Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Seon-Pil Jin is active.

Publication


Featured researches published by Seon-Pil Jin.


Dermatology | 2013

RimabotulinumtoxinB versus OnabotulinumtoxinA in the treatment of masseter hypertrophy: a 24-week double-blind randomized split-face study.

Dong-Hun Lee; Seon-Pil Jin; Soyun Cho; Ashley Feneran; Choon Shik Youn; Chong Hyun Won; Gyeong-Hun Park; Byung Wook Kim; Jeesoo An; Sung Eun Chang; Mi Woo Lee

Background: Masseter hypertrophy can be ameliorated by botulinum toxin. Objective: To compare the efficacy and safety of RimabotulinumtoxinB (BTX-B) and OnabotulinumtoxinA (BTX-A) in the treatment of masseter hypertrophy. Methods: Sixteen women with bilateral masseter hypertrophy received single injections of BTX-A or BTX-B at a dose ratio of 1:50 or 1:70 in a 24-week double-blind randomized split-face study. Results: Both BTX-A and BTX-B produced significant improvements in masseter hypertrophy. The maximum volume reduction, as determined by computed tomography scanning, at week 12 was comparable between BTX-A and BTX-B at a dose ratio of 1:70 (15.6 and 14.2%, respectively). At week 24, only masseters treated with BTX-A maintained a significant volume reduction. Investigator ratings and patient satisfaction scores paralleled objective computed tomography measurements. Conclusion: Both BTX-A and BTX-B are effective in the treatment of masseter hypertrophy. BTX-B, at a dose ratio of 1:70, has a comparable efficacy but a shorter duration of action than BTX-A.


Annals of Dermatology | 2010

Analysis of MAST-CLA Results as a Diagnostic Tool in Allergic Skin Diseases

Jung Won Shin; Seon-Pil Jin; Jong Hee Lee; Soyun Cho

BACKGROUND Urticaria and atopic dermatitis are representative allergic skin diseases that can be mediated by IgE. Measuring levels of specific IgE can be used to confirm causative agents of these skin diseases. OBJECTIVE To analyze results from the multiple allergosorbent test chemiluminescent assay (MAST-CLA), which measures specific IgE in the presence of a causative agent/allergen, in IgE-mediated skin diseases. METHODS A total of 404 patients with urticaria, atopic dermatitis or pruritus were enrolled in the present study. Positive rates of specific IgE as well as total serum IgE from the MAST-CLA were compared. RESULTS Positive rates of specific IgE were highest in atopic dermatitis patients, followed by urticaria, and then pruritus, with 57.0%, 37.1%, and 20.8%, respectively (p<0.05). House dust mite species were the most common allergens in both atopic dermatitis and urticaria skin diseases. There were no differences in the overall MAST-CLA results between acute and chronic urticaria. The relative positive rate of inhalant allergen was significantly higher in adult than in child atopic dermatitis patients. CONCLUSION Results from the MAST-CLA showed diversity among the three disease groups, and within each disease group, with different positive rates of specific IgE, a different mean allergen number per patient, and so on. Therefore, we concluded that MAST-CLA could be a useful diagnostic tool for various allergic skin diseases.


Experimental Dermatology | 2016

Serum amyloid A1 secreted from UV‐irradiated keratinocytes induces matrix metalloproteinase‐1 in fibroblasts through toll‐like receptor 4

Sangbum Han; Seon-Pil Jin; Jang-Hee Oh; Eunyoung Seo; Chi-Hyun Park; Hyun-Sun Yoon; Dong Hun Lee; Jin Ho Chung

Ultraviolet (UV) irradiation on skin triggers photoageing‐related phenotypes such as formation of wrinkles. UV ray upregulates matrix metalloproteinase‐1 (MMP‐1), which in turn degrades extracellular matrix proteins, mostly collagens. Serum amyloid A1 (SAA1) is an acute‐phase protein of which plasma concentration increases in response to inflammation. Although the expression of SAA1 in the skin was reported, its function in the skin is yet to be studied. In this research, we found that the expression of SAA1 was increased in acute UV‐irradiated buttock skin and photoaged forearm skin in vivo. UV irradiation also increased SAA1 in normal human epidermal keratinocytes (NHEK), and treatment of recombinant human SAA1 (rhSAA1) induced MMP‐1 in normal human dermal fibroblasts (NHDF) but not in NHEK. Next, we demonstrated that NHDF treated with UV‐irradiated keratinocyte‐conditioned media showed the increased MMP‐1 expression; however, this increase of MMP‐1 in NHDF was inhibited by knockdown of SAA1 in NHEK. In addition, knockdown of Toll‐like receptor 4 (TLR4) inhibited rhSAA1‐induced MMP‐1 expression in NHDF. Taken together, our data showed that UV‐induced SAA1 production in NHEK, and this secreted SAA1 induced MMP‐1 expression in NHDF in a paracrine manner through TLR4 signalling pathway. Therefore, our results suggest that SAA1 can be a potential mediator for UV‐induced MMP‐1 expression in human skin.


