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HPV Types in Turkey: Multicenter Hospital Based Evaluation of 6388 Patients in Turkish Gynecologic Oncology Group Centers Türkiye'deki HPV Tipleri: Türk Jinekolojik Onkoloji Grubuna Üye Merkezlere Başvuran 6388 Hastanin Retrospektif Analizi

Abstract Objective: To evaluate the prevalence of HPV DNA and cervical cytological abnormalities, to compare cervical cytology results and HPV DNA and to define HPV types distribution in a large series of Turkish women who have undergone HPV analysis in hospitals that are members of the Turkish Gynecological Oncology Group. Material and Method: Between 2006 and 2010, a total of 6388 patients’ data was retrospectively evaluated at 12 healthcare centers in Turkey. Demographic characteristics, cervical cytology results, HPV status and types were compared. Results: The mean age of the patients was 38.9±10.2. Overall, 25% of the women were found to be HPV positive. Presence of HPV-DNA among patients with abnormal and normal cytology was 52% and 27%, respectively. There was significant difference with respect to decades of life and HPV positivity (p < 0.05). HPV was positive in (within the HPV (+) patients) 37%, 9%, 27%, 20%, 22%, and 41% of the ASCUS, ASC-H, LSIL HSIL, glandular cell abnormalities, and SCC cases respectively The most common HPV types in our study were as follows; HPV 16 (32%), HPV 6 (17%), HPV 11 (9%), HPV 18 (8%), HPV 31 (6%), HPV 51 (5%), HPV 33 (3%). Conclusion: In this hospital based retrospective analysis, HPV genotypes in Turkish women with normal and abnormal cytology are similar to those reported from western countries. Further population based prospective multicenter studies are necessary to determine non-hospital based HPV prevalence in Turkish women Öz Amaç: Türkiyedeki HPV tiplerinin geniş bir seri ile ortaya konması amacı ile Türk Jinekolojik Onkoloji grubuna üye hastanelerde HPV analizi yapılan hastaların sonuçlarının retrospektif olarak değerlendirilmesi ve sitolojik anormalliklerdeki HPV tiplerinin belirlenmesi. Gereç ve Yöntem: 2006 ve 2010 yılları arasında 12 ayrı merkeze başvuran smear ve HPV analizi yapılan toplam 6388 hasta retrospektif olarak incelenmiştir. Hastaların demografik bilgileri, smear sonuçları, HPV tipleri online olarak toplanıp analiz edilmiştir. Bulgular:Ortalama hasta yaşı 38.9±10.2 idi. Tüm grup değerlendirildiğinde, %25 hastada HPV pozitif olarak saptandı. Anormal sitolojisi olanlarda HPV pozitifliği %57 iken normal pap testi olanlarda HPV pozitifliği %27 oranında tespit edildi. Hastaların yaşam dekadları ile HPV pozitifliği arasında anlamlı bir ilişki bulundu (p<0,05) HPV pozitifliği ASCUS, ASC-H, LSIL, HSIL, glandüler anormallikler ve skuamöz hücreli karsinom için sırasıyla %37, %9, %27, %20, %22, %41 idi. En sık görülen HPV tipleri sırasıyla HPV 16 (%32), HPV 6 (%17), HPV 11 (%9), HPV 18 (%8), HPV 31 (%6), HPV 51 (%5), HPV 33 (%3) idi. Sonuç:Bu hastane temelli retrospektif analizde HPV tipleri gelişmiş batı ülkelerinde rapor edilen tiplerle benzer olarak tespit edildi. Ülkemizdeki gerçek popülasyon temelli HPV prevalansı ve tiplerinin belirlenmesi için hastane temelli olmayan çok merkezli geniş sayıda hasta içeren serilere ihtiyaç vardır

Role of postmenopausal bleeding pattern and women's age in the prediction of endometrial cancer

Women with postmenopausal bleeding should be evaluated efficiently to exclude endometrial carcinoma.

A reliable way to predict intraabdominal adhesions at repeat cesarean delivery: scar characteristics

Objective. To evaluate association between scar characteristics and intraabdominal adhesions at repeat cesarean delivery. Design. A prospective, cross‐sectional study. Setting. Tertiary Government Maternity Training Hospital in Ankara, Turkey. Population. 295 pregnant women with at least one prior cesarean delivery. Methods. All women were at least 36 weeks pregnant. Appearance of previous cesarean delivery scars was categorized into three groups – flat, depressed and elevated. Pigmentation status was also noted (non‐pigmented or pigmented). Main Outcome Measures. Intraoperatively detected adhesions, evaluated and classified into three groups (no adhesion, filmy adhesion and dense adhesion groups) by a modified Nairs classification. Results. Elevated scars had significantly more dense adhesion formation than depressed ones (31.4 vs. 12.7%, p=0.02). No difference was found for dense adhesions when depressed and flat scars were compared (12.7 vs. 6.8%, p=0.124). Of flat scars, 93.2% were free of dense adhesions. Pigmented scars had more dense adhesions than non‐pigmented (26.6 vs. 9.3%, p<0.01). Using logistic regression analysis scar length, scar width and appearance of scar (flat or non‐flat) were directly related to adhesion formation. Conclusion. There is an association between scar type and adhesions, particularly for hypertrophic scars and dense adhesions.

