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Dive into the research topics where Sara M. Mostafa is active.

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Featured researches published by Sara M. Mostafa.


Chemical Papers | 2012

Formation of dioxospiroindene[1,3]thiazine and thioxoindeno[2,1- d ]imidazolone derivatives from alkenylidene-hydrazinecarbothioamides

Alaa A. Hassan; Ahmed M. Nour El-Din; Fathy F. Abdel-Latif; Sara M. Mostafa; Stefan Bräse

The reaction of (substituted) alkenylidene-hydrazinecarbothioamides with 2-(1,3-dioxo-2,3-dihydro-1H-inden-2-ylidene)propanedinitrile led to the formation of 1,3-dioxospiroindene[1,3]-thiazine and thioxoindeno[2,1-d]imidazolone derivatives in modest yields. In addition, 1,3-dihydroxyindan-2-ylidenepropanedinitrile was found. Explanations of these conversions involving nucleophilic reactions and condensations are presented.


Journal of Chemical Research-s | 2010

Synthesis of spiro(indenepyrazole) and indenotriazinone derivatives from 4-substituted thiosemicarbazides and (1,3-dioxo-2,3-dihydro-1 H -inden-2-ylidene)propanedinitrile

Alaa A. Hassan; Ahmed M. Nour; Fathy F. Abdel Latif; Sara M. Mostafa; Stefan Bräse

In a multistep reaction, N-substituted-5′-amino-4′-cyano-1,3-dioxo-1,3-dihydro-spiro[indene-2,3′-pyrazole]-2′(1H) carbothioamides (63–71 %) and 4-substituted-3-thioxo-3H-indeno[1,2-e][1,2,4] triazin-9(4H)-ones (17–26 %) have been formed, from a series of 4-substituted thiosemicarbazides 1a–f with (1,3-dioxo-2,3-dihydro-1H-inden-2-ylidene)propanedinitrile 3 in aerated ethyl acetate. Rationales of these conversions involving the nucleophilic reactions and condensation are presented.


Chemical Papers | 2015

Heterocyclisation of substituted ylidenethiocarbonohydrazides using dimethyl acetylenedicarboxylate

Alaa A. Hassan; Fathy F. Abdel-Latif; Mohamed Abdel Aziz; Sara M. Mostafa; Stefan Bräse; Martin Nieger

A facile and rapid procedure for the synthesis of dimethyl-2-[3-amino-5-(2-methoxy-2-oxoethylidene)-4-oxothiazolidin-2-ylidenehydrazono]succinate, dimethyl {[2-alkylidenehydrazono)-5-(2-methoxy-2-oxoethylidene)-4-oxothiazolidin-3-yl)amino]succinate and methyl (4-amino-5-oxo-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)acetate affording yields of 61–54 %, 22–18 % and 14–11 %, respectively, via a condensation reaction of dimethyl acetylenedicarboxylate (DMAD) with (substituted ylidene)thiocarbonohydrazides. One of the products was conclusively confirmed by single-crystal X-ray analysis. A mechanism for the formation of the products is presented.


Journal of Heterocyclic Chemistry | 2011

Synthesis of novel spiro(indolone-3,2′-[1,3,4]thiadiazol)-2-ones and evaluation of their antidepressant and anticonvulsant activities

Alaa A. Hassan; Fathy F. Abdel-Latif; Ahmed M. Nour El-Din; Mohamed Abdel-Aziz; Sara M. Mostafa; Stefan Bräse


Tetrahedron | 2012

Synthesis of (E)-2,5-disubstituted 1,3,4-thiadiazolyl-2,3-diphenylpropenones from alkenylidene-hydrazinecarbothioamides

Alaa A. Hassan; Fathy F. Abdel-Latif; Ahmed M. Nour El-Din; Sara M. Mostafa; Martin Nieger; Stefan Bräse


Journal of Heterocyclic Chemistry | 2016

Efficient and Facile Synthesis of Substituted Aminothiadiazolylhydrazonoindolin-2-ones

Alaa A. Hassan; Fathy F. Abdel-Latif; Mohamed Abdel-Aziz; Sara M. Mostafa; Stefan Bräse; Martin Nieger


Synlett | 2015

A Novel Method for the Synthesis of Furo-imidazo[3.3.3]propellanes from Thiocarbonohydrazides

Alaa A. Hassan; Shaaban K. Mohamed; Fathy F. Abdel-Latif; Sara M. Mostafa; Mohamed Abdel-Aziz; Joel T. Mague; Mehmet Akkurt


Journal of Heterocyclic Chemistry | 2017

(Substituted Ylidene)Amino-2-Oxo-Indolylidene Thioureas and Bis(2-Oxo-Indolylidene)Urea from (Ylidene)Thiocarbonohydrazides and Isatylidene Malononitrile: (Ylidene)Amino-2-Oxo-Indolylidene Thioureas and Bis(2-Oxo-Indolylidene)Urea from (Ylidene)Thiocarbonohydrazides and Isatylidene Malononitrile

Alaa A. Hassan; Shaaban K. Mohamed; Fathy F. Abdel-Latif; Sara M. Mostafa; Mohamed Abdel-Aziz; Joel T. Mague; Mehmet Akkurt; Stefan Bräse; Martin Nieger


Tetrahedron Letters | 2016

Tetracyanoethylene as a mediator and building block in synthesis of 5-substituted amino-1,3,4-thiadiazolyl-1H-pyrazole derivatives

Alaa A. Hassan; Shaaban K. Mohamed; Fathy F. Abdel-Latif; Sara M. Mostafa; Joel T. Mague; Mehmet Akkurt; Mohamed Abdel-Aziz


Journal of Heterocyclic Chemistry | 2014

Recent Heterocyclic Compounds from (1,3‐Dioxo‐2,3‐dihydro‐1H‐inden‐2‐ylidene)propanedinitrile

Alaa A. Hassan; Sara M. Mostafa

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Stefan Bräse

Karlsruhe Institute of Technology

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Shaaban K. Mohamed

Manchester Metropolitan University

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