Scott Mcnitt

Ranolazine Shortens Repolarization in Patients with Sustained Inward Sodium Current Due to Type‐3 Long‐QT Syndrome

Introduction: One form of the hereditary long‐QT syndrome, LQT3‐ΔKPQ, is associated with sustained inward sodium current during membrane depolarization. Ranolazine reduces late sodium channel current, and we hypothesized that ranolazine would have beneficial effects on electrical and mechanical cardiac function in LQT3 patients with the SCN5A‐ΔKPQ mutation.

Safety and Efficacy of Flecainide in Subjects with Long QT‐3 Syndrome (ΔKPQ Mutation): A Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial

Background: We conducted a study of chronic therapy with flecainide versus placebo in a small group of LQT‐3 patients with the ΔKPQ deletion to evaluate the safety and efficacy of flecainide in this genetic disorder. In vitro studies have shown that flecainide provides correction of the impaired inactivation associated with the ΔKPQ deletion.

Risk of Mortality for Ventricular Arrhythmia in Ambulatory LVAD Patients

Risk of Mortality for Ventricular Arrhythmia. Background: There are limited data regarding the incidence and prognostic significance of ventricular arrhythmias (VA) in ambulatory continuous flow left ventricular assist device (LVAD) patients.

Predictive Capability of Left Atrial Size Measured by CT, TEE, and TTE for Recurrence of Atrial Fibrillation Following Radiofrequency Catheter Ablation

Background: Recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA) has been well established and is in part related to left atrial (LA) size. The purpose of this study was to assess the predictive capability of LA diameter (LAD) and LA volume (LAV) by echocardiography and computed tomography (CT) to determine success in patients undergoing RFCA of AF.

QRS Fragmentation and the Risk of Sudden Cardiac Death in MADIT II

QRS Fragmentation and the Risk of Sudden Cardiac Death in MADIT II.

Impaired T‐Amplitude Adaptation to Heart Rate Characterizes IKr Inhibition in the Congenital and Acquired Forms of the Long QT Syndrome

Introduction:u2002The QTc interval prolongation is not a perfect surrogate marker of the presence of an increased risk for arrhythmic events. In the search for alternative markers, we investigated the T‐amplitude and QT interval adaptation to heart rate (HR) in patients with the congenital long QT syndrome (LQTS) and individuals with sotalol‐induced QT prolongation.

End‐of‐Life Care in Patients with Implantable Cardioverter Defibrillators: A MADIT‐II Substudy

Implantable cardioverter defibrillator (ICD)‐delivered shocks can cause substantial distress, warranting consideration of ICD deactivation at end of life. This study was designed to describe the patterns of end‐of‐life management in patients with ICDs.

Frequency of Inappropriate Therapy in Patients Implanted with Dual‐ Versus Single‐Chamber ICD Devices in the ICD Arm of MADIT‐CRT

The majority of implantable cardioverter defibrillators (ICDs) are dual‐chamber devices, but studies on the frequency of inappropriate therapy in dual‐ versus single‐chamber devices have shown conflicting results. The aim of this study is to determine whether implantation of dual‐chamber ICD devices decrease the incidence of inappropriate therapy without an unacceptable increase in complications.

Mechanisms of Ventricular Fibrillation Initiation in MADIT II Patients with Implantable Cardioverter Defibrillators

Background: The availability of stored intracardiac electrograms from implantable defibrillators (ICDs) has facilitated the study of the mechanisms of ventricular tachyarrhythmia onset. This study aimed to determine the patterns of initiation of ventricular fibrillation (VF) in Multicenter Automatic Defibrillator Implantation Trial (MADIT) II patients along with associated electrocardiogram (ECG) parameters and clinical characteristics.

Effect of elapsed time from coronary revascularization to implantation of a cardioverter defibrillator on long-term survival in the MADIT-II trial.

Coronary Revascularization and Long‐Term Mortality in MADIT‐II.u2002Introduction: Coronary revascularization (CR) may reduce arrhythmia risk and improve long‐term outcome in patients with left ventricular dysfunction. This study was designed to evaluate the effect of elapsed time from CR on long‐term mortality and arrhythmic risk among patients who receive an implantable cardioverter defibrillator (ICD).