreflex function may in part account for absence of reflex tachycardia. Captopril diminished the cardioacceleration after cold stress (from 61 +/- 38 to 23 +/- 43 msec, p less than 0.05) as well as the blood pressure fall after alpha-adrenergic blockade (from 46 +/- 13 to 24 +/- 9 mm Hg, p less than 0.05), suggesting diminished sympathetic stimulation of resistance vessels and decreased sympathetic participation in blood pressure maintenance, possibly at the prejunctional synaptic level. Four biochemical indices of sympathetic activity did not change. Thus captopril-treated patients had blunted reflex tachycardia, commensurate with blunted baroreflex function at baseline, and physiologic and pharmacologic evidence of diminished sympathetic activity was obtained with captopril therapy. Whether diminished sympathetic activity is involved in captoprils antihypertensive effect has not been determined.


JAMA | 1980

Hyperkalemia Resulting From Captopril Administration

Sanford E. Warren; Daniel T. O'Connor


JAMA | 1980

Hypernatremia in hepatic failure.

Sanford E. Warren; John A. Mitas; Aron R. Swerdlin


JAMA | 1979

Digoxin Overdose Limitations of Hemoperfusion-Hemodialysis Treatment

Sanford E. Warren; Darrell D. Fanestil


JAMA Internal Medicine | 1979

Clonidine and Propranolol Paradoxical Hypertension

Sanford E. Warren; Edward Ebert; Aron-Hirsz Swerdlin; Steven M. Steinberg; Richard A. Stone


Renal Failure | 1978

Recirculation: a uremic syndrome complicating the use of prosthetic arteriovenous fistulas for hemodialysis.

Sanford E. Warren; Daniel T. O'Connor; Steven M. Steinberg


American Heart Journal | 1982

Contrasting progression of mitral stenosis in Malayans versus American-born Caucasians.

B.C. Joswig; Matthew U. Glover; J.B. Handler; Sanford E. Warren; W.V.R. Vieweg


Catheterization and Cardiovascular Diagnosis | 1980

Quantitation of left ventricular wall motion in normal subjects: Comparison of various methods

Valmik Bhargava; Sanford E. Warren; W. V. R. Vieweg; Ralph Shabetai


JAMA | 1983

Renal failure and tubular dysfunction due to zomepirac therapy.

Sanford E. Warren; Coleman Mosley

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Irving M. Cohen

United States Department of Veterans Affairs

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Aron R. Swerdlin

Naval Medical Center San Diego

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Jeffrey B. Handler

Naval Medical Center San Diego

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John A. Mitas

University of California

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Peder M. Shea

Naval Medical Center San Diego

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Ralph Shabetai

United States Department of Veterans Affairs

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Richard A. Stone

University of Pennsylvania

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