Sanjeev Kumar Jain

I am the Best-Am I?

1. Hassold T, Hall H, Hunt P. The origin of human aneuploidy: Where we have been,where we are going. Hum Mol Genet. 2007;16(2):203–208. 2. Vogt E, Kirsch-Volders M, Parry J, Eichenlaub-Ritter U. Spindle formation, chromosome segregation and the spindle Available literature of review confirms, Chromosome Segregation Errors (CSE)as the prime cause of pregnancy loss in aging females.1 Amongst other well known potential causes of pregnancy loss in advanced age (35 yr onwards) Bub1(budding uninhibited by benzimidazole), is proved to be the leading cause. Most common chromosomal segregation error is aneuploidy, during Oogenesis2 in advancing maternal age.3 Disturbed functioning of (Spindle Assembly Checkpoint) SAC leads to aneuploidy.4 The SAC restricts the abnormal drifting of sister chromatids and maintains accurate chromosomal segregation.5 Bub1 is the very important constituent of the (SAC). The (Bub1) is required for the efficient kinetochore localization. Depletion or absence of Bub1 leads to loss of chromatid cohesion.6,7