Tertiary cytoreduction in the setting of recurrent ovarian cancer (Review)

Ovarian cancer is the most lethal gynecological malignancy, with aggressive surgical debulking and adjuvant chemotherapy as the main treatment modalities. Optimal debulking during the primary surgery is significantly correlated with prolonged survival. As surgical techniques and chemotherapeutic agents improve, more patients with prolonged survival may face secondary and tertiary recurrences. The role of surgical debulking in secondary cytoreduction (SC) is not clearly defined and is based on retrospective series. The treatment of patients with primary or secondary recurrences generally consists of second-line chemotherapy, but may be performed on medically fit patients in certain circumstances. A limited number of studies concerning tertiary cytoreduction (TC) in cases of secondary recurrences have been published. In these studies, conventional prognostic factors for SC, including ascites, an advanced International Federation of Gynecology and Obstetrics (FIGO) stage and/or peritoneal carcinomatosis, did not apply to TC, but the post-operative residual tumor load was significant in determining the prognosis. A limited number of patients with completely-resectable tumors may have an opportunity for a maximal cytoreduction in these circumstances. TC appears to result in a favorable outcome and moderate complication rates. The surgery is an available option for patients with recurrence, in whom a complete tumor resection may be achieved.

Carotid-cavernous fistula in term pregnancy due to spontaneous rupture of carotid-cavernous aneurysm.

Carotid‐cavernous aneurysm accounts for 2–9% of all intracranial aneurysms. The rupture of carotid‐cavernous aneurysm is usually caused by a trauma. Nevertheless, spontaneous rupture may rarely be encountered. Here, we report a term pregnant woman who was diagnosed to have a spontaneous carotid‐cavernous fistula due to carotid‐cavernous aneurysm rupture and was managed with detachable balloon and coils immediately after cesarean section.

Differences in Geographical Distribution and Risk Factors for Urinary Incontinence in Turkey: Analysis of 6,473 Women

Objective: To assess the prevalence, types and risk factors for urinary incontinence (UI) and to evaluate the impact of incontinence on quality of life by using validated and objective questionnaires in the western and eastern parts of Turkey. Methods: In this multicenter observational study, 6,473 women from 38 cities in the western and eastern parts of Turkey were included. UI was assessed by ICIQ-SF (International Consultation on Incontinence Questionnaire Short Form) and IIQ-7 (Incontinence Impact Questionnaire). Results: The UI rate was 20.9% (10% for stress, 8.3% overactive bladder and 2.6% for mixed type). In all, stress incontinence was the most common type. The rate of UI in women residing in the west was higher than in women living in the east (p < 0.001). ICIQ scores were comparable in the two groups but women in the west scored higher in each item of the IIQ. Age >40 years (p < 0.001), number of siblings >5 (p < 0.001) and low educational status (p < 0.001) increased the rate of incontinence. In binary logistic regression analysis menopausal status, age >40 years, number of siblings >5, being overweight, region of residence, and educational status were associated with UI. Conclusion: The rate of UI in women residing in the western part of Turkey was higher than women living in the east. Residing in a different geographical region (in our case living either in the western or eastern part of Turkey) seemed to be an independent risk factor for UI. Moreover, UI deteriorates quality of life and more attention should be paid to this vulnerable population.

Ectopic Pregnancy in a Cesarean Section Scar: Successful Management Using Vacuum Aspiration under Laparoscopic Supervision—Mini Review of Current Literature

A cesarean scar ectopic pregnancy (CSEP) is a fairly uncommon presentation wherein the conceptus is implanted deep in the myometrium and at the exact scar site of the previous cesarean section. There are various CSEP management options that range from medical treatment to surgical interventions such as dilatation and curettage, laparoscopic excision, resection by laparotomy, or, sometimes, a combination of these modalities. Establishing a diagnosis of CSEP can be challenging. Given the relatively rare incidence of CSEP, its management is controversial and current standards of therapy have been derived from data obtained from a limited number of patients. Herein, we present transvaginal ultrasonography (TVUS) imaging findings and management strategies used in a case of CSEP along with the short review of current literature.

Unilateral focal renal artery stenosis complicated by early onset superimposed pre-eclampsia

but also by dose and other variables. Th ey assessed rates of major congenital malformations in 1,402 pregnancies exposed to carbamazepine; 1,280 on lamotrigine; 1,010 on valproic acid and 217 on phenobarbital. An increase in malformation rates with increasing dose was recorded for all drugs and for carbamazepine at doses 400 mg/day. It is well known that Roberts syndrome is a rare autosomal recessive birth defect, characterised by symmetrical limb reduction, craniofacial anomalies (such as bilateral cleft lip and palate, nose and ear anomalies, premaxillary protrusion, hypertelorism, down slanting palpebral fi ssures) facial haemangioma and severe mental and growth retardation (both prenatal and postnatal). Other observed abnormalities include cardiac, renal and gastrointestinal abnormalities. Th is syndrome was fi rst described in 1919 by John Roberts. Our case has some similar malformations to Roberts phocomelia, such as symmetrical limb reduction, facial haemangioma, ear anomalies, high palate, but lack of typical chromosomal abnormality and other malformations excluded this diagnosis (Van Den Berg and Francke 1993). In conclusion, the mother of our patient used high doses of carbamazepine throughout pregnancy, giving rise to concern that high dose carbamazepine exposure antenatally might cause phocomelia. Carbamazepine used in pregnancy should continue to be closely monitored and dosing restricted to the minimum needed to suppress fi ts. Further studies with a large sample size would be needed to explore any association.