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Portal vein thrombosis related to Cassia angustifolia

Introduction. Cassia angustifolia (Senna), used as a laxative, is a plant from the Fabaceae family. It includes hydroxyanthracene glycosides, also known as Senna Sennoside. These glycosides stimulate the peristalsis of the colon and alter colonic absorption and secretion resulting in fluid accumulation and expulsion. In the literature, there are repots illustrating the hepatotoxic effects of Cassia angustifolia but there is no report of portal vein thrombosis caused by Cassia Angustifolia. Case Report. A 42-year-old woman was admitted to the emergency department with a five-day history of worsening epigastric pain, anorexia, episodic vomiting, and intermittent fever. She reported that she had boiled dried senna leaves she had bought from herbalists and drank approximately 200 mL daily for two years. Color Doppler screening found an echogen thrombus obliterating portal vein bifurcation and the right branch. The lumen was obstructed at this level and there was no blood flow through it. Treatment with thrombolytics was unsuccessful. Discussion. Severe hepatotoxicity senna use is unusual. The cause of senna-related hepatotoxicity is unclear but could be explained by the exposure of the liver to unusual amounts of toxic metabolites of anthraquinone glycosides. Conclusion. Chronic use of Cassia angustifolia may rarely be associated with portal vein thrombosis.

Sonographic diagnosis of epiglottal enlargement

The case is presented of epiglottal and pre-epiglottal oedema secondary to infection of the pharyngolaryngeal area. The purpose of this report was to assess the utility of ultrasonography to image epiglottal and pre-epiglottal oedema. Bedside emergency department ultrasonography could be a valuable tool to detect pathological enlargement of the epiglottis. Ultrasonography may be used in unstable patients for diagnosing epiglottitis because it is cheap, rapid, non-invasive and does not aggravate the patients symptoms.

Contribution of goal-directed ultrasonography to clinical decision-making for emergency physicians.

Objective: To determine the contribution of goal-directed right upper quadrant (RUQ) ultrasonography (US) on real-time decision-making of attending emergency physicians by evaluating their level of certainty for admission, surgery, medical treatment, additional laboratory and radiological investigations and discharge. Methods: The study was conducted at an urban university tertiary care emergency department with an annual census of 60 000 adult patients. Patients with acute non-traumatic RUQ pain presenting to the emergency department during the 8-month study period were enrolled into the study. Primary outcome measures were level of certainty for admission to the hospital, emergency surgery, medical treatment, additional laboratory and radiological analyses and discharge from the emergency department. Results: There was a significant difference between the pre-US and post-US certainty of the decision to perform additional diagnostic studies (56 vs 72, p = 0.01) but not in the other outcomes (treatment, admission, surgery and discharge). After categorising the physicians’ decisions into low, intermediate and high, US had an effect on all primary outcomes and on all categories. This effect was most evident in the moderate category where the physicians were undecided for all primary outcomes. Conclusion: US performed by emergency department physicians affects the certainty of their decisions in patients presenting with RUQ pain. This effect is more evident on the decision to perform additional diagnostic studies and in patients about whom physicians are undecided.

The Value of Procalcitonin, a Novel Inflammatory Marker, in the Diagnosis of Myocardial Infarction and Evaluation of Acute Coronary Syndrome Patients

BACKGROUND Procalcitonin is a calcitonin precursor that is used as an inflammatory biomarker in the plasma of patients with sepsis. OBJECTIVE The aim of this study was to determine the diagnostic accuracy of emergency department (ED) point-of-care blood procalcitonin testing in identifying myocardial infarction (MI) in patients with chest pain of presumed ischemic origin. METHODS Patients over 18 years of age who presented to the ED with MI-typical chest pain of presumed ischemic origin were included in the study. An initial point-of-care blood sample was drawn from each study patient for testing procalcitonin, troponin T, myoglobin, and creatine kinase-MB levels. A second sample was taken 4h after admission for a procalcitonin test. Finally, a 6-h post-admission blood sample was taken to measure troponin T, myoglobin, and creatine kinase-MB levels in each study patient who had an initial negative cardiac marker test. RESULTS A total of 1008 patients with chest pain were admitted to the ED during the study period, and a total of 141 patients met study criteria and were entered into the study. ED point-of-care blood procalcitonin testing to identify myocardial infarction in patients with chest pain of presumed ischemic origin had a sensitivity of 38.3% (95% confidence interval [CI] 28.8-47.3%) and a specificity of 77.8% (95% CI 70.0-84.4%), a positive likelihood ratio (LR+) of 1.725 and a negative likelihood ratio (LR-) of 0.792. The 4th hour diagnostic values (sensitivity, specificity, LR+ and LR-) of procalcitonin semi-quantitative (PCT-Q) testing were 90% (95% CI 80.9-95.7%), 59.3% (95% CI 52.5-63.5%), 2.2, and 0.16, respectively. CONCLUSION ED point-of-care testing for procalcitonin had poor diagnostic accuracy for predicting myocardial infarction.

Pseudoaneurysm of the anterior tibial artery detected by emergency medicine physician performing bedside ultrasound.

