Satoru Yamagami | Researchain

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Cell Biology International Reports | 1987

Induction of tumouricidal macrophages by MTP-PE: its enhancement by a factor produced spontaneously by tumour cells.

Satoru Yamagami; Anne F. Brownbill; Gebhard Schumann

Tumouricidal activity of rat alveolar macrophages is induced by MTP-PE in vitro. This tumouricidal activity is enhanced by a factor (tumour cell derived immunostimulating factor, TCIF) contained in tumour cell culture supernatants. TCIF is not species specific, since culture supernatants of rat MADB-200 as well as mouse B16 or Meth A tumour cells showed similar effects on rat alveolar macrophages. TCIF is not produced in cultures of normal cells, e.g. rat embryo cells. TCIF produced by MADB-200 tumour cells is relatively heat-stable and dialyzable. It is destroyed by treatment at pH 2 for 24 hrs. These results suggest that TCIF can participate in macrophage activation and could be of potential therapeutic value.

Drug Metabolism and Pharmacokinetics | 1993

Studies on the Disposition of Fadrozole Hydrochloride (CGS 16949A) (I): Absorption, Distribution, Metabolism and Excretion after a Single Oral Administration to Rats.

Satoru Yamagami; Eiko Kawasaki; Asao Egawa; Yoshio Esumi; Katsuyuki Hori; Msao Ishizaki; Takako Honda; Hiromi Moriki

Drug Metabolism and Pharmacokinetics | 1991

Studies on the Metabolic Fate of Felodipine. (II): Absorption, Distribution, Metabolism and Excretion after Repeated Oral Administration to Rats.

Kazuo Uno; Satoru Yamagami; Syoryo Hayashi; Shigeru Tabata; Yoshio Esumi; Matsuo Takaichi; Yoshitaka Jin; Hisako Ishikawa; Sadao Tsuji

Drug Metabolism and Pharmacokinetics | 1992

Studies on the Metabolic Fate of Felodipine. (IV). Identification of New Metabolites of Felodipine in Rat.

Kazuo Uno; Satoru Yamagami; Shigeru Tabata; Shuji Kondo; Yoshio Esumi; Matsuo Takaichi; Yoshitaka Jin; Hisako Ishikawa; Sadao Tsuri

Drug Metabolism and Pharmacokinetics | 1992

Studies on the metabolic fate of Benazepril hydrochloride in rats (II) : Plasma level profile, distribution, metabolism and excretion after repeated oral administration.

Kazuo Uno; Satoru Yamagami; Hiroka Shigetoh; Yoshio Esumi; Matsuo Takaichi; Atsushi Takao; Yuuji Okada; Hiroshi Shimizu; Hideaki Seki

Drug Metabolism and Pharmacokinetics | 1992

Studies on the metabolic fate of Benazepril hydrochloride in rats (III) : Investigation of placental transfer and tranfer into milk

Kazuo Uno; Satoru Yamagami; Hiroka Shigetoh; Yoshio Esumi; Matsuo Takaichi; Atsushi Takao; Hideaki Seki

Drug Metabolism and Pharmacokinetics | 1991

Studies on the Metabolic Fate of Felodipine (I):Absorption, Distribution, Metabolism and Excretion (I):Absorption, Distribution, Metabolism and Excretion after a Single Administration to Rats

Kazuo Uno; Satoru Yamagami; Syoryo Hayashi; Shigeru Tabata; Yoshio Esumi; Matsuo Takaichi; Yoshitaka Jin; Hisako Ishikawa; Sadao Tsuji

Drug Metabolism and Pharmacokinetics | 1991

A pharmacokinetics study of Oxiracetam in rats (I):Plasma levels profile, tissue distribution, metabolism and excretion after single administration

Hiroka Shigetoh; Satoru Yamagami; Kazuo Uno; Noriyasu Takayanagi; Yoshio Esumi; Yoshitaka Jin; Atsushi Takao; Hitoshi Shimizu; Tomoko Kawakami; Naomi Shiramizu

Drug Metabolism and Pharmacokinetics | 1991

Studies on the Metabolic Fate of Felodipine (III):Absorption Site, Protein Binding, Distribution in Blood Cell, and Transfer into Fetus and Milk in Rats

Kazuo Uno; Satoru Yamagami; Syoryo Hayashi; Shigeru Tabata; Yoshio Esumi; Matsuo Takaichi; Yoshitaka Jin; Hisako Ishikawa

Drug Metabolism and Pharmacokinetics | 1991

A pharmacokinetics study on Oxiracetam in rats (III):Feto-placental transfer and its transfer into milk

Hiroka Shigetoh; Satoru Yamagami; Kazuo Uno; Noriyasu Takayanagi; Yoshio Esumi; Yoshitaka Jin; Atsushi Takao; Hitoshi Shimizu; Tomoko Kawakami; Naomi Shiramizu

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