Şenol Emre

The impact of share wave elastography in differentiation of hepatic hemangioma from malignant liver tumors in pediatric population

OBJECTIVE In children it is crucial to differentiate malignant liver tumors from the most common benign tumor, hepatic hemangiomas since the treatment strategies are quite different. We aimed to evaluate the efficiency of shear wave elastography (SWE) technique in differentiation of malignant hepatic tumors and hepatic hemangiomas. METHODS Twenty patients with hepatic tumor were included in our study. Two radiologists performed SWE for 13 patients with malignant hepatic tumors including hepatoblastoma (n=7), hepatocellular carcinoma (n=3), metastasis (n=2), embryonal sarcoma (n=1) and 7 patients with hepatic hemangioma. All of our patients were between the age of 1 and 192 months (mean age: 56.88 months). Receiver operating characteristic analysis was achieved to evaluate the diagnostic accuracy of SWE and to determine the optimal cut-off value in differentiation hepatic hemangioma from malignant hepatic tumors. RESULTS The mean SWE values (in kPa) for the first observer were 46.94 (13.8-145) and 22.38 (6.6-49.6) and those for the second observer were 57.91 (11-237) and 23.87 (6.4-57.5), respectively for malignant hepatic tumors and hepatic hemangiomas. The SWE values of malignant hepatic tumors were significantly higher than those of hepatic hemangioma (p=0.02). The inter-observer agreement was almost perfect (0.81). The area under the receiver operating characteristic curve of SWE for differentiating the hepatic hemangioma from malignant hepatic tumors was 0.77 with a sensitivity of 72.7% and a specificity of 66.7% at a cutoff value of 23.62 with 95% confidence interval. CONCLUSION Shear wave elastography can be helpful in differentiation of malignant hepatic tumors and hepatic hemangioma.

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Antibiyotiklerin sayisi ve kullanim alanlari her gecen gun artmaktadir Antibiyotikler dogru taniyla dogru zamanda dogru kullanim sekli ile ve dogru bir antibiyotik secimi ile kullanilmalidir Antibiyotikler mumkunse kultur gonderildikten sonra baslanmalidir Ampirik antibiyotik kullanimi ciddi ve acil durumlarda tercih edilmelidir Turk Ped Ars 2010; 45: 80 Yil: 50 2 Anahtar sozcukler: Antibiyotik cocuk enfeksiyonAntibiyotiklerin sayisi ve kullanim alanlari her gecen gun artmaktadir Antibiyotikler dogru taniyla dogru zamanda dogru kullanim sekli ile ve dogru bir antibiyotik secimi ile kullanilmalidir Antibiyotikler mumkunse kultur gonderildikten sonra baslanmalidir Ampirik antibiyotik kullanimi ciddi ve acil durumlarda tercih edilmelidir Turk Ped Ars 2010; 45: 80 Yil: 50 2 Anahtar sozcukler: Antibiyotik cocuk enfeksiyonAntibiyotiklerin sayisi ve kullanim alanlari her gecen gun artmaktadir Antibiyotikler dogru taniyla dogru zamanda dogru kullanim sekli ile ve dogru bir antibiyotik secimi ile kullanilmalidir Antibiyotikler mumkunse kultur gonderildikten sonra baslanmalidir Ampirik antibiyotik kullanimi ciddi ve acil durumlarda tercih edilmelidir Turk Ped Ars 2010; 45: 80 Yil: 50 2 Anahtar sozcukler: Antibiyotik cocuk enfeksiyon

