Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Seenu M Hariprasad is active.

Publication


Featured researches published by Seenu M Hariprasad.


American Journal of Ophthalmology | 2001

Optic nerve blood flow is diminished in eyes of primary open-angle glaucoma suspects.

Jody R. Piltz-Seymour; Juan E. Grunwald; Seenu M Hariprasad; Joan DuPont

PURPOSE The purpose of this study was to evaluate optic nerve blood flow in primary open-angle glaucoma suspect eyes with normal automated visual fields, in an attempt to elucidate how early in the glaucomatous disease process changes in optic nerve blood flow become apparent. METHODS Twenty-one eyes (21 patients) suspected of having primary open-angle glaucoma were studied prospectively and compared with a previously reported cohort of 22 eyes (22 patients) with primary open-angle glaucoma and 15 eyes (15 subjects) of age-matched controls. Primary open-angle glaucoma suspect eyes had untreated intraocular pressure greater than 21 mm Hg and normal visual fields using Humphrey program 24-2 or 30-2 with a full threshold strategy. Laser Doppler flowmetry was used to measure optic nerve head blood velocity, volume, and flow at four quadrants in the optic nerve, in the cup, and in the foveola of one eye of each patient. The mean flow from the superotemporal rim, inferotemporal rim, and cup was calculated (Flow(3)) and identified as the main outcome measure. Measurements from primary open-angle glaucoma suspect eyes were compared with corresponding measurements from controls and eyes with primary open-angle glaucoma; a Student t test was employed with a Bonferroni corrected P value of.025 to account for comparisons of primary open-angle glaucoma suspects both to controls and to eyes with primary open-angle glaucoma. RESULTS Compared with controls, Flow(3) was 24% lower in primary open-angle glaucoma suspect eyes (P <.0003). In primary open-angle glaucoma suspect eyes, flow was 16% lower in the superotemporal rim (P <.007), 35% lower in the cup (P <.007), and 22% lower in the inferotemporal neuroretinal rim (P <.029) compared with controls. No significant difference between primary open-angle glaucoma suspect and control eyes was seen in the inferonasal rim, superonasal rim, or foveola. No significant difference was detected at any location between primary open-angle glaucoma suspect eyes and eyes with primary open-angle glaucoma. CONCLUSIONS Laser Doppler flowmetry detected circulatory abnormalities in primary open-angle glaucoma suspects who did not have any manifest visual field defect. Decreases in flow in glaucoma suspects were similar in magnitude to those of subjects with primary open-angle glaucoma. These data suggest that impaired optic nerve blood flow develops early in the glaucomatous process and does not develop solely as a result of glaucoma damage.


Clinical Ophthalmology | 2009

Treatment of cystoid macular edema with the new-generation NSAID nepafenac 0.1%.

Seenu M Hariprasad; Levent Akduman; Joseph A Clever; Michael Ober; Franco M. Recchia; William F. Mieler

Purpose: To describe the use of nepafenac 0.1% for cystoid macular edema (CME). Methods: This was a multicenter retrospective review of 22 CME cases (20 patients) treated with nepafenac 0.1% (six with concomitant prednisolone acetate 1%) from December 2005 to April 2008: three acute pseudophakic CME cases, 13 chronic/recalcitrant pseudophakic CME cases, and six cases of uveitic CME. Pre- and post-treatment retinal thickness and visual acuity were reported. Results: Following treatment for six weeks to six months, six eyes with uveitic CME showed a mean retinal thickness improvement of 227 ± 168.1 μm; mean best-corrected visual acuity (BCVA) improvement was 0.36 ± 0.20 logMAR. All three cases of acute pseudophakic CME improved after four to 10 weeks of nepafenac, with a mean improvement in retinal thickness of 134 ± 111.0 μm. BCVA improved in two patients (0.16 and 0.22 logMAR) but not in the third due to underlying retinal pigment epithelium changes. Thirteen eyes with chronic/recalcitrant pseudophakic CME demonstrated a mean improvement in retinal thickness of 178 ± 128.7 μm after nepafenac and mean BCVA improvement of 0.33 ± 0.19 logMAR. Conclusion: The positive outcomes of these 22 eyes strongly suggest that nepafenac 0.1% is a promising drug for the treatment of CME. Additional study under randomized controlled conditions is warranted.


