Selim Bozkurt

Physiologic outcome of varying speed rotary blood pump support algorithms: a review study.

Rotary blood pumps have the potential to become a viable long-term treatment option for the heart failure patients to bridge to transplantation or destination therapy. However, these devices operate at a constant speed which may lead to long term complications or they may operate in an undesired support mode such as excessive pumping in the patients’ body. A possible solution to such physiological problems or using these devices as a destination therapy or maintaining the optimal support level according to changing conditions in the body is applying a varying speed rotary blood pump support. Over the years, different varying operating speed support algorithms have been proposed to alleviate the effect of the constant speed rotary blood pump support and improve the outcome of these devices. In this paper, it is aimed to compile and present proposed varying speed rotary blood pump support algorithms by classifying them according to the considered physiological problem in each study.

Arterial pulsatility improvement in a feedback-controlled continuous flow left ventricular assist device: an ex-vivo experimental study.

Continuous flow left ventricular assist devices (CF-LVADs) reduce arterial pulsatility, which may cause long-term complications in the cardiovascular system. The aim of this study is to improve the pulsatility by driving a CF-LVAD at a varying speed, synchronous with the cardiac cycle in an ex-vivo experiment. A Micromed DeBakey pump was used as CF-LVAD. The heart was paced at 140 bpm to obtain a constant cardiac cycle for each heartbeat. First, the CF-LVAD was operated at a constant speed. At varying-speed CF-LVAD assistance, the pump was driven such that the same mean pump output was generated. For synchronization purposes, an algorithm was developed to trigger the CF-LVAD each heartbeat. The pump flow rate was selected as the control variable and a reference model was used for regulating the CF-LVAD speed. Continuous and varying-speed CF-LVAD assistance provided the same mean arterial pressure and flow rate, while the index of pulsatility doubled in both arterial pressure and pump flow rate signals under pulsatile pump speed support. This study shows the possibility of improving the pulsatility in CF-LVAD support by regulating pump speed over a cardiac cycle without compromising the overall level of support.

Improving arterial pulsatility by feedback control of a continuous flow left ventricular assist device via in silico modeling

Purpose Continuous flow left ventricular assist devices (CF-LVADs) generally operate at a constant speed, which causes a decrease in pulse pressure and pulsatility in the arteries and allegedly may lead to late complications such as aortic insufficiency and gastrointestinal bleeding. The purpose of this study is to increase the arterial pulse pressure and pulsatility while obtaining more physiological hemodynamic signals, by controlling the CF-LVAD flow rate. Methods A lumped parameter model was used to simulate the cardiovascular system including the heart chambers, heart valves, systemic and pulmonary arteries and veins. A baroreflex model was used to regulate the heart rate and a model of the Micromed DeBakey CF-LVAD (Micromed Technology, Houston, TX, USA) to simulate the pump dynamics at different operating speeds. A model simulating the flow rate through the aortic valve served as reference model. CF-LVAD operating speed was regulated by applying proportional-integral (PI) control to the pump flow rate. For comparison, the CF-LVAD was also operated at a constant speed, equaling the mean CF-LVAD speed as applied in pulsatile mode. Results In different operating modes, at the same mean operating speeds, mean pump output, mean arterial pressure, end-systolic and end-diastolic volume and heart rate were the same over the cardiac cycle. However, the arterial pulse pressure and index of pulsatility increased by 50% in the pulsatile CF-LVAD support mode with respect to constant speed pump support. Conclusions This study shows the possibility of obtaining more physiological pulsatile hemodynamics in the arteries by applying output-driven varying speed control to a CF-LVAD.

Evaluating the Hemodynamical Response of a Cardiovascular System under Support of a Continuous Flow Left Ventricular Assist Device via Numerical Modeling and Simulations

Dilated cardiomyopathy is the most common type of the heart failure which can be characterized by impaired ventricular contractility. Mechanical circulatory support devices were introduced into practice for the heart failure patients to bridge the time between the decision to transplant and the actual transplantation which is not sufficient due to the state of donor organ supply. In this study, the hemodynamic response of a cardiovascular system that includes a dilated cardiomyopathic heart under support of a newly developed continuous flow left ventricular assist device—Heart Turcica Axial—was evaluated employing computer simulations. For the evaluation, a numerical model which describes the pressure-flow rate relations of Heart Turcica Axial, a cardiovascular system model describing the healthy and pathological hemodynamics, and a baroreflex model regulating the heart rate were used. Heart Turcica Axial was operated between 8000 rpm and 11000 rpm speeds with 1000 rpm increments for assessing the pump performance and response of the cardiovascular system. The results also give an insight about the range of the possible operating speeds of Heart Turcica Axial in a clinical application. Based on the findings, operating speed of Heart Turcica Axial should be between 10000 rpm and 11000 rpm.

