Sébastien Ratel

Muscle Fatigue during High-Intensity Exercise in Children

AbstractChildren are able to resist fatigue better than adults during one or several repeated high-intensity exercise bouts. This finding has been reported by measuring mechanical force or power output profiles during sustained isometric maximal contractions or repeated bouts of high-intensity dynamic exercises. The ability of children to better maintain performance during repeated high-intensity exercise bouts could be related to their lower level of fatigue during exercise and/or faster recovery following exercise. This may be explained by muscle characteristics of children, which are quantitatively and qualitatively different to those of adults.Children have less muscle mass than adults and hence, generate lower absolute power during high-intensity exercise. Some researchers also showed that children were equipped better for oxidative than glycolytic pathways during exercise, which would lead to a lower accumulation of muscle by-products. Furthermore, some reports indicated that the lower ability of children to activate their type II muscle fibres would also explain their greater resistance to fatigue during sustained maximal contractions.The lower accumulation of muscle by-products observed in children may be suggestive of a reduced metabolic signal, which induces lower ratings of perceived exertion. Factors such as faster phosphocreatine resynthesis, greater oxidative capacity, better acid-base regulation, faster readjustment of initial cardiorespiratory parameters and higher removal of metabolic by-products in children could also explain their faster recovery following high-intensity exercise.From a clinical point of view, muscle fatigue profiles are different between healthy children and children with muscle and metabolic diseases. Studies of dystrophic muscles in children indicated contradictory findings of changes in contractile properties and the muscle fatigability. Some have found that the muscle of boys with Duchenne muscular dystrophy (DMD) fatigued less than that of healthy boys, but others have reported that the fatigue in DMD and in normal muscle was the same. Children with glycogenosis type V and VII and dermatomyositis, and obese children tolerate exercise weakly and show an early fatigue. Studies that have investigated the fatigability in children with cerebral palsy have indicated that the femoris quadriceps was less fatigable than that of a control group but the fatigability of the triceps surae was the same between the two groups.Further studies are required to elucidate the mechanisms explaining the origins of muscle fatigue in healthy and diseased children. The use of non-invasive measurement tools such as magnetic resonance imaging and magnetic resonance spectroscopy in paediatric exercise science will give researchers more insight in the future.

Effect of physical activity intervention on body composition in young children: influence of body mass index status and gender.

Aim: To fight overweight and obesity in childhood, this study proposes an additional physical activity (PA) in young children aged 6–10 years. The objective was to evaluate the effect of school‐based PA on the body composition according to body mass index (BMI) categories (nonobese vs. obese) and gender.

Effect of Maturation on the Relationship between Muscle Size and Force Production

PURPOSE Although it is well accepted that an increase in muscle size is linked to an increase in muscle force, the relationship between muscle size and maximal strength during maturation is still discussed. In the present study we aimed at determining whether maturation affects the relationship between muscle size and maximal strength, and we investigated the reasons accounting for the discrepancies among previous studies. METHODS Maximal isometric handgrip force (Fmax) and forearm muscle size were measured in 14 prepubertal boys (11.3 +/- 0.8 yr old), 16 adolescents (13.3 +/- 1.4 yr old), and 16 men (35.4 +/- 6.4 yr old). Anatomic maximal cross-sectional area (MCSA) and muscle volume (VM) were measured using MRI, and these results were compared with muscle volume (VL) obtained from anthropometric measurements. RESULTS Fmax was linearly correlated with VM (r2 = 0.90), VL (r2 = 0.85), and MCSA (r2 = 0.87), while VM was strongly correlated with VL (r2 = 0.90). The Fmax/VM ratio did not differ among groups, whereas Fmax/VL and Fmax/MCSA ratios were significantly higher in adults than in children and adolescents. These results demonstrated that, when compared with MRI, anthropometric measurements led to a systematic overestimation of muscle volume. In addition, this overestimation was significantly larger in children (43.1%) and adolescents (38.5%) as compared with adults (20.5%) (P < 0.05). CONCLUSION Our results showed that the maximal isometric strength exerted by the forearm muscles in humans is proportional to their size whatever the age, and that VM is the best index of muscle size during growth. The previously reported increased ability to produce maximal strength from childhood to adulthood could be explained by systematic bias introduced by the method used to characterize muscle size instead of physiological or neural changes.

Muscle energetics changes throughout maturation: a quantitative 31P-MRS analysis.

