Selma Çivi

The correlation of the total antioxidant status (TAS), total oxidant status (TOS) and paraoxonase activity (PON1) with smoking

OBJECTIVE In this study, we aimed to assess the total antioxidant status (TAS), total oxidant status (TOS) and paraoxonase activity (PON1) in smokers and nonsmokers. DESIGN AND METHODS This cross-sectional analytical study was conducted on 100 smokers and 100 nonsmokers. Low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), total cholesterol (TC), triglyceride (TG), fasting blood glucose (FBG), TAS, TOS and PON1 levels of the participants were determined in the blood samples. TAS and TOS were determined by using the automated measurement method. Paraoxon was used as a substrate for measuring PON1 activity. RESULTS A statistically significant difference could not be found between smokers and nonsmokers in terms of mean FBG, LDL-c, HDL-c, TC, TG, TAS, TOS, PON1, oxidative stress index (OSI) and body mass index (BMI). Mean TAS and TOS levels were higher in men than women (p=0.001). As age (p=0.022) and age to start smoking (p=0.023) increased, TOS level decreased. As the age to start smoking (p=0.001) increased, TAS level decreased whereas as BMI (p=0.001) increased, TAS level also increased. A statistically significant relationship could not be established between age, age to start smoking, duration and amount of smoking, dependence score and BMI and PON1 (p>0.05). CONCLUSIONS In our study, although no significant correlation could be established between smokers and nonsmokers in terms of mean TAS, TOS and PON1, it is a fact that TAS, TOS and PON1 in the organism are affected by many factors and therefore there is a need for more extensive studies in this regard.

Bir Çocuk ve Doğum Hastanesinde Doğan Bebeklerin Özellikleri

Amac: Yenidogan fizyolojik, anatomik ve farmakolojik olarak eriskin bireyden oldukca buyuk farkliliklar gosterir. Hastane bazli bu calismada amacimiz bir cocuk ve dogum hastanesinde dogan bebeklerin ozelliklerini degerlendirmektir. Yontem: Tanimlayici tipteki bu arastirmada, Konya’da Saglik Bakanligina bagli Faruk Sukan Cocuk ve Dogum Hastanesi’nde dogan bebeklerin ozellikleri degerlendirildi. Calismanin evrenini 1-31 Mayis 2007 tarihleri arasinda dogan tum yenidoganlar olusturdu. Ilgili kurumun ve dogum yapan kadinlarin izni alindiktan sonra annelere, dogumdan sonraki ilk gunde gebelik ve dogum ile ilgili bilgileri iceren, onceden hazirlanmis olan ve 42 sorudan olusan bir anket formu uygulandi. Yenidogan bebeklerin cinsiyeti, boy, kilo, bas cevresi, APGAR skoru, dogum sekli, bebeklerin saglik durumu dogum hemsiresi tarafindan standart bir ankete kaydedildi. Bulgular: 956 yenidoganin 494’u (%51.7) erkek, 462’si (%48.3) kiz idi. Annelerin yas ortalamasi 26.6 ± 5.5 (min=16, max=49) olup, evlenme yas ortalamasi 19.9 ± 3.0 yil (min:12, max:37) idi, %71.6’si (n=684) ilkokul egitimi almisti, gebeliklerin 913’u (%95.5) planli olmustu ve %16.3’u esi ile akraba idi. Gebelik sayisi ve yasayan cocuk ortanca degeri 2 idi ve %16.3’unun (n=156) sosyal guvencesi yoktu. Bebeklerin ortalama dogum agirligi 3162 ± 548.38 gr. (min=550, max=4800), ortalama dogum boyu 49.33 ± 2.74cm. (min=20, max=55), ortalama bas cevresi 34.11 ± 2.57cm. (min=12, max=37), APGAR skoru ortalamasi 9.26±1.41, %77.3’u (n=739) vajinal yolla, %22.7’si (n=217) sezaryen ile dogmustu. Bebeklerin 917’si (%95.9) saglikli iken, 39’unda (%4.1) bir patoloji mevcuttu. Saglikli dogmayan bebeklerin 12’si (%1.3) olu dogum, 17’si (%1.8) premature, 7’si (%0.7) mekonyum aspirasyonu, 3’u (%0.3) asfiktik dogmustu. Sonuc: Gebeliklerin planli olmasi, akraba evliliklerinin yuksekligi, erken ve olu doguma bagli bebek olumlerinin az olusu dikkat cekmektedir