Sean Ritchie | Researchain

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Featured researches published by Sean Ritchie.

Bioorganic & Medicinal Chemistry Letters | 2009

Water-soluble prodrugs of an Aurora kinase inhibitor.

Johan D. Oslob; Stacey A. Heumann; Chul H. Yu; Darin Allen; Subramanian Baskaran; Minna Bui; Erlie Delarosa; Amy D. Fung; Ahmad Hashash; Jonathan Hau; Sheryl N. Ivy; Jeffrey W. Jacobs; Willard Lew; Jack Maung; Robert S. McDowell; Sean Ritchie; Michael J. Romanowski; Jeffrey A. Silverman; Wenjin Yang; Min Zhong; Tarra Fuchs-Knotts

Compound 1 (SNS-314) is a potent and selective Aurora kinase inhibitor that is currently in clinical trials in patients with advanced solid tumors. This communication describes the synthesis of prodrug derivatives of 1 with improved aqueous solubility profiles. In particular, phosphonooxymethyl-derived prodrug 2g has significantly enhanced solubility and is converted to the biologically active parent (1) following iv as well as po administration to rodents.

Cancer Chemotherapy and Pharmacology | 2010

SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo

Jennifer P. Arbitrario; Brian J. Belmont; Marc J. Evanchik; W. Michael Flanagan; Raymond V. Fucini; Stig Hansen; Shannon O. Harris; Ahmad Hashash; Ute Hoch; Jennifer N. Hogan; Anthony Howlett; Jeffrey W. Jacobs; Joni W. Lam; Sean Ritchie; Michael J. Romanowski; Jeffrey A. Silverman; David E. Stockett; Juli Teague; Kristin M. Zimmerman; Pietro Taverna

Archive | 2010