Santosh Kamble

Ultrasound promoted efficient and green synthesis of β-amino carbonyl compounds in aqueous hydrotropic medium.

Ultrasound promoted synthesis of β-amino carbonyl compounds in aqueous hydrotropic medium at ambient temperature is reported. The remarkable features of the new procedure are shorter reaction time, excellent yields in aqueous medium, cleaner reaction profile and simple experimental and work-up procedure.

Silica Tethered Pd–DABCO Complex: An Efficient and Reusable Catalyst for Suzuki–Miyaura Reaction

A palladium-based catalyst supported on DABCO-functionalized silica was successfully prepared by a facile procedure. The prepared heterogeneous catalyst showed a high activity for the Suzuki–Miyaura reaction of aryl bromides, affording excellent yield in all the cases investigated. Interestingly, the catalyst could be quantitatively recovered from the reaction mixture and recycled for five times without any significant loss in activity. Furthermore, this protocol could be extended to the palladium catalyzed synthesis of annulated pyrazines.Graphical Abstract

Hydrotrope Induced Catalysis in Water: A Clean and Green Approach for the Synthesis of Medicinally Relevant Bis(indolyl)methanes and 2-Aryl Benzimidazoles

Abstract An efficient synthesis of medicinally relevant bis(indolyl)methanes and 2-aryl benzimidazoles has been achieved in an aqueous hydrotropic solution at ambient temperature. Substantial enhancements in the rates of the reactions along with easy recovery of the products were noted. Additionally, the aqueous hydrotropic solution could be reused for several cycles with modest change in yields of products. GRAPHICAL ABSTRACT

Palladium nanoparticles supported on a titanium dioxide cellulose composite (PdNPs@TiO2–Cell) for ligand-free carbon–carbon cross coupling reactions

Well-dispersed non-spherical PdNPs with a diameter of 39–45 nm supported on a TiO2–cellulose composite (PdNPs@TiO2–Cell) can be synthesized by a simple and clean route. The catalyst was well characterized by XRD, FE-SEM, EDS, and TEM techniques. The PdNPs have good dispersity on the TiO2–Cell support. This results in excellent catalytic activities for the synthesis of biphenyls, acrylates, acetylenes and prochiral ketones using low Pd loading (1 mol%) at comparatively low temperature. The effects of the nature and amount of bases, nature of solvents, amount of catalyst and the reaction temperature on the activity of PdNPs@TiO2–Cell were thoroughly investigated. The catalyst showed at least four times reusability without decrease in catalytic activity.

Hydrotrope induced synthesis of 1,8-dioxo-octahydroxanthenes in aqueous medium

Abstract Hydrotrope induced synthesis of 1,8-dioxo-octahydroxanthenes from aromatic aldehydes and dimedone/1,3-cyclohexadione in aqueous medium is reported. The remarkable features of the new procedure are high conversions, shorter reaction times, cleaner reaction profiles, and simple experimental and work-up procedures.

Hydrotrope: green and rapid approach for the catalyst-free synthesis of pyrazole derivatives

An efficient synthesis of pyrazole derivatives by condensation of 1,3-diketone and hydrazines/hydrazides has been achieved in aqueous hydrotropic solution under catalyst-free conditions within a very short time. The present protocol is beneficial as it includes mild reaction conditions, shorter reaction times, use of universal solvent water, which avoids volatile organic solvents, high yields of products, and being environmentally friendly.Graphical Abstract