Journal of Dermatological Science | 2018

Urban particulate matter in air pollution penetrates into the barrier-disrupted skin and produces ROS-dependent cutaneous inflammatory response in vivo

Seon-Pil Jin; Zhenyu Li; Eun Kyung Choi; Serah Lee; Yoen Kyung Kim; Eun Young Seo; Jin Ho Chung; Soyun Cho

BACKGROUND Particulate matter (PM) is an integral part of air pollution, which is a mixture of particles suspended in the air. Recently, it has been reported that PM is associated with increased risks of skin diseases, especially atopic dermatitis in children. However, it is unclear if PM directly goes into the skin and what mechanisms are involved in response to PM. OBJECTIVE To see whether PM could penetrate into the barrier-disrupted skin, produce reactive oxygen species (ROS), and elicit an inflammatory response. METHODS We collected PMs during a winter in Seoul and used cultured keratinocytes for in vitro study and tape-stripped BALB/c mice for in vivo study. RESULTS Keratinocyte cytotoxicity increased in a dose-dependent manner by PM treatment. IL-8 and MMP-1 mRNA expression and protein levels were significantly increased compared to control by qPCR and ELISA, respectively. Cellular ROS production was increased by PM treatment, and antioxidant N-acetyl cysteine pretreatment prevented induction of inflammatory cytokines IL-8 and MMP-1. In PM-treated keratinocytes, electron-dense subcellular particles were observed by transmission electron microscopy. PM was observed inside hair follicles in both intact and barrier-disrupted skin in vivo. Additionally, intercellular penetration of PM was seen in the barrier-disrupted skin. Repeated PM application induced epidermal thickening and dermal inflammation with neutrophil infiltration. Finally, N-acetyl cysteine could ameliorate skin inflammation induced by PM application. CONCLUSION PM penetrates into the barrier-disrupted skin, causing inflammation, demonstrating detrimental effects in the skin.


Experimental Dermatology | 2018

Imiquimod-applied Interleukin-10 deficient mice better reflects severe and persistent psoriasis with systemic inflammatory state

Seon-Pil Jin; Seong-Joon Koh; Da-Ae Yu; Min-Woo Kim; Hee Tae Yun; Dong Hun Lee; Hyun-Sun Yoon; Soyun Cho; Hyun-sun Park

Previous studies have shown that imiquimod‐induced psoriasis‐like skin inflammation in mice resembles phenotypic changes and cytokine profiles of human psoriasis. However, a psoriasis animal model reflecting the chronic inflammatory course and comorbidities has not yet been established. We aimed to evaluate the imiquimod‐applied interleukin (IL)‐10 deficient mouse model in comparison with previous models. IL‐10 deficient and wild‐type (WT) mice received either imiquimod or vehicle cream for 12 days and were sacrificed on day 15. For earlier time point data, either imiquimod or vehicle cream was applied for 2 days, and the mice were sacrificed on day 3. Imiquimod‐applied IL‐10 deficient mice showed more persistent psoriasis‐like inflammation and higher severity index than did WT between day 8 and 15. Histopathologically, they demonstrated significantly thicker epidermis and larger number of CD45+, myeloperoxidase+ and IL‐17+ cell counts on day 15. Quantitative reverse transcription‐polymerase chain reaction with skin tissue revealed significantly higher imiquimod‐induced IL‐23p19 expression in imiquimod‐applied IL‐10 deficient mice on day 15. IL‐10 deficient mice also showed significantly higher serum levels of imiquimod‐induced IL‐17A and tumor necrosis factor‐α by enzyme‐linked immunosorbent assay on day 15. Furthermore, IL‐10 deficient mice showed more prominent increase of spleen weight and decrease of body weight in response to imiquimod application on day 3 and 15. In conclusion, IL‐10 deficient mice model with imiquimod application may better reflect severe and persistent psoriasis with systemic inflammatory state.


Journal of Investigative Dermatology | 2017

UCHL1 Regulates Melanogenesis through Controlling MITF Stability in Human Melanocytes

Eun Young Seo; Seon-Pil Jin; Kyung-Cheol Sohn; Chi-Hyun Park; Dong Hun Lee; Jin Ho Chung

Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is involved in many signaling pathways via the ubiquitin-proteasome system. UCHL1 is expressed in the human skin and serves as a neuronal marker; however, its functions in melanogenesis remain unknown. Here, we investigated the role of UCHL1 in melanogenesis and elucidated the underlying mechanism using human melanocytes. UCHL1 downregulation by small interfering RNA resulted in upregulation of microphthalmia-associated transcription factor (MITF), tyrosinase, dopachrome tautomerase, tyrosinase-related protein-1, and melanin. In contrast, overexpression of UCHL1 in melanocytes via adenovirus transfection led to downregulation of tyrosinase, dopachrome tautomerase, and tyrosinase-related protein-1 and decreased melanin contents. Furthermore, UCHL1 reduced the protein, but not mRNA, levels of MITF, the upstream regulator of tyrosinase, dopachrome tautomerase, and tyrosinase-related protein-1. Inhibition of de novo protein synthesis and treatment of normal human primary epidermal melanocytes with proteasome inhibitor MG132 revealed that UCHL1 negatively regulates the stability of MITF by binding to the ubiquitinated protein. Finally, overexpression of MITF via an adenovirus restored the level of melanogenesis reduced by UCHL1. Collectively, our findings indicate a role of UCHL1 in regulating skin pigmentation. Suppression of MITF activity by UCHL1 via protein degradation might aid in the development of new therapeutic approaches for melanoma or dyspigmentation disorders.


