Šárka Rýglová
Academy of Sciences of the Czech Republic
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European Journal of Pharmaceutical Sciences | 2017
Tomáš Suchý; Monika Šupová; Eva Klapkova; Václava Adámková; Jan Závora; Margit Žaloudková; Šárka Rýglová; Rastislav Ballay; František Denk; Marek Pokorný; Pavla Sauerová; Marie Kalbacova; Lukáš Horný; Jan Veselý; Tereza Voňavková; Richard Průša
&NA; The aim of this study was to develop an osteo‐inductive resorbable layer allowing the controlled elution of antibiotics to be used as a bone/implant bioactive interface particularly in the case of prosthetic joint infections, or as a preventative procedure with respect to primary joint replacement at a potentially infected site. An evaluation was performed of the vancomycin release kinetics, antimicrobial efficiency and cytocompatibility of collagen/hydroxyapatite layers containing vancomycin prepared employing different hydroxyapatite concentrations. Collagen layers with various levels of porosity and structure were prepared using three different methods: by means of the lyophilisation and electrospinning of dispersions with 0, 5 and 15 wt% of hydroxyapatite and 10 wt% of vancomycin, and by means of the electrospinning of dispersions with 0, 5 and 15 wt% of hydroxyapatite followed by impregnation with 10 wt% of vancomycin. The maximum concentration of the released active form of vancomycin characterised by means of HPLC was achieved via the vancomycin impregnation of the electrospun layers, whereas the lowest concentration was determined for those layers electrospun directly from a collagen solution containing vancomycin. Agar diffusion testing revealed that the electrospun impregnated layers exhibited the highest level of activity. It was determined that modification using hydroxyapatite exerts no strong effect on vancomycin evolution. All the tested samples exhibited sufficient cytocompatibility with no indication of cytotoxic effects using human osteoblastic cells in direct contact with the layers or in 24‐hour infusions thereof. The results herein suggest that nano‐structured collagen‐hydroxyapatite layers impregnated with vancomycin following cross‐linking provide suitable candidates for use as local drug delivery carriers. Graphical abstract Figure. No caption available.
Computer Methods in Biomechanics and Biomedical Engineering | 2012
Tomáš Suchý; Šárka Rýglová; Zbyněk Sucharda; Karel Balík; Josef Sepitka; Jaroslav Lukes
T. Suchý*, Š. Rýglová, Z. Sucharda, K. Balı́k, J. Šepitka and J. Lukeš Department of Composite and CarbonMaterials, Institute of Rock Structure and Mechanics, Academy of Sciences of the Czech Republic, v.v.i, V Holešovickách 41, Prague 8, Czech Republic; Department of Mechanics, Biomechanics and Mechatronics, Faculty of Mechanical Engineering, Czech Technical University in Prague, Technická 4, 166 07 Prague 6, Czech Republic
Ceramics International | 2014
Martin Černý; Martina Halasová; Jana Schwaigstillová; Zdeneˇk Chlup; Zbyneˇk Sucharda; Petr Glogar; Jaroslava Svítilová; Adam Strachota; Šárka Rýglová
Biomedical Materials | 2015
Tomáš Suchý; Monika Šupová; Pavla Sauerová; Martina Verdanova; Zbyněk Sucharda; Šárka Rýglová; Margit Žaloudková; Radek Sedláček; Marie Kalbacova
Ceramics International | 2015
Martin Černý; Zdeněk Chlup; Adam Strachota; Martina Halasová; Šárka Rýglová; Jana Schweigstillová; Jaroslava Svítilová; Martina Havelcová
Journal of Pharmaceutical Sciences | 2016
Tomáš Suchý; Monika Šupová; Eva Klapkova; Lukáš Horný; Šárka Rýglová; Margit Žaloudková; Martin Braun; Zbyněk Sucharda; Rastislav Ballay; Jan Veselý; Hynek Chlup; František Denk
Journal of The European Ceramic Society | 2015
Martin Černý; Zdeněk Chlup; Adam Strachota; Jaroslava Svítilová; Jana Schweigstillová; Martina Halasová; Šárka Rýglová
Science of Advanced Materials | 2013
Tomáš Suchý; Šárka Rýglová; Karel Balík; Karel Smetana; Monika Šupová; Zbyněk Sucharda; Elena Filova; Jana Havlikova; Lucie Bacakova; Gražyna Simha Martynková
Macromolecular Materials and Engineering | 2017
Šárka Rýglová; Martin Braun; Tomáš Suchý
Journal of Bone and Joint Surgery-british Volume | 2015
Rastislav Ballay; Landor I; Tomáš Suchý; Monika Šupová; Eva Klapkova; Lukáš Horný; Šárka Rýglová; M. Zaloudková; Martin Braun; Zbyněk Sucharda