Seiichiro Kawabe

Biotransformation of 4-androstene-3,17-dione by green cell suspension of Marchantia polymorpha : stereoselective reduction at carbon 17

The biotransformation of 4-androstene-3,17-dione by a green cell suspension of Marchantia polymorpha was studied. It was found that the cultured cells stereoselectively reduce the carbonyl group of 4-androstene-3,17-dione from the re-face at C-17 to form testosterone as the primary metabolite.

Biotransformation of Paclitaxel by Cell Suspension Cultures of Eucalyptus Perriniana

Abstract Incubation of Eucalyptus perriniana cells in medium containing paclitaxel lead to the isolation of three taxoid derivatives which were identified by 1H NMR and MS spectrometry data as baccatin III, 10-deacetylbaccatin III and 2-debenzoyltaxol. No transformation occurs in medium without Eucalyptus cells.

Enantioselectivity in the reduction of α-dicarvelone by cell suspension cultures of Nicotiana tabacum

Abstract The biotransformation of the enantiomeric pairs of α-dicarvelone by cell suspension cultures of Nicotiana tabacum was investigated. It was found that the cultured cells transform only (1 R ,1′ R ,4 R ,4′ R ,6 R ,6′ R )-(+)-α-dicarvelone to the corresponding alcohol.