Retina-the Journal of Retinal and Vitreous Diseases | 2005

Photodynamic therapy for juxtafoveal choroidal neovascularization due to ocular histoplasmosis syndrome.

Gaurav K. Shah; Kevin J. Blinder; Seenu M Hariprasad; Matthew A. Thomas; Edwin H. Ryan; Jeff Bakal; Sanjay Sharma

Purpose: To report the use of photodynamic therapy with verteporfin in patients with juxtafoveal choroidal neovascularization (CNV) for ocular histoplasmosis syndrome (OHS). Methods: Retrospective review. Data regarding the following variables were extracted from patient charts: demographic characteristics, previous surgeries, angiographic features, number and time of treatments, follow-up time, and change in visual acuity. Results: This study sample consisted of 23 eyes of 23 consecutive patients who were treated with photodynamic therapy for the management of juxtafoveal CNV. When post-treatment visual acuity (mean logMAR acuity = 0.321) was compared to baseline acuity (mean logMAR visual acuity = 3.89) vision improved by more than three Snellen lines in 30% of eyes, remained the same (±2 Snellen lines) in 52% of eyes, and worsened (greater than a two-line loss in visual acuity) in 18% of eyes. Although this series was uncontrolled, the patients had a trend toward a therapeutic benefit when compared to published natural history of similar cases (OR = 0.292, P value = 0.071 when compared to data from the Macular Photocoagulation Study for treatment of juxtafoveal lesions). Conclusion: Photodynamic therapy with verteporfin may be beneficial in patients with juxtafoveal CNV secondary to OHS in terms of both visual stabilization and improvement.


Ophthalmic Surgery and Lasers | 2014

Surgical management of proliferative diabetic retinopathy.

Sumit Sharma; Seenu M Hariprasad; Tamer H. Mahmoud

Indications for surgical intervention The indications for surgical intervention in patients with diabetic retinopathy are broad. The Diabetic Retinopathy Vitrectomy Study (DRVS) established the role of early surgery for patients with type 1 diabetes and vitreous hemorrhage.5-7 More recent data suggest that improvements in technique since the DRVS was completed have significantly improved visual outcomes in eyes with tractional retinal detachment due to both type 1 and 2 diabetes.8 Persistent non-clearing or recurrent vitreous hemorrhage should prompt consideration of vitrectomy depending on various factors, including degree of visual impairment, the visual status of the fellow eye, duration of hemorrhage, adequacy of previous panretinal photocoagulation (PRP), and presence of underlying tractional detachment involving or threatening the macula. The current trend is to observe patients with type 1 diabetes with new onset of vitreous hemorrhage for 1 month, and if no signs of clearing are seen, to proceed with surgery. Patients with type 2 diabetes can be monitored for a longer period of time for clearing, especially if adequate PRP has been performed and there are no signs of retinal detachment involving or threatening the macula. Dense premacular hemorrhage left untreated can result in macular tractional deSurgical management of proliferative diabetic retinopathy


Archives of Ophthalmology | 2011

Polyethylene Glycol Hydrogel Polymer Sealant for Vitrectomy Surgery: An In Vitro Study of Sutureless Vitrectomy Incision Closure

