Satoru Mihara
University of California, Davis
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Publication
Featured researches published by Satoru Mihara.
Allergy, Asthma & Clinical Immunology | 2015
Satoru Mihara; Takayuki Shibamoto
TRPA1 has been proposed to be associated with diverse sensory allergic reactions, including thermal (cold) nociception, hearing and allergic inflammatory conditions. Some naturally occurring compounds are known to activate TRPA1 by forming a Michael addition product with a cysteine residue of TRPA1 through covalent protein modification and, in consequence, to cause allergic reactions. The anti-allergic property of TRPA1 agonists may be due to the activation and subsequent desensitization of TRPA1 expressed in sensory neurons. In this review, naturally occurring TRPA1 antagonists, such as camphor, 1,8-cineole, menthol, borneol, fenchyl alcohol and 2-methylisoborneol, and TRPA1 agonists, including thymol, carvacrol, 1’S-1’- acetoxychavicol acetate, cinnamaldehyde, α-n-hexyl cinnamic aldehyde and thymoquinone as well as isothiocyanates and sulfides are discussed.
Journal of Magnetic Resonance | 1980
Satoru Mihara; Takayuki Shibamoto
Abstract The configuration and conformation of N-nitroso-2-methylthiazolidine (1) were assigned from analysis of NMR spectra. The lanthanide-induced shifts (LIS) for 1 could reasonably be explained by assuming coordination of tris(dipivalomethanato)europium(III) [Eu(DPM)3] to the oxygen lone pair of the nitroso group. As a result of the stereospecific association (CT comples) between 1 and benzene, the C4H protons experienced a greater upfield shift than the C2H protons for the Z isomer and vice versa for the E isomer when the solvent was changed from aliphatic to aromatic. Both the coordination of Eu(DPM)3 to the oxygen lone pair of the nitroso group and the formation of the CT complex between 1 and benzene were hindered by the methyl group. The Z/E ratios were increased in polar solvents. The barrier to rotation about the NN bond, which was calculated from the temperature dependence of the NMR spectra of 1, was 20 kcal/mol.
Journal of Agricultural and Food Chemistry | 1990
Satoru Mihara; Satoru Bando; Kimihiro Harada; Nobuko Ishizuka
This work describes a new stirring continuous-extraction system equipped with a fluororesin in a water/organic solvent separation chamber to make the method effective and simple. Recovery of the pure compounds and the losses associated with this method were quantitatively investigated on experiments with model systems. This method has been applied to the separation of flavors from wine
Journal of Agricultural and Food Chemistry | 1980
Satoru Mihara; Takayuki Shibamoto
Journal of Agricultural and Food Chemistry | 1988
Satoru Mihara; Hideki Masuda
Journal of Agricultural and Food Chemistry | 1989
Osamu Nishimura; Kenji Yamaguchi; Satoru Mihara; Takayuki Shibamoto
Journal of Agricultural and Food Chemistry | 1988
Hideki Masuda; Satoru Mihara
Agricultural and biological chemistry | 1989
Shuichi Nakamura; Osamu Nishimura; Hideki Masuda; Satoru Mihara
Journal of Agricultural and Food Chemistry | 1981
Takayuki Shibamoto; Osamu Nishimura; Satoru Mihara
Journal of Agricultural and Food Chemistry | 1990
Osamu Nishimura; Satoru Mihara