Sejal Patel

Copper-catalyzed decarboxylative C–N coupling for N-arylation

A novel approach for N-arylation utilizing aryl carboxylic acids as stable, inexpensive and widely available arylating reagents was developed. Employing a simple copper(II)–phenanthroline catalyst system, several benzoic acids bearing suitable ortho-substitutions undergo decarboxylative C–N cross-coupling effectively with various N-nucleophiles.

Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing

A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.