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Dive into the research topics where Sarah Shea is active.

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Featured researches published by Sarah Shea.


Pediatrics | 2004

Risperidone in the Treatment of Disruptive Behavioral Symptoms in Children With Autistic and Other Pervasive Developmental Disorders

Sarah Shea; Atilla Turgay; Alan Carroll; Miklos Schulz; Herbert Orlik; Isabel M. Smith; Fiona Dunbar

Objective. To investigate the efficacy and safety of risperidone for the treatment of disruptive behavioral symptoms in children with autism and other pervasive developmental disorders (PDD). Methods. In this 8-week, randomized, double-blind, placebo-controlled trial, risperidone/placebo solution (0.01–0.06 mg/kg/day) was administered to 79 children who were aged 5 to 12 years and had PDD. Behavioral symptoms were assessed using the Aberrant Behavior Checklist (ABC), Nisonger Child Behavior Rating Form, and Clinical Global Impression-Change. Safety assessments included vital signs, electrocardiogram, extrapyramidal symptoms, adverse events, and laboratory tests. Results. Subjects who were taking risperidone (mean dosage: 0.04 mg/kg/day; 1.17 mg/day) experienced a significantly greater mean decrease on the irritability subscale of the ABC (primary endpoint) compared with those who were taking placebo. By study endpoint, risperidone-treated subjects exhibited a 64% improvement over baseline in the irritability score almost double that of placebo-treated subjects (31%). Risperidone-treated subjects also exhibited significantly greater decreases on the other 4 subscales of the ABC; on the conduct problem, insecure/anxious, hyperactive, and overly sensitive subscales of the Nisonger Child Behavior Rating Form (parent version); and on the Visual Analog Scale of the most troublesome symptom. More risperidone-treated subjects (87%) showed global improvement in their condition compared with the placebo group (40%). Somnolence, the most frequently reported adverse event, was noted in 72.5% versus 7.7% of subjects (risperidone vs placebo) and seemed manageable with dose/dose-schedule modification. Risperidone-treated subjects experienced statistically significantly greater increases in weight (2.7 vs 1.0 kg), pulse rate, and systolic blood pressure. Extrapyramidal symptoms scores were comparable between groups. Conclusions. Risperidone was well tolerated and efficacious in treating behavioral symptoms associated with PDD in children.


Journal of Autism and Developmental Disorders | 2011

The role of prenatal, obstetric and neonatal factors in the development of autism.

Linda Dodds; Deshayne B. Fell; Sarah Shea; B. Anthony Armson; Alexander C. Allen; Susan E. Bryson

We conducted a linked database cohort study of infants born between 1990 and 2002 in Nova Scotia, Canada. Diagnoses of autism were identified from administrative databases with relevant diagnostic information to 2005. A factor representing genetic susceptibility was defined as having an affected sibling or a mother with a history of a psychiatric or neurologic condition. Among 129,733 children, there were 924 children with an autism diagnosis. The results suggest that among those with low genetic susceptibility, some maternal and obstetric factors may have an independent role in autism etiology whereas among genetically susceptible children, these factors appear to play a lesser role. The role of pre-pregnancy obesity and excessive weight gain during pregnancy on autism risk require further investigation.


American Journal of Medical Genetics | 1997

Genealogy, natural history, and phenotype of Alstrom syndrome in a large Acadian kindred and three additional families.

Jan D. Marshall; Mark Ludman; Sarah Shea; Sonia R. Salisbury; Steven M. Willi; Robert G. LaRoche; Patsy M. Nishina

We describe a large Acadian kindred including 8 Alstrom Syndrome (AS) patients, with an age range of 4 to 26 at the time of clinical assessment. The affected subjects come from 5 nuclear families within this kindred. The phenotype includes early childhood retinopathy, progressive sensorineural hearing loss, truncal obesity, and acanthosis nigricans. In addition, hyperinsulinemia and hypertriglyceridemia with normal cholesterol levels were observed in most affected individuals tested. Non-insulin dependent diabetes mellitus and growth retardation appear to be age-related manifestations that occur post-adolescence. Younger affected children are not overtly hyperglycemic and are normal or above average height for age. Although the AS patients in kindred 1 presumably carry the same mutation, many manifestations of the disease are variable. For example, of the 8 children in the Acadian kindred, 4 have scoliosis, 2 have had infantile cardiomyopathy, 2 are hypothyroid, 1 has had hepatic dysfunction and is hypertensive, and 4 have developed asthma. Seven subjects described in this kindred exhibit developmental delay. One additional manifestation not described widely in the literature, advanced bone age, was observed in all subjects tested. The clinical data from this large Acadian kindred, together with information obtained from 4 additional AS patients in 3 unrelated kindreds, confirm and extend clinical observations previously described. In addition, the Acadian kindred with multiple affected individuals, probably arising from a common founder, should allow for identification of the chromosomal localization of a gene causing AS.


