Satoshi Nojima
Dainippon Sumitomo Pharma Co., Ltd.
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Featured researches published by Satoshi Nojima.
Archiv Der Pharmazie | 1998
Yoshiaki Kiso; Satoshi Yamaguchi; Hikaru Matsumoto; Tsutomu Mimoto; Ryohei Kato; Satoshi Nojima; Haruo Takaku; Tominaga Fukazawa; Tooru Kimura; Kenichi Akaji
The development of an effective therapeutic agent for the treatment of AIDS continues to be a challenging problem. Since the discovery that the virally encoded HIV protease is vital for propagation, inhibition of this enzyme has become a major target for AIDS chemotherapy. Consequently, numerous efforts aimed at the development of potent and selective inhibitors have been undertaken[2]. Based on the substrate transition state, we designed and synthesized a novel class of HIV protease inhibitors containing allophenylnorstatine [Apns; (2S,3S)‐3‐amino‐2‐hydroxy‐4‐phenylbutyric acid] with a hydroxymethylcarbonyl (HMC) isostere. Among them, the tripeptide KNI‐272 was a highly selective and superpotent HIV protease inhibitor (Ki=5.5 pM)[3]. KNI‐272 exhibited potent in vitro and in vivo antiviral activities with low cytotoxicity[4]. The NMR, X‐ray crystallography, and molecular modeling studies showed that the HMC group in KNI‐272 interacted excellently with the aspartic acid carboxyl groups of the HIV protease active site[5].
Journal of Medicinal Chemistry | 1999
Tsutomu Mimoto; Ryohei Kato; Haruo Takaku; Satoshi Nojima; Keisuke Terashima; Satoru Misawa; Tominaga Fukazawa; Takamasa Ueno; Hideharu Sato; Makoto Shintani; Yoshiaki Kiso; Hideya Hayashi
Chemical & Pharmaceutical Bulletin | 2000
Tsutomu Mimoto; Naoko Hattori; Haruo Takaku; Sumitsugu Kisanuki; Tominaga Fukazawa; Keisuke Terashima; Ryohei Kato; Satoshi Nojima; Satoru Misawa; Takamasa Ueno; Junya Imai; Hiroshi Enomoto; Shigeki Tanaka; Hiroshi Sakikawa; Makoto Shintani; Hideya Hayashi; Yoshiaki Kiso
Bioorganic & Medicinal Chemistry | 2004
Tsutomu Mimoto; Keisuke Terashima; Satoshi Nojima; Haruo Takaku; Mitsunobu Nakayama; Makoto Shintani; Takashi Yamaoka; Hideya Hayashi
Archive | 2006
Tsutomu Mimoto; Satoshi Nojima; Naoya Kinomura; Yoshiaki Kiso
Bioorganic & Medicinal Chemistry | 2008
Tsutomu Mimoto; Satoshi Nojima; Keisuke Terashima; Haruo Takaku; Makoto Shintani; Hideya Hayashi
Archive | 2011
Megumi Maruyama; Naoya Kinomura; Satoshi Nojima; Masahiro Takamura; Keisuke Kakiguchi; Hiroto Tatamidani
Archive | 1997
Haruo Takaku; Satoshi Nojima; Tsutomu Mimoto; Keisuke Terashima; Yoshiaki Kiso
Archive | 2001
Tsutomu Mimoto; Keisuke Terashima; Haruso Takaku; Shinji Matsumoto; Makoto Shintani; Satoshi Nojima
Peptide chemistry : proceedings of the ... Symposium on Peptide Chemistry | 1996
Satoshi Yamaguchi; Takatoshi Mitoguchi; Shingo Nakata; Tooru Kimura; Kenichi Akaji; Satoshi Nojima; Haruo Takaku; Tsutomu Mimoto; Yoshiaki Kiso