Senthil Rajan Dharmalingam

Phytochemical, Pharmacological and Toxicological Properties ofFicusdeltoidea:A Review of a Recent Research

Ficusdeltoidea(Mas Cotek) is one of the commonly usedmedicinal plants in Malaysia and it belongs to the family of Moraceae. I t is a shrub that reaches a height of six feet, used as anornamental plant in the tropics or in the home and conservatories.Thisplantis native to Southeast Asia and Philiphines.It has beenused to relieve headache, fever, pneumonia, heart problems, migraines, skin diseases,diarrhea, and toothache. It is also used as an aphrodisiac tonic. Decoction of the whole plant has been used as herbal drink by women after birth to strengthen the uterus and vaginal muscles. It also improves blood circulation and regains body strength as well as treats disorders related to menstrual cycle. This plant is basically a Malay traditional medicine which was very popular ever since it has good medicinal properties.Based on ethnobotanical approaches, F. deltoideahas been claimed to possess antidiabetic, antiulcerogenic, antioxidant, anti -melanogenic, anti-inflammatory,analgesic, antihypertensive properties . Recently, there were a lot of investigations that was carried out to isolate some of the chemical constituents in

Preparing Kaempferol Nanosuspension (KNS) using High Pressure Homogenization (HPH) technique

Background During the last decades, researchers have provided a plethora of therapeutic uses of kaempferol, including anticancer, anti-inflammatory, neuroprotective, anti-oxidative and anti-oestrogenic activities, making kaempferol a valuable compound [1]. However, being a poor water-soluble compound, kaempferol often has insufficient solubility and bioavailability [2].To find a solution for this limitation, this research project mainly focuses on formulating a kaempferol nanosuspension (KNS) using High Pressure Homogenisation (HPH), followed by performing physiological characterization. Kaempferol nanosuspensions are supposed to have a better bioavailability in animal models or even human subjects in future experiments, thereby reducing oral drug dosage required by consumers.

Development of a Validated HPLC Method for the Estimation of Metformin HCl and Propranolol HCl

The present investigation targets to develop a simple, specific, sensitive and accurate reverse phase high performance liquid chromatographic (RP-HPLC) method in human plasma for the estimation of metformin HCl and propranolol HCl from bulk drug and also from the marketed products. Human plasma samples were subjected to correct procedure for protein precipitation by methanol and protein free plasma samples were directly injected into HPLC C18 column. Chromatographic determination was performed on a reversed phase C18 column (3.9 mm X 300 mm, particle size 5 μm) using a mixture of acetonitrile and 0.1M pH 4.5 potassium dihydrogenortho phosphate buffer (mL) (40:60) at a flow rate of 0.8 mL/min and maintained at a pressure of 140 to 150 Kg/cm. The retention time for metformin HCl and propranolol HCl was found to be 9.084 min and 6.132 min respectively at 232 nm without any interference of endogenous compounds in Original Research Article British Journal of Pharmaceutical Research, 4(15): 1909-1922, 2014 1910 the plasma. The method was linear in the range between 50-2000 ng/mL. The peak areas were reproducible as indicated by low coefficient of variation. It was found that the excipients in the tablet dosage form do not interfere in the quantification of active drug by proposed method.

Comparative Quality Control Evaluation of Atenolol Tablets Marketed in Kuala Lumpur, Malaysia

Background: The emergent of many pharmaceutical companies producing their own generic type of drugs after the patent of innovator drugs expired can improve the general healthcare delivery systems as well as de creasing the healthcare costs. But it also raises a few issues with one of it is the widespread of substandard and counterfeit product. Post surveillance study to assess product parameter of various generics drug marketed is

Effects of nanosuspension and inclusion complex techniques on the in vitro protease inhibitory activity of naproxen

Mandevilla coccinea (Hook. et Arn.) Woodson, Apocynaceae is a herb native to South America employed in folk medicine as an analgesic, anti-inflammatory and to inhibit snake venom effects. This work was carried out to study the morpho-anatomical characters of the leaf and stem in order to advance knowledge on this medicinal plant and on pharmacognostic quality control. The plant material was fixed and prepared according to light and scanning electron microtechniques. Its leaves are simple, alternate and ovate-obovate. The epidermis is uniseriate and coated with a thick and striate cuticle. The stomata are paracytic and occur on both foliar surfaces. The dorsiventral-like mesophyll has a sub-epidermal parenchymatic layer containing phenolic substances and is traversed by minor collateral vascular bundles. The midrib is biconvex and the petiole is concave-convex, both presenting bicollateral vascular bundles in an open arc. The stem is circular in transverse section and the epidermis remains in incipient secondary growth. A sub-epidermal parenchymatic layer containing phenolic substances, a discontinuous sclerenchymatic sheath of non-lignified fibres and cylinders of external phloem, xylem and internal phloem occur. Numerous branched laticifers and idioblasts with phenolic substances are present in the leaf and stem.