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Publication
Featured researches published by Sang Kyu Woo.
Journal of Gene Medicine | 2011
Eun Wha Choi; Il Seob Shin; Hee Woo Lee; So Young Park; Ji Hyun Park; Mi Hyun Nam; Jong Sung Kim; Sang Kyu Woo; Eun Ji Yoon; Sung Keun Kang; Jeong Chan Ra; Hwa Young Youn; Sung Hwa Hong
Autoimmune thyroiditis is one of common organ‐specific autoimmune disease. The aim of this study was to observe the effect of adipose tissue derived mesenchymal stem cells (ATMSC) and CTLA4Ig gene‐transduced ATMSC on autoimmune thyroiditis.
Journal of Medical Case Reports | 2014
Soo Won Choi; Kwon Byong Park; Sang Kyu Woo; Sung Keun Kang; Jeong Chan Ra
IntroductionProgressive supranuclear palsy is a relentlessly progressive neurodegenerative disorder and is clinically characterized by parkinsonism. Adipose tissue-derived mesenchymal stem cells have recently demonstrated the possibility of treating neurological disorders. Therefore, autologous adipose tissue-derived mesenchymal stem cells transplantation can be an alternative method for treating progressive supranuclear palsy.Case presentationThis study was approved by the Korea Food and Drug Administration through the Emergency Use Investigational New Drug Application. A 71-year-old Asian man from South Korea with progressive supranuclear palsy was treated with five intravenous infusions (each time 2×108 cells) and four intrathecal infusions (each time 5×107 cells) with autologous adipose tissue-derived mesenchymal stem cells expanded under good manufacturing practice conditions. Clinical examinations were performed immediately before treatment and throughout the six months of follow-up. The tests included: 1) Progressive Supranuclear Palsy Rating Scale; 2) Berg Balance Scale; 3) Korean Mini Mental State Examination; 4) Modified Barthel Index; 5) grip strength; 6) Box and Block Test; and 7) Nine-Hole Peg Test.The Progressive Supranuclear Palsy Rating Scale results gradually decreased, and the clinical rating scale scores of the Berg Balance Scale, Korean Mini Mental State Examination, and Modified Barthel Index gradually increased. Grip strength was maintained. Performance in the Box and Block Test and Nine-Hole Peg Test improved after adipose tissue-derived mesenchymal stem cells treatment compared to baseline throughout the six months of follow-up. Except for the intermittent mild fever and transient elevated blood pressure, the treatment of our patient with progressive supranuclear palsy with autologous adipose tissue-derived mesenchymal stem cells showed no significant adverse events, and delayed the progression of neurological deficits by achieving functional improvement in the follow-up period.ConclusionsThese results are encouraging and hopeful for further studies in patients with progressive supranuclear palsy using autologous adipose tissue-derived mesenchymal stem cells as a safe and effective therapy. This case report is the first known study of adipose tissue-derived mesenchymal stem cells safely delaying the progression of progressive supranuclear palsy with functional improvement during the follow-up period.
Archive | 2008
Jeong Chan Ra; Il Seob Shin; Sung Keun Kang; Sang Kyu Woo
Archive | 2010
Jeong Chan Ra; Sung Keun Kang; Sang Kyu Woo; Hwa Young Youn; Hee Woo Lee; Kyoung Won Seo
Archive | 2010
Jeong Chan Ra; Sung Keun Kang; Sang Kyu Woo; Mi Ae Kim; Eun Ji Yoon
Archive | 2010
Hyung Suk Bae; Sung Keun Kang; Il Seob Shin; Sang Kyu Woo; Yun Jung Kim; Mi Ae Kim; Jeong Chan Ra
Archive | 2010
Jeong Chan Ra; 라정찬; Sung Keun Kang; 강성근; Sang Kyu Woo; 우상규; Mi Ae Kim; 김미애; Eun Ji Yoon; 윤은지
Archive | 2010
Jeong Chan Ra; 라정찬; Sung Keun Kang; 강성근; Sang Kyu Woo; 우상규; Hwa Young Youn; 윤화영; Hee Woo Lee; 이희우; Kyoung Won Seo; 서경원
Archive | 2010
Hyung Suk Bae; 배형석; Sung Keun Kang; 강성근; Il Seob Shin; 신일섭; Sang Kyu Woo; 우상규; Yun Jung Kim; 김윤정; Mi Ae Kim; 김미애; Jeong Chan Ra; 라정찬
Archive | 2010
Jeong Chan Ra; 라정찬; Sung Keun Kang; 강성근; Sang Kyu Woo; 우상규; Hwa Young Youn; 윤화영; Hee Woo Lee; 이희우; Kyoung Won Seo; 서경원