We quantified energy production in 7 prepubescent boys (11.7 ± 0.6 yr) and 10 men (35.6 ± 7.8 yr) using (31)P-magnetic resonance spectroscopy to investigate whether development affects muscle energetics, given that resistance to fatigue has been reported to be larger before puberty. Each subject performed a finger flexions exercise at 0.7 Hz against a weight adjusted to 15% of their maximal voluntary strength for 3 min, followed by a 15-min recovery period. The total energy cost was similar in both groups throughout the exercise bout, whereas the interplay of the different metabolic pathways was different. At the onset of exercise, children exhibited a higher oxidative contribution (50 ± 15% in boys and 25 ± 8% in men, P < 0.05) to ATP production, whereas the phosphocreatine breakdown contribution was reduced (40 ± 10% in boys and 53 ± 12% in men, P < 0.05), likely as a compensatory mechanism. The anaerobic glycolysis activity was unaffected by maturation. The recovery phase also disclosed differences regarding the rates of proton efflux (6.2 ± 2.5 vs. 3.8 ± 1.9 mM · pH unit(-1) · min(-1), in boys and men, respectively, P < 0.05), and phosphocreatine recovery, which was significantly faster in boys than in men (rate constant of phosphocreatine recovery: 1.3 ± 0.5 vs. 0.7 ± 0.4 min(-1); V(max): 37.5 ± 14.5 vs. 21.1 ± 12.2 mM/min, in boys and men, respectively, P < 0.05). Our results obtained in vivo clearly showed that maturation affects muscle energetics. Children relied more on oxidative metabolism and less on creatine kinase reaction to meet energy demand during exercise. This phenomenon can be explained by a greater oxidative capacity, probably linked to a higher relative content in slow-twitch fibers before puberty.

Comparative analysis of skeletal muscle oxidative capacity in children and adults: a 31P-MRS study

The aim of the present study was to compare the oxidative capacity of the forearm flexor muscles in vivo between children and adults using 31-phosphorus magnetic resonance spectroscopy. Seven boys (11.7 +/- 0.6 y) and 10 men (35.6 +/- 7.8 year) volunteered to perform a 3 min dynamic finger flexions exercise against a standardized weight (15% of the maximal voluntary contraction). Muscle oxidative capacity was quantified on the basis of phosphocreatine (PCr) post-exercise recovery kinetics analysis. End-of-exercise pH was not significantly different between children and adults (6.6 +/- 0.2 vs. 6.5 +/- 0.2), indicating that indices of PCr recovery kinetics can be reliably compared. The rate constant of PCr recovery (kPCr) and the maximum rate of aerobic ATP production were about 2-fold higher in young boys than in men (kPCr: 1.7 +/- 1.2 vs. 0.7 +/- 0.2 min(-1); Vmax: 49.7 +/- 24.6 vs. 29.4 +/- 7.9 mmol.L(-1).min(-1), p < 0.05). Our results clearly illustrate a greater mitochondrial oxidative capacity in the forearm flexor muscles of young children. This larger ATP regeneration capacity through aerobic mechanisms in children could be one of the factors accounting for their greater resistance to fatigue during high-intensity intermittent exercise.

Age differences in human skeletal muscle fatigue during high-intensity intermittent exercise

It has been shown at similar relative work rates that children have higher resistance to fatigue than adults during repeated bouts of high‐intensity exercise. This age‐related difference in fatigue resistance may be explained by factors including muscle mass, muscle morphology, energy metabolism and neuromuscular activation.

Postexercise heart rate recovery in children: relationship with power output, blood pH, and lactate

The aim of the present study was to determine whether differences in age-related heart rate recovery (HRR) kinetics were associated with differences in power output, blood lactate concentration ([La]b), and acidosis among children, adolescents, and adults. Ten prepubertal boys (aged 9.6 +/- 0.7 years), 6 pubertal boys (aged 15.2 +/- 0.8 years), and 7 men (aged 20.4 +/- 1.0 years) performed 10 repeated 10-s all-out cycling sprints, interspersed with 5-min passive recovery intervals. Mean power output (MPO) was measured during each sprint, and HRR, [La]b, and acidosis (pHb) were determined immediately after each sprint. Children displayed a shorter time constant of the primary component of HRR than adolescents and adults (17.5 +/- 4.1 vs. 38.0 +/- 5.3 and 36.9 +/- 4.9 s, p < 0.001 for both), but no difference was observed between adolescents and adults (p = 1.00). MPO, [La]b, and pHb were also lower in children compared with the other 2 groups (p < 0.001 for both). When data were pooled, HRR was significantly correlated with MPO (r = 0.48, p < 0.001), [La]b (r = 0.58, p < 0.001), and pHb (r = -0.60, p < 0.001). Covarying for MPO, [La]b, or pHb abolished the between-group differences in HRR (p = 0.42, p = 0.19, and p = 0.16, respectively). Anaerobic glycolytic contribution and power output explained a significant portion of the HRR variance following high-intensity intermittent exercise. The faster HRR kinetic observed in children appears to be related, at least in part, to their lower work rate and inherent lack of anaerobic metabolic capacity.

