Sarika Pandey

Association of Serum CRP level with Lung Cancer and Healthy Control of North Indian Population

BackgroundLung cancer is the major cause of cancer-related mortality worldwide. Chronic inflammation of the airway plays an important role in the alternations of bronchial epithelium and lung microenvironment, therefore provoking the pulmonary carcinogenesis and progression of lung cancer. The results may suggest that high inflammation level can be associated with the higher risk of lung cancer. CRP is an acute-phase protein produced in the liver in response to elevated cytokine levels after an inflammatory stimulus. C-reactive protein (CRP) a systemic marker of chronic inflammation is associated with increased lung cancer risk. Material and MethodologyThis case-control study was conducted on 40 lung cancer patients and 30 healthy controls. CRP level was measured in serum by ELISA kits. ResultsElevated serum CRP level was found in lung cancer patients as comparison to healthy controls. This study shows significant association between the serum CRP level of lung cancer patients and healthy controls (p<0.0001) and also showed significant association between smoker, ex-smoker and non-smokers lung cancer patients as well as in healthy controls (p<0.0001). ConclusionHigher CRP levels were found in lung cancer patients as compared to healthy controls. The higher CRP level was also observed in Smoker, Ex-smoker as compared to non-smoker in lung cancer patients and healthy control. Key-wordsLung Cancer, CRP, Inflammatory Stimulus, Cardiovascular disease, Biomarker INTRODUCTION Lung cancer is the major cause of cancer-related mortality in both men and women worldwide [1] . Chronic inflammation in airway plays an important role in the alternations of bronchial epithelium and lung microenvironment provoking the pulmonary carcinogenesis and progression of lung cancer. The results may suggest that high inflammation level can be associated with the higher risk of lung cancer. It is known that pro-inflammatory cytokines such as interleukin 1, interleukin 2, tumor necrosis factor alpha and tumor growth factor are able to stimulate the production of C-reactive protein (CRP) as well as influence survival, growth, mutation, proliferation, differentiation, and migration of tumor cells [2] . C-reactive protein (CRP) a Access this article online Quick Response Code Website:

Study on Association of BMI with Lung Cancer in North Indian Population

BackgroundLung cancer is one of the most prevalent types of cancer in India. It is considered as the most commonly diagnosed cancer and constitutes the leading cause of cancer-related mortality. The majority of lung cancer is due to smoking. Tobacco use has been reported to be one of the main causes of lung cancer. It has been observed in previous studies that excess body weight and obesity are protective factors against lung cancer in current and former smokers. MethodsThe present study recruited 235 lung cancer patients. BMI was categorized as underweight (BMI <18.5 kg/m), normal weight (BMI 18.5 to <25kg/m), overweight (BMI 25 to <30 kg/m) and obese (BMI≥30 kg/m). The study was conducted to establish the association of BMI with gender, smoking status, and histological subtypes of lung cancer. ResultsOut of 235 patients enrolled, 55.32% were underweight, 40.43% were normal weight, 3.4% of patients were classified as overweight and 0.85% was obese. This study showed a significant association of BMI with smoking status (p<0.0057), while the non-significant association with gender (p=0.75) and histological subtypes (p=0.74). ConclusionWe were concluded that significant association was found between BMI and smoking status, while non significant association was observed between BMI and gender as well as BMI and histological subtypes of lung cancer patients in the north Indian population in this study. Key-wordsBMI, Histological Subtypes, Lung Cancer, Mortality, Smoking INTRODUCTION Lung cancer is one of the most prevalent types of cancer in India and constitutes the leading cause of cancer related mortality worldwide . Lung cancer is defined as the uncontrolled cell growth of lung tissues which may lead to metastasis, invasion of adjacent tissue and infiltration beyond the lungs . The majority of lung cancer cases are due to Tobacco smoking and other environmental pollutants have been recognized as risk factors for cancer. The average five-year survival rate after diagnosis is low . It is essential to emphasize the importance of Lung Cancer prevention, and knowledge of modifiable risk factors such as environmental exposures, tobacco smoking and air pollution is prevalent among good quality epidemiological studies that explain the majority of Lung Cancer incidence . The complex interplay of etiological and psychophysical factors is believed to modify the effect of respiratory carcinogens on lung cancer initiation and prognosis . Access this article online Quick Response Code Website:

Role of jalaneti and pranayama in allergic rhinitis with asthma

Allergic respiratory conditions are a major public health challenge worldwide. Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation. It is defined by the history of respiratory symptoms such as wheeze, shortness of breath, chest tightness, and cough that vary over time and in intensity, together with variable expiratory airflow limitation. Asthma is one of the most common chronic diseases worldwide, with an estimated 300 million affected individuals. It is also an associated disease with allergic rhinitis (AR). AR is characterized by nasal congestion, rhinorrhea, sneezing, itching of the nose, and/or postnasal discharge. It is also closely related to asthma and 10%–40% of people with rhinitis have concomitant asthma Researches in this field are very limited; therefore, this review article will be helpful in updating the knowledge about disease and drugs that can help in satisfying the attending people. Yoga is one of the complementary medicines which are helpful in relaxing the muscles, releasing anxiety, improving blood circulation, respiration, etc. Yoga uses a holistic approach to promote positive health for centuries. A regular practice of jalaneti and pranayama provides the relaxation and sound sleep and works as healing therapy for AR and asthma