Senay Coskun

Maternal Thyroid Dysfunction and Neonatal Thyroid Problems

Aim. To investigate obstetric features of pregnant women with thyroid disorders and thyroid function tests of their newborn infants. Methods. Women with hypothyroidism and having anti-thyroglobulin (ATG) and anti-thyroid peroxidase (anti-TPO) antibodies were assigned as group I, women with hypothyroidism who did not have autoantibodies were assigned as group II, and women without thyroid problems were assigned as group III. Results. Pregnant women with autoimmune hypothyroidism (group I) had more preterm delivery and their babies needed more frequent neonatal intensive care unit (NICU) admission. In group I, one infant was diagnosed with compensated hypothyroidism and one infant had transient hyperthyrotropinemia. Five infants (23.8%) in group II had thyroid-stimulating hormone (TSH) levels >20 mIU/mL. Only two of them had TSH level >7 mIU/L at the 3rd postnatal week, and all had normal free T4 (FT4). Median maternal TSH level of these five infants with TSH >20 mIU/mL was 6.6 mIU/mL. In group III, six infants (6.5%) had TSH levels above >20 mIU/mL at the 1st postnatal week. Conclusion. Infants of mothers with thyroid problems are more likely to have elevated TSH and higher recall rate on neonatal thyroid screening. Women with thyroid disorders and their newborn infants should be followed closely for both obstetrical problems and for thyroid dysfunction.

PO-0725e Cerebral Tissue Oxygenation At Birth In Term Infants: Comparison Between Early And Late Cord Clamping

Background and aims The aim of our study is to compare the postnatal cerebral tissue oxygenation values in babies with early versus late cord clamping born after elective C/S. Methods In this prospective, observational study, we included term newborns delivered by elective C/S. Babies were segregated into two groups as early (within 15 seconds) and late cord clamping (at 60th seconds). Peripheral arterial oxygen saturation (SpO2) and heart rate were measured using pulse oximetry (Nellcor N200) and regional oxygen saturation of the brain (rSO2 brain) were measured (Invos 5100) between the 3rd and15th minutes and recorded every minute. Fractional tissue oxygen extraction (FTOE) was calculated for each minute (FTOE=pulse oximetry value-rSO2/pulse oximetry value). The measurements were compared for both groups. Results The demographical characteristics, SpO2 levels, heart rates and umbilical cord blood gas values were not significantly different between the groups (p > 0.05). Cerebral oxygenation measurements and FTOE values were significantly higher for each minute in the late cord clamping group (p < 0.05). Bilirubin and hematocrit levels were also statistically higher in this group (p < 0.05) without the need for phototherapy. The increase in rSO2 was faster and the rSO2 plateau was reached earlier in the late cord clamping group (Figure). Conclusions In our study we found that rSO2 brain measurements and FTOE values were higher in the late cord clamping group without the need for any therapy as a result of high bilirubin and hematocrit levels. Abstract PO-0725e Figure 1

1287 Does Cord Seperation Time has an Effect on Omphalitis

Background and Aim There is still controversy regarding the optimal umbilical cord care and the relationship between cord separation and omphalitis. The aim of our study is to investigate the impact of different umbilical cord care practices on the cord seperation time and omphalitis. Methods We included 514 newborns and randomly randomized them into six groups (Group 1: dry care (n:72); groups 2 (n:69), groups 3 (n:69) and 4 (n:76): a single application of 70% alcohol, 4% chlorhexidine or povidon-iodine in the delivery room, groups 5 (n:73) and 6 (n:62): a single application of 70% alcohol or 4% chlorhexidine in the delivery room and continued until discharge) and 421 of them completed the study. Umbilical cord was examined on the 2nd day and between 5–7 days of life for the signs of omphalitis. Babies were followed up for one month and cord seperation time was recorded. Results Cord separation time was the shortest for group one (6.40 ±1.36 day) and the longest for groups 3 and 6 (9.57±3.12 days and 9.58±4.07 days) (p<0.001). Omphalitis was detected in eight patients (1.9%) and there was no significant difference between the groups. There was no relationship between umbilical cord separation time and incidence of umbilical cord infection (p>0.05). Conclusion Our study showed that the mean time of cord separation was significantly shorter (6.40±1.36 days) in the dry cord care group and the longest in both chlorhexidine groups. However, cord seperation time did not have an impact on the rate of omphalitis.