Sedef Sahin
Hacettepe University
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Publication
Featured researches published by Sedef Sahin.
Journal of The American Academy of Dermatology | 1998
Sedef Sahin; Ludmila Levin; Alfred W. Kopf; Babar K. Rao; Marc Triola; Karen L. Koenig; Carol L Huang; Robert S. Bart
BACKGROUND The risk of the occurrence of malignant melanoma (MM) in medium-sized (1.5 to 19.9 cm in diameter) congenital melanocytic nevi (CMN) is the subject of controversy. Universally accepted recommendations regarding the management of such lesions have not been made. OBJECTIVE Our purpose was to assess the risk of MM arising in medium-sized CMN. METHODS The study included 230 medium-sized CMN in 227 patients, first seen in a private dermatology practice from 1955 to 1996, who were followed up for MM arising within their CMNs. Criteria for entry into the study included (1) a clinically diagnosed medium-sized CMN, (2) minimum follow-up period of 1 year, and (3) a photograph of the lesion in the patients medical record. RESULTS No MM occurred in a medium-sized CMN during an average follow-up of 6.7 years (median, 5.8 years) to an average age of 25.5 years (median, 19.1 years). CONCLUSION The results of this short-term follow-up study do not support the view that there is a clinically significantly increased risk for MM arising in banal-appearing medium-sized CMN or that prophylactic excision of all such lesions is mandatory. Lifelong medical observation seems a reasonable alternative for many medium-sized CMN.
Pediatric Dermatology | 2004
Deniz Seçkin; Cicek Durusoy; Sedef Sahin
Abstract: Well‐known cutaneous side effects of interferon (IFN)‐alfa therapy include dry skin, pruritus, hair loss, and psoriasis. Presumably because of its potent immunomodulatory activity, the use of IFN‐alfa has also led to the development of autoimmune diseases in susceptible individuals. Vitiligo, an autoimmune cutaneous disease, has been reported to occur during IFN‐alfa therapy. We report a 10‐year‐old girl with chronic hepatitis B infection in whom IFN‐alfa treatment induced de novo development of vitiligo and psoriasis. Neither skin condition improved after withdrawal of interferon treatment. Concomitant occurrence of vitiligo and psoriasis due to IFN‐alfa has not been reported previously.
Photodermatology, Photoimmunology and Photomedicine | 2005
Simin Ada; Sedef Sahin; Gonca Boztepe; Ayşen Karaduman; Fikret Kölemen
Background/Purpose: There is no definite cure for vitiligo; however, treatment responses with photobiological modalities are quite acceptable. Of all these, narrow‐band UVB phototherapy was proposed rather recently. Calcipotriol has been shown to have stimulating activity on melanogenesis besides immunomodulatory and anti‐inflammatory effects. This study was performed to determine whether adding topical calcipotriol to narrow‐band UVB phototherapy enhances the efficacy of treatment.
Journal of The European Academy of Dermatology and Venereology | 2006
Gulsen Akoglu; Gül Erkin; Banu Cakir; Gonca Boztepe; Sedef Sahin; Ayşen Karaduman; Nilgün Atakan; T Akan; Fikret Kölemen
Background Mastocytosis is a rare, heterogeneous group of disorder with abnormal increase of mast cells in one or more organ systems.
International Journal of Dermatology | 2002
Nilgiin Senturk; Sedef Sahin; Tanil Kocagöz
Background Most cutaneous tuberculosis lesions contain few bacilli, so identification of Mycobacterium tuberculosis in conventional laboratory tests is difficult. In vitro amplification of specific DNA sequences using polymerase chain reaction (PCR) has become a valuable tool in the rapid detection of slow‐growing organisms like M. tuberculosis.
International Journal of Dermatology | 2006
Gonca Boztepe; Ayşen Karaduman; Sedef Sahin; Murat Hayran; Fikret Kölemen
Background Narrow‐band (311 nm) UVB is an effective treatment modality for moderate to severe psoriasis. The effect of maintenance narrow‐band UVB on the duration of remission is unknown.
Journal of The European Academy of Dermatology and Venereology | 1998
E Erkek; Sedef Sahin; Nilgün Atakan; Tanil Kocagöz; Ai Olut; Aytaç Gököz
The aetiology of cutaneous T‐cell lymphoma (CTCL) remains unknown despite numerous investigations. In recent years, retroviruses and human herpesviruses have been implicated to play a causal part in CTCL.
Dermatology | 2005
Gulsen Akoglu; Ayşen Karaduman; Gonca Boztepe; Özay Özkaya; Sedef Sahin; Gül Erkin; Fikret Kölemen
A 14-year-old boy presented with a pink firm plaque with well-defined borders in the right infra-orbital skin area. On diascopy, the infiltrate exhibited a typical apple-jelly appearance. No acid-fast bacilli could be demonstrated. A polymerase chain reaction (PCR) assay did not reveal the presence of mycobacteria in a lesional biopsy sample. Culture of biopsied tissue on Loewenstein-Jensen medium was negative. Although the tuberculosis culture and PCR did not confirm tuberculosis, a diagnosis of lupus vulgaris was made considering the clinical and histopathological findings. After a 9-month antituberculous therapy, the lesion disappeared. We believe that a diagnosis of lupus vulgaris still depends more on clinical and histopathological findings than on tuberculosis culture or PCR.
International Journal of Dermatology | 2008
Sevil Ozdöl; Sedef Sahin; Lale Tokgozoglu
Objectives To investigate the association between xanthelasma, atherosclerotic risk factors, and lipoprotein (Lp) (a), and to determine whether xanthelasma may be a cutaneous marker for atherosclerosis.
International Journal of Dermatology | 1999
Sedef Sahin; Uğur Hindioğlu; Ayşen Karaduman
Background Psoralen plus ultraviolet A (PUVA) is considered to be the treatment of choice for subtotal vitiligo; however, it is time consuming and carries certain health risks for both patients and physicians. This study attempts to evaluate the efficacy of the treatment in Turkish vitiligo patients.