Seenu M Hariprasad; Ajay Singh

OBJECTIVE To test a novel hydrogel sealant to secure sutureless sclerotomies under variable intraocular pressure conditions. METHODS In cadaver eyes, 23- and 20-gauge (G) sclerotomies were constructed. Sixteen 23-G beveled sclerotomies were constructed in 4 eyes: 8 of the incisions were treated with hydrogel sealant, while 8 were left bare. All sclerotomies were monitored for leaks while the intraocular pressure was elevated. The pressure on incision leakage was recorded as the leak pressure (maximum tested = 140 mm Hg). Additionally, sixteen 20-G sclerotomies were constructed in 4 other eyes: 8 of the incisions were treated with hydrogel sealant, while 8 were sutured. These incisions were similarly pressure tested. RESULTS Among the 23-G incisions, hydrogel sealant application to the incisions significantly increased the leak pressure relative to bare incisions: mean (SE), 131.8 (8.2) vs 39.5 (5.2) mm Hg, respectively (P < .001). Only 1 of the 8 sealant-treated 23-G incisions leaked below 140 mm Hg, compared with all of the 8 bare incisions. Among the 20-G incisions, there was no difference in leak pressure among sealant-treated and sutured incisions: mean (SE), 140.0 (0.0) vs 136.3 (3.8) mm Hg, respectively (P = .35). None of the 8 sealant-treated 20-G incisions leaked below 140 mm Hg, compared with 1 of the 8 sutured incisions. CONCLUSIONS Hydrogel sealant significantly increased the leak pressure among 23-G incisions relative to 23-G bare incisions and was equivalent to suturing among 20-G incisions. CLINICAL RELEVANCE Hydrogel sealants effectively close vitrectomy incisions and may decrease the incidence of postoperative endophthalmitis and hypotony.


Ophthalmic Surgery and Lasers | 2014

ILM Peeling a Vital Intervention for Many Vitreoretinal Disorders

Harpreet S Walia; Gaurav K. Shah; Seenu M Hariprasad

The internal limiting membrane (ILM) is the structural interface between the vitreous and retina. As the basement membrane of retinal Müller cells, it serves as a protective barrier and provides biomechanical strength for the central retina.1-3 It also acts as a scaffold for cellular proliferation for myofibroblasts, fibrocytes, and retinal pigmented epithelial cells. ILM removal ensures separation of the posterior hyaloid from the macular surface, which can relieve macular traction4,5 and prevent postoperative epiretinal membrane formation.6,7 Thus, vitrectomy with ILM peeling has become an increasingly utilized and vital component in surgical intervention for various vitreoretinal disorders.


Ophthalmic Surgery and Lasers | 2017

An Overview of the Fovista and Rinucumab Trials and the Fate of Anti-PDGF Medications

Evan N Dunn; Seenu M Hariprasad; Veeral S. Sheth

SLACK Incorporated’s journal copyright agreements enable authors funded by the National Institutes of Health (NIH) to deposit their accepted manuscripts to PubMed Central for posting 12 months following publication by SLACK Incorporated. The agreement also allows posting of accepted manuscripts on authors’ institutional repositories, with the exception of open access repositories, 12 months following publication by SLACK Incorporated. Authors should include a link to the final published article on the journal website. SLACK Incorporated will retain copyright for these articles, which prohibits republication elsewhere, and SLACK Incorporated will retain the right to charge a fee for the final published versions of these articles in whatever format they appear.


Ophthalmic Surgery and Lasers | 2015

Geographic atrophy: clinical impact and emerging treatments.

Hershel R Patel; Seenu M Hariprasad; David Eichenbaum

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the developed world. Severe central visual impairment develops as a result of neovascular derangement (wet AMD) or non-neovascular abnormalities (dry AMD). Slight alterations in central visual acuity can have profound effects on activities of daily living such as reading or driving. Dry AMD, which constitutes 85% to 90% of cases, is clinically associated with large confluent drusen formation and hyperpigmentation, with subsequent resorption of drusen and eventual loss of retinal pigment epithelium (RPE), choriocapillaris, and photoreceptors, leading to geographic atrophy (GA).1,2 This advanced stage of dry AMD is responsible for 20% of all cases of legal blindness in North America.3 Geographic atrophy: clinical impact and emerging treatments


Ophthalmic Surgery and Lasers | 2014

Evolving Trends in Primary Retinal Detachment Repair: Microincisional Vitrectomy and the Role of OCT