Journal of Child Neurology | 1997

Treatment of Children With Williams Syndrome With Methylphenidate

Harry N. Bawden; G. Wayne MacDonald; Sarah Shea

Children with Williams syndrome frequently present with symptoms of attention deficit hyperactivity disorder (ADHD), but there is little information that stimulant medication is useful in this population. A series of double-blind, placebo-controlled case studies was used to evaluate the cognitive and behavioral effects of methylphenidate on four children with Williams syndrome. Teachers and mothers completed behavioral rating scales and cognitive tests of attention, learning and memory, and academic productivity and accuracy in mathematics in each medication condition. Two of the children responded favorably in terms of decreased impulsivity, decreased irritability, and lower activity level as well as improved ability to pay attention. Methylphenidate is a useful adjunct in the treatment of some children with Williams syndrome. (J Child Neurol 1997;12:248—252).


Pediatric Nephrology | 2002

Neuropsychological outcome in children with acquired or congenital renal disease.

John F. S. Crocker; Philip D. Acott; James E. Carter; David S. Lirenman; G. Wayne MacDonald; Mona Mcallister; Mary Catherine Mcdonnell; Sarah Shea; Harry N. Bawden

Abstract. The neuropsychological abilities of children with congenital (n=13) or acquired (n=11) end-stage renal disease (ESRD) were compared. Patients were being treated with or being prepared for dialysis and were awaiting transplantation. None of the children had an identifiable syndrome with associated central nervous system (CNS) dysfunction or had exposure to drugs with known CNS toxicity. There were no group differences in intelligence, academic achievement, behavior, or immediate memory. Children with congenital ESRD had poorer fine motor coordination and more difficulty on tests of verbal and nonverbal long-term memory than children with acquired ESRD. However, the neuropsychological outcome for congenital ESRD is more favorable than previously described. Psychological and education treatment recommendations should be considered.


Canadian Medical Association Journal | 2010

An intercultural and semi-confessional reflection on blood donation

Sarah Shea; Sarah M. Giles

As health care workers, we, the authors, identified here as Younger Sarah and Older Sarah, know how important safe blood products are, so we donate here in Canada. Recently Younger Sarah went to donate in Australia. (Sarah was in Australia and went to give blood. She did not actually go to Australia


Pediatric Research | 1998

Neuropsychological and Behavioural Outcomes in Children with Acquired and Congenital Renal Disease 1795

John F. S. Crocker; Sarah Shea; Mary Catharine McDonnell; James E. Carter; Philip D. Acott; Wayne MacDonald; Mona Mcallister; David S. Lirenman; Harry N. Bawden

Neuropsychological and Behavioural Outcomes in Children with Acquired and Congenital Renal Disease 1795


JAMA Internal Medicine | 2005

New Alström Syndrome Phenotypes Based on the Evaluation of 182 Cases

Jan D. Marshall; Roderick T. Bronson; Gayle B. Collin; Anne D. Nordstrom; Pietro Maffei; Richard B Paisey; Catherine Carey; Seamus Macdermott; Isabelle Russell-Eggitt; Sarah Shea; Judy Davis; Sebastian Beck; Gocha Shatirishvili; Cristina Maria Mihai; Maria Hoeltzenbein; Giovanni Battista Pozzan; Ian Hopkinson; Nicola Sicolo; Juergen K Naggert; Patsy M. Nishina


Seminars in Pediatric Neurology | 2006

Mental Retardation in Children Ages 6 to 16

Sarah Shea


Canadian Family Physician | 2018

Primary care of adults with intellectual and developmental disabilities: 2018 Canadian consensus guidelines

William F. Sullivan; Heidi Diepstra; John Heng; Shara Ally; Elspeth Bradley; Ian Casson; Brian Hennen; Maureen Kelly; Marika Korossy; Karen McNeil; Dara Abells; Khush Amaria; Kerry Boyd; Meg Gemmill; Elizabeth Grier; Natalie Kennie-Kaulbach; Mackenzie Ketchell; Jessica Ladouceur; Amanda Lepp; Yona Lunsky; Shirley McMillan; Ullanda Niel; Samantha Sacks; Sarah Shea; Katherine Stringer; Kyle Sue; Sandra Witherbee

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David S. Lirenman

University of British Columbia

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