Satoshi Niizuma
Hoffmann-La Roche
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Publication
Featured researches published by Satoshi Niizuma.
Bioorganic & Medicinal Chemistry Letters | 2001
Kenichi Kawasaki; Miyako Masubuchi; Kenji Morikami; Satoshi Sogabe; Tsunehisa Park-front Residence Aoyama; Hirosato Ebiike; Satoshi Niizuma; Michiko Hayase; Toshihiko Fujii; Kiyoaki Sakata; Hidetoshi Shindoh; Yasuhiko Shiratori; Yuko Aoki; Tatsuo Ohtsuka; Nobuo Shimma
Potent and selective Candida albicans N-myristoyltransferase (CaNmt) inhibitors have been identified through optimization of a lead compound 1 discovered by random screening. The inhibitor design is based on the crystal structure of the CaNmt complex with compound (S)-3 and structure-activity relationships (SARs) have been clarified. Modification of the C-4 side chain of 1 has led to the discovery of a potent and selective CaNmt inhibitor 11 (RO-09-4609), which exhibits antifungal activity against C. albicans in vitro.
Archive | 2006
Kazuo Hattori; Satoshi Niizuma; Takehiro Chugai Seiyaku Kabushiki Kaisha Okada; Hiroyuki Eda; Kenji Tatsuno; Miyuki Yoshida
Archive | 2002
Takeshi Murata; Satoshi Niizuma; Nobuo Shimma; Hitomi Suda; Masao Tsukazaki
Archive | 2009
Hiroshi Fukuda; Takeshi Murata; Satoshi Niizuma; Hitomi Suda; Masao Tsukazaki
Archive | 2004
Takeshi Murata; Satoshi Niizuma; Nobuo Shimma; Hitomi Suda; Masao Tsukazaki
Archive | 2004
Hiroshi Fukuda; Takeshi Murata; Satoshi Niizuma; Hitomi Suda; Masao Tsukazaki
Archive | 2016
Takeshi Murata; Sousuke Hara; Satoshi Niizuma; Kihito Hada; Hatsuo Kawada; Masahiro Sakaitani; Hideaki Shimada; Yoshito Nakanishi
Archive | 2017
Hatsuo Kawada; Hideaki Shimada; Hiroshi Tanaka; Kihito Hada; Satoshi Niizuma; Sousuke Hara; Takeshi Murata; Yoshito Nakanishi
Archive | 2014
Toshiyuki Mio; Satoshi Niizuma; Kihito Hada; Takeshi Murata; Hatsuo Kawada; Sousuke Hara; Hideaki Shimada; Hiroshi Tanaka
Peptide science : proceedings of the ... Japanese Peptide Symposium | 2012
Kohji Nagano; Noriyuki Inomata; Takashi Shinkawa; Osamu Kondoh; Kazuo Hattori; Miyako Masubuchi; Satoshi Niizuma; Hidemi Saito; Yoshito Nakanishi; Nobuya Ishii; Yuko Aoki; Masayuki Haramura