Enhancement of Arterial Pressure Pulsatility by Controlling Continuous-Flow Left Ventricular Assist Device Flow Rate in Mock Circulatory System

Continuous-flow left ventricular assist devices (CF-LVADs) generally operate at a constant speed, which reduces pulsatility in the arteries and may lead to complications such as functional changes in the vascular system, gastrointestinal bleeding, or both. The purpose of this study is to increase the arterial pulse pressure and pulsatility by controlling the CF-LVAD flow rate. A MicroMed DeBakey pump was used as the CF-LVAD. A model simulating the flow rate through the aortic valve was used as a reference model to drive the pump. A mock circulation containing two synchronized servomotor-operated piston pumps acting as left and right ventricles was used as a circulatory system. Proportional-integral control was used as the control method. First, the CF-LVAD was operated at a constant speed. With pulsatile-speed CF-LVAD assistance, the pump was driven such that the same mean pump output was generated. Continuous and pulsatile-speed CF-LVAD assistance provided the same mean arterial pressure and flow rate, while the index of pulsatility increased significantly for both arterial pressure and pump flow rate signals under pulsatile speed pump support. This study shows the possibility of improving the pulsatility of CF-LVAD support by regulating pump speed over a cardiac cycle without reducing the overall level of support.

An in silico case study of idiopathic dilated cardiomyopathy via a multi-scale model of the cardiovascular system

Mathematical modelling has been used to comprehend the pathology and the assessment of different treatment techniques such as heart failure and left ventricular assist device therapy in the cardiovascular field. In this study, an in-silico model of the heart is developed to understand the effects of idiopathic dilated cardiomyopathy (IDC) as a pathological scenario, with mechanisms described at the cellular, protein and organ levels. This model includes the right and left atria and ventricles, as well as the systemic and pulmonary arteries and veins. First, a multi-scale model of the whole heart is simulated for healthy conditions. Subsequently, the model is modified at its microscopic and macroscopic spatial scale to obtain the characteristics of IDC. The extracellular calcium concentration, the binding affinity of calcium binding proteins and the maximum and minimum elastances have been identified as key parameters across all relevant scales. The modified parameters cause a change in (a) intracellular calcium concentration characterising cellular properties, such as calcium channel currents or the action potential, (b) the proteins being involved in the sliding filament mechanism and the proportion of the attached crossbridges at the protein level, as well as (c) the pressure and volume values at the organ level. This model allows to obtain insight and understanding of the effects of the treatment techniques, from a physiological and biological point of view.

IN-SILICO MODELING OF LEFT VENTRICLE TO SIMULATE DILATED CARDIOMYOPATHY AND CF-LVAD SUPPORT

Numerical modeling of the left ventricle dynamics plays an important role in testing different physiological scenarios and treatment techniques before the in vitro and in vivo assessments. However, utilized left ventricle model becomes vital in the simulations because validity of the results depends on the response of the numerical model to the parameter changes and additional sub-models for the applied treatment techniques. In this study, it is aimed to evaluate different numerical left ventricle models describing healthy and failing ventricle dynamics as well as the response of these models under continuous flow left ventricular assist device support. Six different numerical left ventricle models which include time varying elastance and single fiber contraction approaches are selected and applied in combination with a closed loop electric analogue of the circulation to achieve this purpose. The time varying elastace models relate ventricular pressure and volume changes in a simplistic way while the single fiber contraction models combine different scales ranging from protein to organ level. Change of the hemodynamic signals at the organ level for healthy, failing and CF-LVAD supported left ventricle models shows functionality of these models and helps to understand usability of them for different purposes.

Control strategies for the left ventricular assist devices

In this study numerical models for the cardiovascular system and an axial left ventricular assist device were developed and control studies have been done in the scope of a TUBITAK funded project entitled “Design, analysis, and prototype production of a miniature implantable rotary blood pump.” Diseased cardiovascular system model was obtained by adjusting the parameters of the cardiovascular system model and the rotary blood pump model was integrated to this model. At first the effects of the rotation speed of the pump was considered and then control studies have been done for the pressure difference between outlet and inlet of the pump and the pump flow.