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Tetrahedron Letters | 1991

Synthesis and antiviral activity of oxetanocin derivatives

Masayuki Kitagawa; Shigeru Hasegawa; Seiichi Saito; Nobuyoshi Shimada; Tomohisa Takita

Abstract The sugar part of natural oxetanocin A was chemically modified. Some of the derivatives demonstrated strong antiviral activity against human immunodeficiency virus (HIV).


The Journal of Antibiotics | 1975

THE STRUCTURE OF A GLYOXALASE I INHIBITOR AND ITS CHEMICAL REACTIVITY WITH SH-COMPOUNDS

Hideo Chimura; Hikaru Nakamura; Tomohisa Takita; Tomio Takeuchi; Hamao Umezawa; Kuniki Kato; Seiichi Saito; Takayuki Tomisawa; Yoichi Iitaka


The Journal of Antibiotics | 1987

Derivatives of oxetanocin: Oxetanocins H, X and G, and 2-aminooxetanocin A.

Nobuyoshi Shimada; Shigeru Hasegawa; Seiichi Saito; Takaaki Nishikiori; Akio Fujii; Tomohisa Takita


Archive | 1988

Antibiotic NK86-0279, process for production of the same and application of the same

Takaaki Nishikiori; Masanori Yamazaki; Seiichi Saito; Nobuyoshi Shimada; Takashi Kurokawa; Kiyonobu Hirose; Takumi Yamshita; Takako Tsuchiya; Takashi Harada


Chemical & Pharmaceutical Bulletin | 1985

Synthetic Studies on an Antitumor Antibiotic, Bleomycin. XIV. The Synthesis of Boc-Pyrimidoblamic Acid

Masami Otsuka; Masatoshi Narita; Makoto Yoshida; Susumu Kobayashi; Masaji Ohno; Yoji Umezawa; Hajime Morishima; Seiichi Saito; Tomohisa Takita; Hamao Umezawa


The Journal of Antibiotics | 1983

An improved total synthesis of bleomycin.

Seiichi Saito; Yuji Umezawa; Takeo Yoshioka; Tomohisa Takita; Hamao Umezawa; Yasuhiko Muraoka


Bulletin of the Chemical Society of Japan | 1986

Studies on Glycosylation of erythro-β-Hydroxy-L-histidine. A Key Step of Bleomycin Total Synthesis

Toshiaki Miyake; Tsutomu Tsuchiya; Sumio Umezawa; Seiichi Saito; Hamao Umezawa


Archive | 1985

NEW ANALOGS AND DERIVATIVES OF BLEOMYCIN

Hamao Umezawa; Tomohisa Takita; Seiichi Saito; Yasuhiko Muraoka; Katsutoshi Takahashi; Hisao Ekimoto; Seiki Minamide; Kiyohiro Nishikawa; Takeyo Fukuoka; Tokuji Nakatani; Akio Fujii; Akira Matsuda


Archive | 1989

Oxetanocin-related compounds and process for producing same

Seiichi Saito; Shigeru Hasegawa; Katsutoshi Takahashi; Nobuyoshi Shimada; Jun-Ichi Seki; Hiroo Hoshino; Yukihiro Nishiyama; Kenichi Matsubara; Takemitsu Nagahata


Archive | 1989

Oxetanocin-related compounds and pharmaceutical compositions containing them

Seiichi Saito; Shigeru Hasegawa; Katsutoshi Takahashi; Nobuyoshi Shimada; Jun-Ichi Seki; Hiroo Hoshino; Yukihiro Nishiyama; Kenichi Matsubara; Takemitsu Nagahata

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