Santiago Morales

Attention Biases Towards and Away from Threat Mark the Relation between Early Dysregulated Fear and the Later Emergence of Social Withdrawal

Fearful temperament, mostly studied as behavioral inhibition (BI), has been extensively associated with social withdrawal in childhood and the later emergence of anxiety disorders, especially social anxiety disorder (SAD). Recent studies have characterized a distinct type of fearful temperament marked by high levels of fear in low threat situations – labeled dysregulated fear. Dysregulated fear has been related to SAD over and above risks associated with BI. However, the mechanism by which dysregulated fear is related to SAD has not been studied. Cognitive mechanisms, such as attentional bias towards threat, may be a possible conduit. We examined differences in attentional bias towards threat in six-year-olds who displayed a pattern of dysregulated fear at age two (N = 23) compared with children who did not display dysregulated fear (N = 33). Moreover, we examined the concurrent relation between attentional bias and social withdrawal. Results indicated that children characterized by dysregulated fear showed a significant bias away from threat, and that this bias was significantly different from the children without dysregulated fear, who showed no significant bias. Moreover, attentional bias towards threat was positively related to social withdrawal only for the dysregulated fear group. These results are discussed in consideration of the existing knowledge of attentional bias to threat in the developmental and pediatric anxiety literatures, as well as recent studies that find important heterogeneity in attentional bias.

Longitudinal associations between temperament and socioemotional outcomes in young children: The moderating role of RSA and gender

Temperament is an important predictor of socioemotional adjustment, such as externalizing and internalizing symptoms. However, there is not a one-to-one correspondence between temperamental predispositions and these outcomes, implying that other factors also contribute to the development of internalizing and externalizing problems. Self-regulation is believed to interact with temperament, and has been studied as a predictor for later socioemotional outcomes. Respiratory sinus arrhythmia (RSA) is a psychophysiological measure of self-regulation that has been studied as a moderator of risk. The primary aim of the present study was to test if RSA baseline and RSA reactivity would moderate the link between temperament and socioemotional outcomes. Mothers reported the temperament of their infants (20 months; N = 154), RSA was collected at 24- and 42-months, and mothers reported externalizing and internalizing behaviors at kindergarten entry. RSA baseline and RSA reactivity moderated the relation between exuberant temperament and externalizing behaviors. However, these results were only significant for girls, such that high RSA baseline and greater RSA suppression predicted more externalizing behaviors when exuberance was high. Fearful temperament predicted later internalizing behaviors, but no moderation was present. These results are discussed in light of recent evidence regarding gender differences in the role of RSA as a protective factor for risk.

A developmental neuroscience perspective on affect-biased attention

Highlights • We place affect-biased attention within a developmental neuroscience framework.• We suggest that affect-biased attention serves as a domain general mechanism.• Affect-biased attention broadly shapes socioemotional trajectories across development.• We review the developmental neurocognitive mechanisms of affect-biased attention.• A proposed model helps place affect-biased attention in a developmental context.

Temperament and Attention as Core Mechanisms in the Early Emergence of Anxiety

Anxiety is a pervasive, impairing, and early appearing form of psychopathology. Even when anxiety remits, children remain at a two- to threefold increased risk for the later emergence of a mood disorder. Therefore, it is imperative to identify and examine underlying mechanisms that may shape early emerging patterns of behavior that are associated with anxiety. One of the strongest and first visible risk factors is childhood temperament. In particular, children who are behaviorally inhibited or temperamentally shy are more likely to exhibit signs of anxiety by adolescence. However, not all shy children do so, despite the early risk. We know that attention mechanisms, particularly the presence of attention biases toward or away from threat, can play a critical role in the emergence of anxiety. The current chapter will bring together these separate lines of research to examine the ways in which attention can modulate the documented link between early temperament and later anxiety. In doing so, the chapter will highlight multiple levels of analysis that focus on the behavioral, cognitive, and neural mechanisms in the temperament-attention-anxiety network. The chapter will help identify both markers and mechanisms of risk, supporting future work aimed at improving theory and intervention by focusing on attention biases to environmental threat.

Maternal anxiety predicts attentional bias towards threat in infancy.

