Sebahattin Hacıyakupoğlu

Effects of arginine vasopressin and v1 receptor antagonist on cerebral vasospasm secondary to subarachnoid hemorrhage: an experimental study

AIM To examine morphological, radiological and biochemical effects of arginine vasopressin (AV) and V1 receptor antagonist on cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) in rabbits. MATERIAL AND METHODS Forty male New Zealand white rabbits were randomly divided into four groups comprising 10 rabbits each. The groups were; 1) Control group, 2) SAH group, 3) SAH+AV group, 4) SAH+V1 antagonist group. Diameters of the basilar artery in all groups were measured on angiograms. All animals were sacrificed two days following basilar angiography and tissue samples of basilar artery were obtained under microscope immediate after craniectomy for ultrastructural and biochemical examinations. RESULTS The artery diameters were found to be 50% and 50% at the 30th minute in the groups 2 and 3 respectively. In group 3, CVS was 13% more in comparison with the 2nd group. In group 4, vascular constriction was 34.5% at the 30th minute and about 30.9% at the 300th minute. Despite the increase in regional blood flow, AV did not provide morphological change. Histological appearance was related to vascular stenosis due to CVS. Histological outcome was the best in group 4 because of less CVS. CONCLUSION Arginine vasopressin plays an important role in CVS. We detected morphological and radiological recovery in basilar artery, besides moderate improvement due to AV receptor antagonist in CVS.

Multiple intracranial tumors: Coexistence of a glioblastoma and null cell pituitary adenoma within the same patient

The coexistence of a glioblastoma multiforme and a null ell pituitary adenoma within the same patient is presented. lthough brain tumors are diagnosed in a slightly increasing umber of patients, due to a broader availability of computer omography andmagnetic resonance imaging (MRI), the estimated requency of primary brain tumors per year is as low as about 6–8 atients/100,000people.Moreover, simultaneousexistencesofpriary brain tumors with different pathologies were described in ot more than 0.9% of all primary brain tumors, but the majorty of those cases were seen after radiotherapy or are associated ith familial tumor syndromes [1,3]. Furthermore it is known that n phacomatosis syndromes, mesodermal and neuroectodermal umors can be seen together and occurrences of an ependymoma, hromophobe pituitary adenoma and an astrocytoma in those atients have been reported elsewhere [4]. But to our knowledge, his is the only case with two intracranial tumors of an essentially ifferent histopathological nature within the same patient, who oes not suffer from any known germ line mutation.