Ultrasound-Guided Thoracic Paravertebral Block Experience in a Child

Dear Editor, Postoperative pain treatment is very important in childhood. In addition to classical blocks, paravertebral block is unilaterally or bilaterally used for analgesia during and after thoracal and abdominal surgeries. The paravertebral space contains neural structures, including anterior and posterior branches of the intercostal nerves, the nerves of the sympathetic chain, rami communicantes and Luschka nerves supplying the intervertebral disc. These bare nerve endings are easily affected by local anaesthetics. Paravertebral block is performed with the conventional loss of resistance technique. However, its use in children is limited compared to adults because it is difficult to predict the distance to the pleura and the loss of resistance in children, particularly during thoracic paravertebral block practice. With the use of ultrasonography in peripheral nerve blocks, paravertebral block can now be performed by direct observation through ultrasound. Ultrasound-guided paravertebral block practices have been reported in children (1, 2). We aimed to share our first experience in ultrasound-guided paravertebral block application. A 3.5-year-old girl, who weighed 16 kg and presented with a complaint of cough and who was pre-diagnosed with hereditary right cystic lung disease, was taken to the operating room primarily for bronchoscopy and then, if necessary, for thoracotomy. The patient was premedicated by administering midazolam 1 mg intravenously (iv). Following monitorization, induction was performed with propofol and rocuronium and bronchoscopy was initiated. During the procedure with a rigid bronchoscope, anaesthesia was continued with a sevoflurane/air and remifentanil infusion. Abundant mucopurulent secretion was aspirated because of chronic lung infection. It was decided to perform lobectomy with thoracotomy from the right fourth intercostal space. Bronchoscopy was stopped, and the patient was placed in the left lateral decubitus position. High-frequency linear probe (MyLab5-LA523E, Esaote SpA, Italy) was placed in the paravertebral space in the longitudinal and paramedian position and at the thoracal 7 level, and transverse process, intercostal ligaments, the seashore sign, the pleura and the pleural space were observed (Figure 1). A Stimuplex A 50 mm (B.Braun, Melsungen, Germany) was pushed forward from a lateral to medial direction using the in-plane method and was advanced towards the paravertebral space. While passing through tissues with the needle under the guidance of ultrasound for anatomic coordination, 1 mL 0.9% NaCl was administered twice and the level of the needle tip in the tissues was identified (Figure 2). After entering into the targeted area, aspiration was performed and then the block was performed by administering 0.5 mL kg−1 bupivacaine (0.25%). Meanwhile, the ‘step sign’, which indicates the collapse of the pleura, was observed by expanding the paravertebral space with fluid under ultrasound guidance (Figure 2). During blockade, no blood aspiration was observed and no hypotension occurred. After the beginning of the surgery, remifentanil infusion was discontinued. The anaesthesia of the patient, who was haemodynamically stable for 2.5 h, was maintained with a 2% concentration of sevoflurane (in oxygen/air) and rocuronium. After the operation, the patient was monitored in the recovery room for 1 h following extubation. She experienced pain in her throat due to the rigid bronchoscopy but did not complain of incision pain, and her respiratory depth was adequate. The patient was monitored with the Children’s Hospital of Eastern Ontario Pain Scale (CHEOPS) (4: no pain; 13: very severe) for 24 h. During the 6 h following the moment of blockade, she experienced no pain. It was observed that she was comfortable in the clinic, and she did not have any complications. In the 6th hour, she began to complain of pain, and her pain evaluation score was 7. Therefore, she was administered 15 mg kg−1 paracetamol iv After 1 h, her pain score was evaluated to be 9, and she was administered 20 mg tramadole iv. The same dose was repeated again after 6 h. The CHEOPS pain scores were between 4 and 9 (the score of 9 was observed just once) during 24 h. Figure 1 Before block A: processus transversus, B: pleura, C: intercostal membrane, D: paravertebral space Figure 2 After block A: processus transversus, B:pleura, D: paravertebral space 1,2: 0.9% NaCl was given for control There was no need for additional analgesia during surgery in the space in which many derivations innervated with a single-dose drug, easy extubation and respiration due to adequate analgesia after thoracotomy occur; hence, this plus the maintenance of 6-h analgesia are important gains. If paravertebral block is to be performed, patient comfort can be increased with the routine use of systemic analgesics before the end of analgesia time. In our case, if an opioid had been administered instead of paracetamol at the 6th hour, i.e. when her pain began, and additional paracetamol had been administered every 6 h, better pain scores would have been obtained. In a case report of a 10-year-old child (weight, 40 kg), a lateral spread between the T4–5 and T10–11 levels and parallel to the spine, which covers the longitudinal and intercostal nerves, was observed with 10 mL contrast substance injected into the paravertebral space through a catheter inserted at the level of T10 (3). On the other hand, in a study performed on cadaver babies, a strong relationship was reported between the volume injected as a paravertebral single-dose at the thoracolumbar level and the number of segments with spread. It has been specified that the most appropriate volume to cover the segments between T10 and L1 is 0.2–0.3 mL kg−1 (4). Hence, it was possible to provide analgesia in the thoracal segments with the volume of 0.5 mL kg−1 given from the T7 level in our case. Paravertebral block can be performed through a unilateral or bilateral single dose or catheter. The analgesic action time of single-dose paravertebral block practice is not clearly reported in previous studies. It is reported that the addition of other drugs to a local anaesthetic for prolonging the duration of analgesia obtained by administering a single-dose into the paravertebral space does not provide an advantage (5). It is possible to obtain analgesia for days by providing continuous infusion through the insertion of a catheter. However, because the paravertebral space is too close to the skin in young children (less than 1 cm), the drug administered may leak from the skin and the catheter may easily change place and may be accidentally displaced. Therefore, if it is planned to insert a catheter in young children, these possibilities must be considered. Some complications such as pneumothorax, pleural puncture and vascular injury are possible, but ultrasound guidance reduces these risks. To avoid the side effects of central block in patients who use an anti-coagulant and whose anatomy is not suitable, paravertebral block can be used in the early postoperative period because it provides adequate analgesia. It is an effective analgesia method that can be preferred for providing patient comfort and respiratory rehabilitation provided that a proper combination is established with systematic analgesics. The use of ultrasound makes this block more effective and safer for use in children.