Although cognitive theories of psychopathology suggest that attention bias toward threat plays a role in the etiology and maintenance of anxiety, there is relatively little evidence regarding individual differences in the earliest development of attention bias toward threat. The current study examines attention bias toward threat during its potential first emergence by evaluating the relations between attention bias and known risk factors of anxiety (i.e., temperamental negative affect and maternal anxiety). We measured attention bias to emotional faces in infants (N = 98; 57 male) ages 4 to 24 months during an attention disengagement eye-tracking paradigm. We hypothesized that (a) there would be an attentional bias toward threat in the full sample of infants, replicating previous studies; (b) attentional bias toward threat would be positively related to maternal anxiety; and (c) attention bias toward threat would be positively related to temperamental negative affect. Finally, (d) we explored the potential interaction between temperament and maternal anxiety in predicting attention bias toward threat. We found that attention bias to the affective faces did not change with age, and that bias was not related to temperament. However, attention bias to threat, but not attention bias to happy faces, was positively related to maternal anxiety, such that higher maternal anxiety predicted a larger attention bias for all infants. These findings provide support for attention bias as a putative early mechanism by which early markers of risk are associated with socioemotional development.

The impact of negative affect on attention patterns to threat across the first 2 years of life.

The current study examined the relations between individual differences in attention to emotion faces and temperamental negative affect across the first 2 years of life. Infant studies have noted a normative pattern of preferential attention to salient cues, particularly angry faces. A parallel literature suggests that elevated attention bias to threat is associated with anxiety, particularly if coupled with temperamental risk. Examining the emerging relations between attention to threat and temperamental negative affect may help distinguish normative from at-risk patterns of attention. Infants (N = 145) ages 4 to 24 months (M = 12.93 months, SD = 5.57) completed an eye-tracking task modeled on the attention bias “dot-probe” task used with older children and adults. With age, infants spent greater time attending to emotion faces, particularly threat faces. All infants displayed slower latencies to fixate to incongruent versus congruent probes. Neither relation was moderated by temperament. Trial-by-trial analyses found that dwell time to the face was associated with latency to orient to subsequent probes, moderated by the infant’s age and temperament. In young infants low in negative affect longer processing of angry faces was associated with faster subsequent fixation to probes; young infants high in negative affect displayed the opposite pattern at trend. Findings suggest that although age was directly associated with an emerging bias to threat, the impact of processing threat on subsequent orienting was associated with age and temperament. Early patterns of attention may shape how children respond to their environments, potentially via attention’s gate-keeping role in framing a child’s social world for processing.

Age-related changes in the dynamics of fear-related regulation in early childhood

Self-regulation is a dynamic process wherein executive processes (EP) delay, minimize or desist prepotent responses (PR) that arise in situations that threaten well-being. It is generally assumed that, over the course of early childhood, children expand and more effectively deploy their repertoire of EP-related strategies to regulate PR. However, longitudinal tests of these assumptions are scarce in part because self-regulation has been mostly studied as a static construct. This study engages dynamic systems modeling to examine developmental changes in self-regulation between ages 2 and 5 years. Second-by-second time-series data derived from behavioral observations of 112 children (63 boys) faced with novel laboratory-based situations designed to elicit wariness, hesitation, and fear were modeled using differential equation models designed to capture age-related changes in the intrinsic dynamics and bidirectional coupling of PR (fear/wariness) and EP (strategy use). Results revealed that dynamic models allow for the conceptualization and measurement of fear regulation as intrinsic processes as well as direct and indirect coupling between PR and EP. Several patterns of age-related changes were in line with developmental theory suggesting that PR weakened and was regulated more quickly and efficiently by EP at age 5 than at age 2. However, most findings were in the intrinsic dynamics and moderating influences between PR and EP rather than direct influences. The findings illustrate the precision with which specific aspects of self-regulation can be articulated using dynamic systems models, and how such models can be used to describe the development of self-regulation in nuanced and theoretically meaningful ways.

Audiovisual materials are effective for enhancing the correction of articulation disorders in children with cleft palate

INTRODUCTION Children with cleft palate frequently show speech disorders known as compensatory articulation. Compensatory articulation requires a prolonged period of speech intervention that should include reinforcement at home. However, frequently relatives do not know how to work with their children at home. OBJECTIVE To study whether the use of audiovisual materials especially designed for complementing speech pathology treatment in children with compensatory articulation can be effective for stimulating articulation practice at home and consequently enhancing speech normalization in children with cleft palate. MATERIALS AND METHODS Eighty-two patients with compensatory articulation were studied. Patients were randomly divided into two groups. Both groups received speech pathology treatment aimed to correct articulation placement. In addition, patients from the active group received a set of audiovisual materials to be used at home. Parents were instructed about strategies and ideas about how to use the materials with their children. Severity of compensatory articulation was compared at the onset and at the end of the speech intervention. RESULTS After the speech therapy period, the group of patients using audiovisual materials at home demonstrated significantly greater improvement in articulation, as compared with the patients receiving speech pathology treatment on - site without audiovisual supporting materials. CONCLUSION The results of this study suggest that audiovisual materials especially designed for practicing adequate articulation placement at home can be effective for reinforcing and enhancing speech pathology treatment of patients with cleft palate and compensatory articulation.