Measurement error in short-term power testing in young people

The aim of this study was to examine the consistency or reproducibility of measuring cycling peak power in children and adults. Twenty-seven pre-pubertal girls and boys and 27 female and male physical education students (age 9.8±0.5 and 24.4±4.3 years, respectively; mean±s) participated in the study. All participants performed five tests over 15 days and underwent a habituation session before the study. Each test included four sprints against four different braking forces. We found that braking forces of 7.5% of body weight in children and 10% of body weight in adults were too high for most of the participants to elicit maximal cycling power. Unlike the children, the physical education students improved their performance between session 1 and session 2 (1025±219 vs 1069±243 W; P<0.001). Therefore, to obtain reproducible measures of cycling peak power, a habituation session including a complete test protocol (i.e. warm-up plus three sprints) is highly recommended. When the protocol included three sprints in children and at least two sprints in adults, measurement of cycling peak power was found to be highly reliable (test-retest coefficient of variation ∼3%). Finally, to avoid performance fluctuations, especially over several consecutive evaluations (e.g. longitudinal studies), it is necessary to maintain high motivation in children.

Four-Month Course of Soluble Milk Proteins Interacts With Exercise to Improve Muscle Strength and Delay Fatigue in Elderly Participants

BACKGROUND The benefit of protein supplementation on the adaptive response of muscle to exercise training in older people is controversial. OBJECTIVE To investigate the independent and combined effects of a multicomponent exercise program with and without a milk-based nutritional supplement on muscle strength and mass, lower-extremity fatigue, and metabolic markers. DESIGN A sample of 48 healthy sedentary men aged 60.8 ± 0.4 years were randomly assigned to a 16-week multicomponent exercise training program with a milk-based supplement containing, besides proteins [total milk proteins 4 or 10 g/day or soluble milk proteins rich in leucine (PRO) 10 g/day], carbohydrates and fat. Body composition, muscle mass and strength, and time to task failure, an index of muscle fatigue, were measured. Blood lipid, fibrinogen, creatine phosphokinase, glucose, insulin, C-reactive protein, interleukin-6, tumor necrosis factor-α soluble receptors, and endothelial markers were assessed. RESULTS Body fat mass was reduced after the 4-month training program in groups receiving 10 g/day of protein supplementation (P < .01). The training program sustained with the daily 10 g/day PRO was associated with a significant increase in dominant fat free mass (+5.4%, P < .01) and in appendicular muscle mass (+4.5%, P < .01). Blood cholesterol was decreased in the trained group receiving 10 g/day PRO. The index of insulin resistance (homeostasis model assessment-insulin resistance) and blood creatine phosphokinase were reduced in the groups receiving 10 g/day PRO, irrespective of exercise. The inflammatory and endothelial markers were not different between the groups. Training caused a significant improvement (+10.6% to 19.4%, P < .01) in the maximal oxygen uptake. Increased maximum voluntary contraction force was seen in the trained groups receiving 10 g/day of proteins (about 3%, P < .05). Time to task failure was improved in the trained participants receiving a 10 g/day supplementation with PRO (P < .01). CONCLUSIONS Soluble milk proteins rich in leucine improved time to muscle failure and increase in skeletal muscle mass and strength after prolonged multicomponent exercise training in healthy older men.

High-intensity and Resistance Training and Elite Young Athletes

Although in the past resistance and high-intensity exercise training among young children was the subject of numerous controversies, it is now well-documented that this training mode is a safe and effective means of developing maximal strength, maximal power output and athletic performance in youth, provided that exercises are performed with appropriate supervision and precautions. Muscular strength and power output values measured from vertical jump and Wingate anaerobic tests are higher in elite than in non-elite young athletes and normal children, and the specific training effects on maximal power output normalised for body size are clearly more distinct before puberty. At present, there is no scientific evidence to support the view that high-intensity and/or resistance training might hinder growth and maturation in young children. Pre-pubertal growth is not adversely affected by sport at a competitive level and anthropometric factors are of importance for choice of sport in children. However, coaches, teachers and parents should be aware that unsupervised high-intensity and resistance training programmes involving maximal loads or too frequently repeated resistance exercises increase the risk of injury. Resistance training alone is an effective additional means of developing athletic performance throughout planned youth sports training programmes. Strategies for enhancing the effectiveness and safety of youth resistance and high-intensity exercise training are discussed in this chapter.