A review of intussusception cases involving failed pneumatic reduction and re-intussusception.

BACKGROUND The aim of the present study was to evaluate cases in which intussusception was unsuccessfully treated with pneumatic reduction (PR), and intussusception recurred following PR. METHODS The medical records of 401 patients who presented with intussusception between 2003 and 2014 were retrospectively analyzed. Included were 61 patients, 20 of whom underwent unsuccessful PR (Group 1), and 41 of whom experienced intussusception recurrence following PR (Group 2). Treatment and outcome were summarized. RESULTS In Group 1 (mean age: 14.2 months; range: 2.5 months-6 years) surgery was indicated due to PR failure in 15 patients, and perforation occurred during PR in 5. In these 5 patients, age was under 1 year (range 6-9 months) and mean time to presentation was 3 days (range 2-4). During laparotomy, pathologies were noted: mesenteric lymphadenopathy (LAP) and/or Peyers patch hyperplasia was observed in 15 cases, Meckels diverticulum in 5 cases. In Group 2 (mean age: 20 months; range: 3 months-6 years), intussusception developed after successful PR in 41 patients, most frequently within the first 24 hours (21.51%). Of the 41 patients, recurrent intussusception (RI) was treated with PR in 36, and laparotomy in 5. Operative findings were mesenteric LAP in 4 and polyp in 1. CONCLUSION PR is effective for the treatment of intussusception and recurrences. Delayed presentation reduces the success rate. In the event of failure, a lead point is usually encountered at laparotomy.

Çocuk yaş grubunda yabancı cisim aspirasyonları

Antibiyotiklerin sayisi ve kullanim alanlari her gecen gun artmaktadir Antibiyotikler dogru taniyla dogru zamanda dogru kullanim sekli ile ve dogru bir antibiyotik secimi ile kullanilmalidir Antibiyotikler mumkunse kultur gonderildikten sonra baslanmalidir Ampirik antibiyotik kullanimi ciddi ve acil durumlarda tercih edilmelidir Turk Ped Ars 2010; 45: 80 Yil: 50 2 Anahtar sozcukler: Antibiyotik cocuk enfeksiyonAntibiyotiklerin sayisi ve kullanim alanlari her gecen gun artmaktadir Antibiyotikler dogru taniyla dogru zamanda dogru kullanim sekli ile ve dogru bir antibiyotik secimi ile kullanilmalidir Antibiyotikler mumkunse kultur gonderildikten sonra baslanmalidir Ampirik antibiyotik kullanimi ciddi ve acil durumlarda tercih edilmelidir Turk Ped Ars 2010; 45: 80 Yil: 50 2 Anahtar sozcukler: Antibiyotik cocuk enfeksiyonAntibiyotiklerin sayisi ve kullanim alanlari her gecen gun artmaktadir Antibiyotikler dogru taniyla dogru zamanda dogru kullanim sekli ile ve dogru bir antibiyotik secimi ile kullanilmalidir Antibiyotikler mumkunse kultur gonderildikten sonra baslanmalidir Ampirik antibiyotik kullanimi ciddi ve acil durumlarda tercih edilmelidir Turk Ped Ars 2010; 45: 80 Yil: 50 2 Anahtar sozcukler: Antibiyotik cocuk enfeksiyon