Patrick D Williams; Seenu M Hariprasad

Retinal detachment repair continues to evolve toward less invasive techniques that can safely, efficiently, and consistently provide optimal outcomes. In fact, 53% of U.S. respondents to the American Society of Retinal Specialists 2013 Preferences and Trends Survey said they would perform a vitrectomy without scleral buckle to treat a retinal detachment with a superior tear, while 25% would perform pneumatic retinopexy, and 21% would use a scleral buckle with or without vitrectomy.11 Compared to in 2005, many more surgeons prefer vitrectomy-only repair, whereas fewer prefer scleral buckle. Interestingly, preferences toward pneumatic retinopexy have slightly declined, which may reflect increased confidence in vitrectomy surgery to repair a detached retina safely and efficiently as an alternative. Even complex detachments can be treated in a minimally invasive fashion with the improvements in instrumentation, trocars, and oil infusion. While trends will likely continue toward minimal invasiveness, some form of scleral buckle, vitrectomy, and pneumatic retinopexy will all persist as treatment options. OCT advancements may allow for individualized discussions of visual prognosis and surgical decision making without the need for any invasive testing.


Ophthalmic Surgery and Lasers | 2016

Evaluation of the Retinal and Choroidal Vasculature With OCT Angiography Versus Conventional Angiography

Colin S. Tan; Seenu M Hariprasad; Louis W. Lim; Srinivas R. Sadda

by Colin S. Tan, MBBS, MMed (Ophth), FRCSEd (Ophth), Louis W. Lim, MBBS, and SriniVas R. Sadda, MD The role of optical coherence tomography angiography (OCTA) in the evaluation of the retinal and choroidal vasculature is still evolving as we learn more about this fascinating technology. Since 2015, we have seen numerous papers published comparing OCTA to conventional fluorescein angiography (FA) and indocyanine green angiography (ICGA) to evaluate various disease states. Retina specialists are trying to process this flood of data as we lack a review of the literature regarding this topic. I asked Colin S. Tan, MBBS, MMed (Ophth), FRCSEd (Ophth), Louis W. Lim, MBBS, and SriniVas R. Sadda, MD, to provide us with an overview of the merits of each OCTA, FA, and ICGA in evaluating various retinal and choroidal diseases as well as other widely recognized retinal vascular features. They will also summarize for us the pros and cons of each of the three angiography methods. Obviously, OCTA is a very useful technology and its role will only increase as advances in processing algorithms continue. The insights and expertise that Drs. Tan, Lim, and Sadda share with us will be very helpful as we apply OCTA into our clinical practices. Optical coherence tomography angiography (OCTA) is an exciting new technology that promises to revolutionize the imaging of patients with various ocular conditions. OCT scans provide high-resolution structural detail of the retina and choroid. In contrast, OCTA allows visualization of blood flow within the layers of the retina and choriocapillaris.1,2 OCTA is based on the premise that blood corpuscles are moving within retinal vessels, whereas the surrounding structures are not.1,2 Stationary tissue shows high correlation in imaging characteristics from one frame to the next, whereas blood flowing through vessels causes changes in reflectance over time and localized areas of low correlation between frames. The motion of blood within vessels can be detected using phase/Doppler shift, amplitude variation, or a combination of these. OCTA uses rapidly performed OCT B-scans at the same location to analyze for variation, and processing algorithms then create vascular flow maps of the region. The advantage of OCTA is that it is a rapid, noninvasive, dyeless system that allows simultaneous assessment of structure and flow with better microvascular and depth resolution than conventional angiograms. In contrast, conventional angiograms require intravenous access, and fluorescein and indocyanine Colin S. Tan

Collaboration


Dive into the Seenu M Hariprasad's collaboration.

Top Co-Authors

Avatar

William F. Mieler

University of Illinois at Chicago

View shared research outputs
Top Co-Authors

Avatar

Gaurav K. Shah

Thomas Jefferson University

View shared research outputs
Top Co-Authors

Avatar

Joan DuPont

University of Pennsylvania

View shared research outputs
Top Co-Authors

Avatar

Juan E. Grunwald

University of Pennsylvania

View shared research outputs
Top Co-Authors

Avatar

Kevin J. Blinder

Washington University in St. Louis

View shared research outputs
Top Co-Authors

Avatar

Matthew A. Thomas

Washington University in St. Louis

View shared research outputs
Top Co-Authors

Avatar

Rajendra S. Apte

Washington University in St. Louis

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Nancy M. Holekamp

Washington University in St. Louis

View shared research outputs
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge