Sedat Caner

The relationship between microvascular complications and vitamin D deficiency in type 2 diabetes mellitus.

BackgroundVitamin D deficiency is reported as a possible risk factor for the development of diabetes in several epidemiologic studies. In this study, we investigated the frequency of 25-OH vitamin D deficiency in type 2 diabetes mellitus and the relationship between 25-OH vitamin D deficiency and the prevalence of microvascular complications.MethodsIn this retrospective study, we evaluated the medical records of 557 patients with type 2 diabetes admitted to the Endocrinology Outpatient Clinic from January to March 2010 and 112 healthy controls randomly selected from individuals admitted to the hospital for a check-up and who had a laboratory result for serum 25-OH vitamin D concentrations at screening. The levels of 25-OH vitamin D in patients with type 2 diabetes and the relationship between 25-OH vitamin D deficiency and microvascular complications were investigated.ResultsNo significant difference in serum 25-OH vitamin D concentrations was observed between the diabetic and control groups. No correlation was observed between HbA1C and serum 25-OH vitamin D levels. Serum 25-OH vitamin D levels were lower in diabetic patients with nephropathy, and patients not using any medication, i.e., those treated with dietary changes alone, had a higher prevalence of nephropathy.ConclusionVitamin D deficiency is more common in diabetic patients with nephropathy. When microvascular complications were evaluated, vitamin D levels were found to be lower in patients in whom these complications were more severe. Vitamin D deficiency is therefore associated with microvascular complications in diabetic patients.

Is IL-33 useful to detect early stage of renal failure?

Abstract IL-33 is a proinflammatory cytokine that is a member of IL-1 family. Previously the effect of IL-33 on kidney injury is showed in animal models. In this study, we searched if we can use IL-33 to show the early stage of kidney injury in diabetic patients. Three groups are identified: 26 patients in Group 1: Healthy group, that do not have any chronic diseases and not taking any medication; 42 patients in Group 2: DM (diabetes mellitus) group without any known kidney disease and with normal kidney functions; 32 patients in Group 3: DM + MA (microalbuminuria) group that are assumed to have nephropathy. IL-33 level of DM patient group is greater than healthy group; also IL-33 level of DM + MA patient group is greater than healthy group; but there is not any difference between DM and DM + MA group. The increase in IL-33 levels in diabetic nephropathy is not associated with kidney injury but the increase could be resulting because of diabetes. So IL-33 cannot be used in early recognition of diabetic nephropathy.

M30 Does Not Predict the Severity of Hepatosteatosis, Whereas Adiponectin Level Declined With Increase of ALT and the Severity of Hepatic Steatosis

Nonalcoholic fatty liver disease (NAFLD) is an emerging problem all over the world. Because NAFLD and polycystic ovary syndrome (PCOS) are both closely related with insulin resistance, it would be necessary to determine the rate of presence of NAFLD in PCOS patients. So, this study aimed to investigate the utility of M30 in PCOS patients for the diagnosis of hepatic injury.

Mean platelet volume (MPV): could it be used as a predictive marker for gestational diabetes? -

An abnormal glucose tolerance which is first detected during pregnancy and disappears after completion of pregnancy is known as “gestational diabetes mellitus”. Early detection of this condition helps preventing potential maternal and fetal complications. Some studies reported that platelets may have a role in the pathogenesis and development of gestational diabetes. In the present study, we aimed to evaluate and compare the platelet function and morphology among pregnant women with gestational diabetes and healthy pregnant women. Values of complete blood count were reviewed for pregnant women between weeks 24 and 28 of gestation while performing oral glucose tolerance tests for from January 2013 to September 2013. After screening, a total of 89 pregnant women were enrolled in the study including 38 women with gestational diabetes and 51 healthy pregnant women. The mean platelet volume (MPV) was 8.76 ± 1.53 fl in the group with gestational diabetes and 7.80 ± 1.34 fl in the healthy pregnant group, with a statistically significant difference between two groups (p=0.02). There was no statistically significant difference between two groups in platelet counts (p=0.25). Dissimilar results were reported by a small number of studies on this subject. MPV and other platelet parameters may be considerably helpful in detecting diabetic pregnant women who are at risk for vascular complications. In this study, significantly greater MPV was found among pregnant women with gestational diabetes compared to control group (p

What is the effect of radioiodine therapy on Helicobacter pylori infection

BACKGROUND/AIM Helicobacter pylori is an important human pathogen associated with gastric and duodenal ulcers, gastric mucosa- associated lymphoid tissue lymphoma, and adenocarcinoma. Radioiodine (RAI) treatment plays an important role in the management of differentiated thyroid cancer and primary hyperthyroidism. It is known that during RAI treatment, a considerable amount is absorbed by the stomach as well. In this study we aimed to reveal any therapeutic impact of RAI on H. pylori infections. MATERIALS AND METHODS Eighty-seven patients who were hospitalized for RAI treatment were consecutively included in this study. Of those, 76 patients had differentiated thyroid cancer and 11 had primary hyperthyroidism. The urea breath test (UBT) was performed on the day before RAI, and the test was repeated after 2 months. RESULTS The dose of RAI was 115 ± 3.3 mCi (range: 100-150 mCi) in the patients with malignant disease and 22.7 ± 1.4 mCi (range: 20-30 mCi) in the remaining patients. Among the patients with differentiated thyroid cancer, 44 (57%) had positive and 32 (43%) had negative UBT tests prior to RAI. Four (36%) patients with hyperthyroidism had pretreatment positive UBT tests and 7 (64%) had negative tests. The results of UBT conducted 2 months after RAI therapy were identical in every patient, which means that none of the patients with positive UBT became UBT-negative (P = 1). CONCLUSION RAI does not have any therapeutic effect on H. Ovlori infection.

Thyroid hemiagenesis: report of two cases and literature review -

Hemiagenesis of the thyroid gland is a rare anomaly in which one thyroid lobe fails to develop during embriological development. Only during investigations for other thyroid diseases leads to the occasional detection of thyroid hemiagenesis. Although hemiagenesis of the thyroid gland is a benign condition, most of the patients reported as having thyroid hemiagenesis had several thyroid disorders.

Akut böbrek yetmezliği gelişen yoğun bakım hastalarında Rifle kriterlerinin uygulanması ve prognoza etki eden faktörlerin değerlendirilmesi

1 Atatürk Eğitim ve Araştırma Hastanesi Endokrinoloji Kliniği, Ankara, Türkiye 2 Başkent Üniversitesi İç Hastalıkları Kliniği, Ankara, Türkiye 3 Başkent Üniversitesi Nefroloji Anabilim Dalı, Ankara, Türkiye Yazışma Adresi /Correspondence: Celil Alper Usluoğulları, Dr Ersin Arslan Devlet Hastanesi Gaziantep, Türkiye Email: calperuslu@yahoo.com Geliş Tarihi / Received: 22.05.2013, Kabul Tarihi / Accepted: 21.06.2013 Copyright