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Dive into the research topics where Sean Duffy is active.

Publication


Featured researches published by Sean Duffy.


British Journal of Obstetrics and Gynaecology | 2005

Female sterilisation: a cohort controlled comparative study of ESSURE versus laparoscopic sterilisation

Sean Duffy; Fiona Marsh; Lynne Rogerson; Heather Hudson; Kevin G. Cooper; Stuart A. Jack; David J. Hunter; Graham Philips

Objective  To compare patient satisfaction, discomfort, procedure time, success rate and adverse events of hysteroscopic (ESSURE, Conceptus Inc, San Carlos, USA) versus laparoscopic sterilisation.


Medical Education | 2007

A systematic review of studies assessing and facilitating attitudes towards professionalism in medicine

Vikram Jha; Hilary Bekker; Sean Duffy; Trudie Roberts

Objectives  An essential aspect of medical education is to facilitate the development and assessment of appropriate attitudes towards professionalism in medicine. This systematic review provides a summary of evidence for measures that have been used to assess these attitudes and their psychometric rigour. It also describes interventions that have been found to be effective in changing such attitudes.


British Journal of Obstetrics and Gynaecology | 2003

The differential expression of oestrogen receptors, progesterone receptors, Bcl‐2 and Ki67 in endometrial polyps

Lydia Taylor; Tracy L. Jackson; Janet G. Reid; Sean Duffy

Objective To obtain a greater understanding of the pathogenesis of endometrial polyps and to gain insight into which factors play a pivotal role in their growth.


American Journal of Reproductive Immunology | 2001

The Carriage of Pro‐Inflammatory Cytokine Gene Polymorphisms in Recurrent Pregnancy Loss

Janet G. Reid; Nigel Simpson; Robert G. Walker; Olga Economidou; Jane Shillito; Sean Duffy; James J. Walker; H.‐C. Gooi

PROBLEM: Recurrent pregnancy loss (RPL) affects 2–4% of couples, and remains largely unexplained. Recent studies have examined the role of cytokines in the maintenance of normal pregnancy, which is linked with an increased expression of Th2 cytokines. Overexpression of Th1 cytokines is associated with RPL. Knowing that functional polymorphisms exist for certain cytokines, it has therefore been suggested that women with RPL may have a genetic predisposition to overexpress Th1 cytokines.
 METHOD OF STUDY: The genes for interleukin‐1 beta (IL‐1β) and tumor necrosis factor alpha (TNF‐α) carry functional gene polymorphisms. In both cases these are biallelic polymorphisms that can be detected by polymerase chain reaction followed by restriction fragment length polymorphism. The aim of this pilot study was to assess whether carriage of the rarer alleles (TNF*2 and IL‐1B*2) could act as independent risk factors in recurrent miscarriage.
 RESULTS: We found an increased incidence in the carriage of TNF*2, more pronounced in those women with two or more miscarriages. Carriage of the IL‐1B*2 either alone or in association with TNF*2 was not associated with recurrent miscarriage.
 CONCLUSION: There may be a role for these cytokine gene polymorphisms in RPL.


British Journal of Obstetrics and Gynaecology | 2002

A comparison of outpatient hysteroscopy with saline infusion hysterosonography

Lynne Rogerson; Jane Bates; Michael Weston; Sean Duffy

Objectives To establish the accuracy of saline infusion hysterosonography in diagnosing uterine pathology when compared with outpatient hysteroscopy.


Medical Education | 2006

Perceptions of professionalism in medicine: a qualitative study

Vikram Jha; Hilary Bekker; Sean Duffy; Trudie Roberts

Purpose  Current guidelines for medical undergraduate education require students to develop appropriate attitudes towards professionalism. As much of the literature defines professionalism in vague terms − altruism, humanism, excellence − few studies have operationalised medical professionalism. This study aims to describe the views and experiences individuals have about medical professionalism to provide a more comprehensive understanding of medical professionalism.


British Journal of Obstetrics and Gynaecology | 1998

Flexible outpatient hysteroscopy without anaesthesia: a safe, successful and well tolerated procedure

Christian Kremer; Sukumar Barik; Sean Duffy

The objective of this study was to assess the feasibility and tolerance of diagnostic outpatient flexible hysteroscopy without anaesthesia. Records from 554 consecutive patients were analysed retrospectively. Success rate, reasons for failure, adverse reactions and level of pain were the main outcome measures. Hysteroscopy was successful in 90.5% of patients and well tolerated in 93.3%; 5.4% experienced moderate to severe pain. Inability to negotiate the cervical canal accounted for 47% of failed procedures and poor view for 42%. These results suggest that flexible outpatient hysteroscopy without anaesthesia is a successful and well tolerated procedure.


British Journal of Obstetrics and Gynaecology | 2006

A randomised controlled trial comparing outpatient versus daycase endometrial polypectomy

Fiona Marsh; Lynne Rogerson; Sean Duffy

Objective  To evaluate outpatient versus daycase endometrial polypectomy by comparing success rate, complications, patient tolerance, pain score, analgesia requirement and recovery.


British Journal of Obstetrics and Gynaecology | 2004

Delivering an effective outpatient service in gynaecology. A randomised controlled trial analysing the cost of outpatient versus daycase hysteroscopy

Fiona Marsh; Christian Kremer; Sean Duffy

Objective  To examine the cost implications of outpatient versus daycase hysteroscopy to the National Health Service, the patient and their employer.


Current Medical Research and Opinion | 2006

Defining the role of aromatase inhibitors in the adjuvant endocrine treatment of early breast cancer

Aman U. Buzdar; Rowan T. Chlebowski; Jack Cuzick; Sean Duffy; John F Forbes; Walter Jonat; Peter M. Ravdin

ABSTRACT Background: Over the past few years, data have been published concerning the relative efficacy and safety profiles of tamoxifen and the aromatase inhibitors (AIs) in the adjuvant therapy setting for women with early hormone receptor-positive breast cancer. Recently, debate has centred around trials which have studied primary tamoxifen and AI therapy, switching and equencing strategies and extended adjuvant therapy. Methods: Here, a group of 24 breast cancer experts review efficacy and safety data from the recent major trials investigating tamoxifen and the third-generation AIs in postmenopausal women, which have challenged the perception of tamoxifen as optimum adjuvant endocrine therapy. Data from the Arimidex, Tamoxifen, Alone or in Combination (ATAC) trial, Breast International Group (BIG) 1‐98 study, National Cancer Institute of Canada MA 17 trial, Intergroup Exemestane Study (IES), Italian Tamoxifen Anastrozole (ITA) trial, Austrian Breast and Colorectal Cancer Study Group (ABCSG) Trial 8 and Arimidex-Nolvadex (ARNO) 95 are considered to provide a rational interpretation of the impact of these data on current practice, and to highlight areas where further investigation is needed. Conclusion: We can be confident that AIs represent superior adjuvant endocrine treatment to tamoxifen in postmenopausal women, either as initial therapy or as an alternative for women who have started adjuvant therapy with tamoxifen. However, there remain issues regarding the best way to use AIs, such as the optimal length of AI treatment and how a sequence of tamoxifen followed by an AI compares with AI monotherapy; these will require further data to resolve.

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Fiona Marsh

St James's University Hospital

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Lynne Rogerson

St James's University Hospital

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Christian Kremer

St James's University Hospital

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Andrew Weeks

University of Liverpool

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Heather Hudson

St James's University Hospital

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Jack Cuzick

Queen Mary University of London

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