Satoshi Okuno
University of Tokyo
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Featured researches published by Satoshi Okuno.
Carbohydrate Research | 1992
Tamio Sugawara; Kunihiko Irie; Hiroyuki Iwasawa; Takayoshi Yoshikawa; Satoshi Okuno; Hiroshi Watanabe; Takashi Kato; Mitsuru Shibukawa; Yukio Ito
omega-(Methoxycarbonyl)alkyl glycopyranosides of D-mannose having C4, C7, C9, C12, and C15 carbon chains, L-fucose and 2-acetamido-2-deoxy-D-mannose having C7 and C9 carbon chains, D-xylose and 2-acetamido-2-deoxy-L-fucose having a C9 carbon chain, and 9-(methoxycarbonyl)-3,6-dioxanonyl glycopyranosides of D-mannose, 2-acetamido-2-deoxy-D-mannose, and L-fucose were synthesized as intermediates for coupling to human serum albumin in order to examine the effect of chain length and hydrophobicity of the spacer arm on the binding specificity of lectins. 8-(Methoxycarbonyl)octyl glycosides of beta-D-Man-(1----2)-alpha-D-Man, alpha-D-Man-(1----2)-alpha-D-Man, alpha-D-ManNAc-(1----2)-alpha-D-Man, beta-D-GlcNAc-(1----2)-alpha-D-Man, and their 6-O-positional isomers, beta-D-Man-(1----6)-alpha-D-Man, alpha-D-Man-(1----6)-alpha-D-Man, alpha-D-ManNAc-(1----6)-alpha-D-Man, and beta-D-GlcNAc-(1----6)-alpha-D-Man, were also synthesized.
Clinical Cancer Research | 2005
Fumiko Fujita; Masako Koike; Masahide Fujita; Yasuo Sakamoto; Satoshi Okuno; Takayuki Kawaguchi; Shigeru Yano; Toshiro Yano; Satoko Kiuchi; Toshihisa Fujiwara; Shinzoh Kudoh; Masatoshi Kakushima
Purpose: The purpose of the present study was to evaluate the antitumor activity and pharmacokinetic profile of MEN4901/T-0128 in nude mice bearing human tumor xenografts in comparison with irinotecan (CPT-11) and T-2513. Experimental Design: We have determined the antitumor activity of MEN4901/T-0128, CPT-11, and T-2513 in BALB/cA Jcl nude mice bearing human gastric (H-81), colon (H-110), lung (Mqnu-1, H-74), esophageal (H-204), liver (H-181), and pancreatic (H-48) cancer lines, which had been serially transplanted s.c. and maintained in nude mice, and characterized the pharmacokinetic profile of MEN4901/T-0128 in nude mice bearing human gastric carcinoma St-4. Results: MEN4901/T-0128 administered i.v. showed a marked antitumor activity in each of these tumor models, producing tumor shrinkage in the models of H-204 and H-181 carcinomas at its maximum tolerated dose of 80 mg/kg (expressed as T-2513) weekly for 4 weeks (q7d × 4) and tumor-shrinking or marked growth-inhibitory effects in the models of H-81, H-110, Mqnu-1, H-74, and H-48 carcinomas at 1/3 of its maximum tolerated dose (q7d × 4). Pharmacokinetic analysis showed that MEN4901/T-0128 had an extended plasma half-life with sustained tumor levels of T-2513, which may explain the superior activity of MEN4901/T-0128 in vivo. Conclusions: Because the efficacies of some drugs in this human cancer-nude mouse panel correlated well with their clinical outcomes in patients with the same type of cancers, the findings provide direct support that MEN4901/T-0128 is more efficacious than CPT-11 and is an excellent candidate for clinical trials for the treatment of solid tumors.
Biological & Pharmaceutical Bulletin | 1994
Akinori Gonsho; Kunihiko Irie; Hiroshi Susaki; Hiroyuki Iwasawa; Satoshi Okuno; Tamio Sugawara
Biological & Pharmaceutical Bulletin | 2001
Shu-ichi Sugahara; Satoshi Okuno; Toshiro Yano; Hiroshi Hamana; Kazuhiro Inoue
Journal of Pharmacology and Experimental Therapeutics | 1999
Kokichi Suzuki; Hiroshi Susaki; Satoshi Okuno; Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics | 1999
Kokichi Suzuki; Hiroshi Susaki; Satoshi Okuno; Harutami Yamada; Hiroshi Watanabe; Yuichi Sugiyama
Archive | 1994
Hideo Nogusa; Hiroshi Hamana; Toshiro Yano; Masahiro June-Palace Hatsuishi Kajiki; Keiji Yamamoto; Satoshi Okuno; Shuichi Sugawara; Nobukazu Kashima; Kazuhiro Inoue
Archive | 1994
Hideo Nogusa; Hiroshi Hamana; Toshiro Yano; Masahiro Kajiki; Keiji Yamamoto; Satoshi Okuno; Shuichi Sugawara; Nobukazu Kashima; Kazuhiro Inoue
The Journal of Antibiotics | 1978
Katsuo Takeda; Akio Kinumaki; Satoshi Okuno; Tadahiro Matsushita; Yukio Ito
Archive | 1991
Kazuhiro Inoue; Teruomi Ito; Satoshi Okuno; Katsutoshi Aono