Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Satyanarayana Medicherla.
Bioorganic & Medicinal Chemistry | 2003
Partha Neogi; Fredrick J Lakner; Satyanarayana Medicherla; Jin Cheng; Debendranath Dey; Maya Gowri; Bishwajit Nag; Somesh D. Sharma; Lesley B Pickford; Coleman Gross
A number of 2,4-thiazolidinedione derivatives of -phenyl substituted cinnamic acid were synthesized and studied for their PPAR agonist activity. The E-isomer of cinnamic acid, 11, showed moderate PPAR transactivation. The corresponding Z-isomer, 23, and double bond reduced derivative, 15, were found to be much less potent. Although the E-isomer showed a moderate PPAR gamma transactivation, it demonstrated a strong glucose-lowering effect in a genetic rodent model of diabetes. Results of pharmacokinetic, metabolism and permeability studies are consistent with 11 being an active prodrug with an active metabolite, 14, that has similar glucose lowering and PPAR gamma agonist properties.
Archive | 2001
Bishwajit Nag; Debendranath Dey; Satyanarayana Medicherla; Partha Neogi
Archive | 1998
Bishwajit Nag; Satyanarayana Medicherla; Somesh D. Sharma
Archive | 2001
Bishwajit Nag; Debendranath Dey; Satyanarayana Medicherla; Partha Neogi
Archive | 2008
Bishwajit Nag; Debendranath Dey; Satyanarayana Medicherla; Partha Neogi
Archive | 1998
Bishwajit Nag; Satyanarayana Medicherla; Jai P. Chansouria; Anil B. Ray
Archive | 2000
Partha Neogi; Bishwajit Nag; Frederick J. Lakner; Debendranath Dev; Satyanarayana Medicherla
Archive | 2003
Bishwagit Nag; Debendranath Dey; Satyanarayana Medicherla; Partha Neogi
Archive | 2002
Partha Neogi; Bishwajit Nag; Frederick J. Lakner; Debendranath Dev; Satyanarayana Medicherla
Archive | 2001
Partha Neogi; Bishwajit Nag; Satyanarayana Medicherla; Debendranath Dey
