Satoru Osaki
Okayama University
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Featured researches published by Satoru Osaki.
Asaio Journal | 2007
Shinya Ugaki; Kozo Ishino; Satoru Osaki; Yasuhiro Kotani; Osami Honjo; Hideo Hoshi; Naoyuki Yokoyama; Katsuhiro Ohuchi; Setsuo Takatani; Shunji Sano
We have developed a miniaturized semiclosed cardiopulmonary bypass (CPB) circuit incorporating a centrifugal blood pump (TinyPump) with a volume of 5 ml. The current study was undertaken to evaluate the hemolytic performance of the TinyPump in comparison with the BioPump and to investigate the impact of different CPB circuit volumes on hemodilution, coagulation, and the inflammatory response. Twelve 1-week-old piglets (3.4 ± 0.2 kg) were used. The circuit comprised a centrifugal pump, a membrane oxygenator, and a cardiotomy reservoir. Cardiopulmonary bypass was conducted with mild hypothermia at 150 ml/kg/min for 3 hours. Transfusion was not performed. Priming volume was 68 ml for the circuit with the TinyPump and 111 ml for the circuit with the BioPump. Although the TinyPump required higher speed, plasma free hemoglobin levels after CPB were not different between the groups. After CPB, the TinyPump group had a significantly higher hematocrit (27% ± 3% vs. 23% ± 3%) and lower platelet reduction rate, lower thrombin-antithrombin complex levels, and lower interleukin-6 levels. Better lung compliance with less water content was observed in the TinyPump group. The TinyPump maintained CPB with acceptable hemolysis and lower inflammatory responses. This miniaturized CPB circuit may make transfusion-free open heart surgery feasible in neonates and would help to prevent postoperative organ dysfunction.
Asaio Journal | 2006
Yasuhiro Kotani; Osami Honjo; Kozo Ishino; Satoru Osaki; Yosuke Kuroko; Takuya Kawabata; Shinya Ugaki; Ko Yoshizumi; Shingo Kasahara; Masaaki Kawada; Shunji Sano
Single-ventricle palliation without the use of cardiopulmonary bypass carries advantages that reduce systemic edema and inflammatory responses; however, simple clamping of the superior vena cava (SVC) without a temporary shunt leads to increase in cerebral venous pressure and subsequent decrease in cerebral blood flow during bidirectional cavopulmonary shunt (BCPS). We report our experience of BCPS, using a centrifugal pump–assisted temporary shunt. The criteria included an unrestrictive interatrial communication, the absence of atrioventricular valve regurgitation, and the existence of an antegrade pulmonary blood flow. From August 2000, 14 children with single-ventricle physiology met the criteria. The mean age was 1.0 ± 0.9 years, and the mean weight was 8.4 ± 2.6 kg. A temporary shunt was established between the SVC and the right atrium with right-angle cannulae, which were connected to a centrifugal pump to accelerate the blood flow from the SVC to the right atrium. All patients tolerated the procedure. Mean central venous pressure was 17 ± 4 mm Hg, and transcutaneous oxygen saturation was maintained at 77 ± 8% during anastomosis. No patients required blood transfusion. There were no postoperative neurological complications. The centrifugal pump–assisted temporary shunt offered safer and more effective circulatory support than other shunt systems, with excellent venous drainage in pediatric patients undergoing BCPS.
The Annals of Thoracic Surgery | 2006
Satoru Osaki; Kozo Ishino; Yasuhiro Kotani; Osami Honjo; Takanori Suezawa; Kazushige Kanki; Shunji Sano
The Journal of Thoracic and Cardiovascular Surgery | 2007
Yasuhiro Kotani; Kozo Ishino; Satoru Osaki; Osami Honjo; Takanori Suezawa; Kazushige Kanki; Chikao Yutani; Shunji Sano
Artificial Organs | 2007
Katsuhiro Ohuchi; Hideo Hoshi; Kazuhiko Ishihara; Masaharu Yoshikawa; Shinya Ugaki; Kozo Ishino; Satoru Osaki; Yasuhiro Kotani; Shunji Sano; Setsuo Takatani
Asaio Journal | 2007
Yasuhiro Kotani; Osami Honjo; Mahito Nakakura; Shinya Ugaki; Takuya Kawabata; Yosuke Kuroko; Satoru Osaki; Ko Yoshizumi; Shingo Kasahara; Kozo Ishino; Shunji Sano
Circulation | 2008
Yasuhiro Kotani; Osami Honjo; Satoru Osaki; Takuya Kawabata; Shinya Ugaki; Yasuhiro Fujii; Ko Yoshizumi; Shingo Kasahara; Kozo Ishino; Shunji Sano
Circulation | 2007
Osami Honjo; Yasuhiro Kotani; Teiji Akagi; Satoru Osaki; Masaaki Kawada; Kozo Ishino; Shunji Sano
The Annals of Thoracic Surgery | 2006
Osami Honjo; Yasuhiro Kotani; Satoru Osaki; Yasufumi Fujita; Takanori Suezawa; Atsushi Tateishi; Kozo Ishino; Masaaki Kawada; Teiji Akagi; Shunji Sano
Circulation | 2010
Osami Honjo; Satoru Osaki; Yasuhiro Kotani; Teiji Akagi; Shunji Sano