We present the case of an anterior tibial artery pseudoaneurysm secondary to lacerating trauma caused by a straight-edge trimming blade. A 56-year-old man presented to emergency department (ED) with 1-month history of left calf pain. Thirty days before presentation, the patient lacerated his left lateral pretibial area with a cutting blade--similar to a machete--while cutting grass. He was seen at the state hospital, and primary suture was performed. Ten days later, the suture was removed. A week later, the patient revisited his physician, complaining of swelling and tenderness in the left calf. Hematoma formation of the calf was suspected and aspirated by syringe. Three days later, the patient presented to the ED with a repeat of his symptoms. On physical examination, the calf was swollen and tender. The vascular examination revealed a palpable dorsalis pedis and diminished posterior tibialis pulse. Localized swelling was present, and circumference of the affected calf was increased. No pulsatile mass was palpated. Ultrasound (US) performed at the bedside revealed a pulsating anechoic lesion surrounded by a hypoechoic lesion suggestive of thrombus formation. Doppler US of the patient showed 4.5x2.5-cm partially thrombosed pseudoaneurysm of the anterior tibial artery. In this case, the pseudoaneurysm was believed to be compressing the posterior tibial artery, resulting in a diminished pulse on examination. Emergency US use may enhance emergency physician performance by the shortening of the length of stay in the ED, reduce the number of unnecessary tests to be ordered, and hasten critical therapeutic interventions.

Abamectin intoxication with coma and hypotension

Abamectin is a potent antihelmintic, insecticide, and miticide used to control pests of humans, veterinary animals, and crops. The toxic effects of abamectin are usually seen after oral ingestions. These are altered mental status, respiratory failure, and hypotension. We report a case of acute abamectin intoxication who presented with altered mental status to the emergency department after oral ingestion.

Artificial neural network in predicting craniocervical junction injury: an alternative approach to trauma patients.

Objective The aim of this study is to determine the efficiency of artificial intelligence in detecting craniocervical junction injuries by using an artificial neural network (ANN) that may be applicable in future studies of different traumatic injuries. Materials and methods Major head trauma patients with Glasgow Coma Scale ≤8 of all age groups who presented to the Emergency Department were included in the study. All patients underwent brain computerized tomography (CT), craniocervical junction CT, and cervical plain radiography. A feedforward with back propagation ANN and a stepwise forward logistic regression were performed to test the performances of all models. Results A total of 127 patients fulfilling inclusion criteria were included in the study. The mean age of the study patients was 31±17.7, 77.2% (n=98) of them were male, 13.4% of the patients (n=17) had craniocervical junction pathologies. About 64.7% (n=11) of these pathologies were detected only by CT; 23.5% (n=4) of them by both craniocervical CT and cervical plain radiography; and 11.8% (n=2) of them only by cervical plain radiography. A logistic regression model had a sensitivity of 11.8% and specificity of 99.1%. Positive predictive value was 66.7% and negative predictive value was 87.9%. Area under the curve for logistic regression model was 0.794 (P=0.000). ANN had a sensitivity of 82.4% and specificity of 100%. Positive predictive value was 100% and negative predictive value was 97.3%. Area under the curve for ANN model was 0.912 (P=0.000). Conclusion ANN as an artificial intelligence application seems appropriate for detecting and excluding craniocervical junction injury but it should not replace craniocervical junction CT. However, these findings should lead us to test the applicability of ANN on hard-to-diagnose trauma patients or in constructing clinical decision rules.

Inhalational and dermal injury due to explosion of calcium hypochlorite

Calcium hypochlorite is a yellow-white powder widely used as a disinfectant in swimming pools. It releases chlorine gas when added to water and can cause respiratory effects. Dermal and eye injury can occur because of the caustic nature of chlorine. We report a case of chlorine toxicity and burns on a man’s face due to the explosion of calcium hypochlorite while he was mixing it into the water.

Pseudoaneurysm of the superficial femoral artery detected by emergency medicine bedside ultrasound

BackgroundFemoral artery pseudoaneurysm following by cardiac catheterization is a serious groin complication requiring careful assessment and prompt intervention.AimsRisk of femoral artery pseudoaneurysm is estimated at 0.6 to 17 following diagnostic and interventional procedures.MethodsThe clinical usage of bedside ultrasonography as part of the physical examination by attending emergency physicians has increased significantly over recent years.ResultsBedside Emergency Department ultrasonography provides the clinician with critical information noninvasively, rapidly determining various anatomical structures.ConclusionsWe presented the case of a femoral artery pseudoaneurysm detected by the bedside emergency department ultrasonography secondary to angiographic catheterization.

An unusual syncope cause in the ED: Favism

Favism is an acute hemolytic syndrome occurring in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals after the consumption of fava beans. The highest incidence is in boys aged 2-6 years. We report a 56-year-old man presented to the emergency department (ED) with recurrent syncope attacks due to favism. In our knowledge, this is the first report of favism-caused syncope in an adult patient without a G6PD deficiency diagnosis in the past and diagnosed in ED.