Semra Utku
Mersin University
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Publication
Featured researches published by Semra Utku.
European Journal of Medicinal Chemistry | 2009
Mehtap Gökçe; Semra Utku; Esra Küpeli
In this study new 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(p-substituted benzal)hydrazone V derivatives were synthesized as analgesic and anti-inflammatory agents. The structures of compounds were elucidated by spectral and elemental analysis. Compounds Va, Vb and Vc were exhibited more potent analgesic activity than ASA. Also these derivatives demonstrated anti-inflammatory activity as well as standard compound indomethacin. Side effects of the compounds were examined on gastric mucosa. None of the compounds showed gastric ulcerogenic effect compared with reference nonsteroidal anti-inflammatory drugs (NSAIDs). On the basis of available data, the structure-activity relationship of V derivatives was also discussed.
Drug Research | 2011
Semra Utku; Mehtap Gökçe; Ilkay Erdogan Orhan; M. Fethi Şahin
In this study thirteen 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(substituted/nonsubstituted benzal)hydrazone V derivatives were synthesized as acetylcholinesterase and butyrylcholinesterase inhibitors. Ten of the synthesized compounds were synthesized for the first time in this study and the rest of them had been synthesized in a previous study. The structures of compounds V were elucidated by IR, 1H-NMR and MASS spectra. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChe) inhibitory activities of V derivatives were measured using Ellmans method. While some of the 6-substituted-3(2H)-pyridazinone-2-propyl-3-(substituted/-nonsubstituted benzal)hydrazone V derivatives exhibited significant AChE inhibitory activity, none of the compoundsshowed BChE inhibitory activity. Theseresults indicate that V derivatives were AChE inhibitors with AChE/ BChE selectivity.
Journal of Pharmacy and Pharmacology | 2014
Semra Utku; Azime Berna Özçelik; Fatma Gümüş; Şükran Yılmaz; Taibe Arsoy; Leyla Açık; Ayten Çelebi Keskin
The aim of this study was to investigate the in‐vitro cytotoxic activity of new platinum(II) complexes on the human HeLa (ER−), MCF‐7 (ER+) and MDA‐MB 231 (ER−) cell lines. Furthermore, we investigated plasmid DNA interactions and inhibition of BamHI and HindIII restriction enzyme activity of the complex 1–4,7.
Journal of Enzyme Inhibition and Medicinal Chemistry | 2010
Semra Utku; Fatma Gümüş; Seda Tezcan; Mehmet Sami Serin; Aykut Özkul
In this study, two Pt(II) and three Pt(IV) complexes with the structures of [PtL2Cl2] (1), [PtL2I2] (2), [PtL2Cl2(OH)2] (3), [PtL2Cl2(OCOCH3)2] (4), and [PtL2Cl4] (5) (L = benzimidazole as carrier ligand) were synthesized and evaluated for their in vitro antiproliferative activities against the human MCF-7, HeLa, and HEp-2 cancer cell lines. The influence of compounds 1–5 on the tertiary structure of DNA was determined by their ability to modify the electrophoretic mobility of the form I and II bands of pBR322 plasmid DNA. The inhibition of BamH1 restriction enzyme activity of compounds 1–5 was also determined. In general, it was found that compounds 1–5 were less active than cisplatin and carboplatin against MCF-7 and HeLa cell lines (except for 1, which was found to be more active than carboplatin against the MCF-7 cell line). Compounds 1 and 3 were found to be significantly more active than cisplatin and carboplatin against the HEp-2 cell line.
Journal of Enzyme Inhibition and Medicinal Chemistry | 2012
Azime Berna Özçelik; Semra Utku; Fatma Gümüş; Ayten Çelebi Keskin; Leyla Açık; Şükran Yılmaz; Adeviye Özgüngör
In the present study, four Pt(II) complexes with 2-ethyl (1)/or benzyl (2)/or p-chlorobenzyl (3)/or 2-phenoxymethyl (4) benzimidazole carrier ligands were evaluated for their in vitro cytotoxic activities against the human HeLa cervix, oestrogen receptor-positive MCF-7 breast, and oestrogen receptor-negative MDA-MB 231 breast cancer cell lines. The plasmid DNA interactions and inhibition of the BamHI restriction enzyme activities of the complexes were also studied. Complex 3 was found to be more active than carboplatin for all examined cell lines and comparable with cisplatin, except for the HeLa cell line.
Acta Crystallographica Section E-structure Reports Online | 2010
Hakan Arslan; Semra Utku; Kenneth I. Hardcastle; Mehtap Gökçe; Sheri Lense
In the title compound, C13H14ClN5, the piperazine ring adopts a chair conformation and the dihedral angle between the aromatic rings is 13.91 (7)°. The crystal structure is stabilized by weak intermolecular C—H⋯N hydrogen-bond interactions.
Acta Crystallographica Section E-structure Reports Online | 2010
Hakan Arslan; Semra Utku; Kenneth I. Hardcastle; Mehtap Gökçe; Sheri Lense
The title compound, C15H14ClF3N4, was synthesized from 3,6-dichloropyridazine and 1-[3-(trifluoromethyl)phenyl]piperazine. The piperazine ring is flanked by 3-chloropyridazine and 3-trifluoromethylphenyl rings and adopts a chair conformation, whereas the 3-chloropyridazine and 3-trifluoromethylphenyl rings are planar, with maximum deviations of 0.0069 (13) and 0.0133 (14) Å, respectively. The crystal structure is stabilized by weak intermolecular C—H⋯N hydrogen-bond interactions.
European Journal of Medicinal Chemistry | 2005
Mehtap Gökçe; Semra Utku; Sibel Gür; Aykut Özkul; Fatma Gümüş
Turkish Journal of Chemistry | 2010
Semra Utku; Mustafa Topal; Aylin Döğen; Mehmet Sami Serin
Turkish Journal of Chemistry | 2007
Semra Utku; Fatma Gümüş; Sibel Gür; Aykut Özkul