Annals of Dermatology | 2014

Tinea incognito simulating herpes simplex virus infection.

Young Woon Park; Jae Woo Choi; Seung Hwan Paik; Dong-Young Kim; Seon-Pil Jin; Hyun Sun Park; Hyun-Sun Yoon; Soyun Cho

Dear Editor: A 30-year-old-man presented with a 2-month history of a facial lesion. He was examined by general practitioners, and the eruption was diagnosed as eczema. Topical corticosteroid was applied for 1 month, and the eruption initially seemed to improve with this treatment; but later on, it persisted, and gradually extended in size. Dermatological examination revealed the presence of grouped erythematous papules, vesicles and crusts on erythematous bases, on the right lower eyelid (Fig. 1A). He had no medical history, and no family member who had had similar skin eruptions or symptoms. The initial clinical differential diagnosis included herpes simplex, herpes zoster, and allergic contact dermatitis, caused by an antibiotic eye drop. We prescribed oral and topical acyclovir, and performed a skin biopsy, to reveal the exact diagnosis. Skin lesions did not respond to 5 days of acyclovir therapy, and histologic examination showed infiltration of various inflammatory cells from the upper to lower dermis, parakeratosis, irregular acanthosis, intraepidermal exocytosis of neutrophils, and extravasation of erythrocytes (Fig. 2A, B). Fungal hyphae and spores in the stratum corneum were identified on the periodic acid Schiff stained section (Fig. 2C). These findings led to the diagnosis of superficial fungal infection that had lost its typical clinical appearance, because of the use of steroids. The cause of infection might be dermatophytes, but non-dermatophytic fungi could be possible. Afterwards, the history that he had had contact with his cat was verified. He was administered oral terbinafine 250 mg daily, and topical terbinafine cream. After 8 weeks, the number of papules decreased, and the inflammatory reaction improved (Fig. 1B). Treatment was continued a month longer, and the facial eruption finally cleared (Fig. 1C). Fig. 1 (A) On the lateral side of the right lower eyelid, grouped erythematous papules, vesicles and crusts on erythematous bases. (B) At 8 weeks of treatment with antifungal agents, facial eruptions improved, but some papules and vesicles on mild erythema persisted. ... Fig. 2 Infiltration of various inflammatory cells from the upper to lower dermis, parakeratosis, irregular acanthosis, intraepidermal exocytosis of neutrophils, and extravasation of erythrocytes in H&E stain (A: ×40, B: ×400), fungal ... The clinical features of tinea faciei are characterized by various morphology, and because of that, the entity can mimic many other cutaneous disorders1. Moreover, because tinea faciei is relatively uncommon when compared with other forms of superficial fungal infection, it is often misdiagnosed; and treated with glucocorticosteroids, not antifungal agents1. Imprecise use of topical or oral corticosteroids in tinea faciei can modify their clinical features, and make the correct diagnosis more difficult2; therefore, tinea faciei is one of the considerable examples of tinea incognito1. One retrospective study showed 35.7% cases of tinea incognito among tinea faciei, because of improper diagnosis, and inappropriate therapy3. Other authors revealed that 50% to 70% of patients with tinea faciei are initially misdiagnosed as having other dermatoses2. The pathomechanism of tinea incognito is thought to be closely associated with a steroid-modified response of the host to cutaneous fungal infection4. Topical corticosteroids allow fungi to grow readily, and alter the clinical feature of the lesions, because they have immunosuppressive activity5. Regretfully, glucocorticosteroids are extensively used by patients and non-dermatologists, and lead to long-lasting fungal infections1, similar to that which occurred in our case. Atypical presentations of tinea faciei can lead to misdiagnosis. The present case underlines that physicians should keep in mind that clinical features of superficial fungal infection can be substantially modified by incorrect treatment, to mimic even herpes simplex virus infection. Fungal infection should be on the list of differential diagnoses of facial eruptions, especially in cases not responding to preceding management.


Annals of Dermatology | 2018

Deeper Wrinkle Formation and Less Melanin Production in Aged Korean Women with B Blood Type

Jang-Hee Oh; Inn-Gyung Oh; Chi-Hyun Park; Min Kyeong Shin; Serah Lee; Dong Hun Lee; Mira Choi; Seon-Pil Jin; Hyun-Sun Yoon; Soyun Cho; Jin Ho Chung

364 Ann Dermatol Received October 17, 2016, Revised April 13, 2017, Accepted for publication June 5, 2017 Corresponding author: Jin Ho Chung, Department of Dermatology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea. Tel: 82-2-2072-2414, Fax: 82-2-742-7344, E-mail: [email protected] ORCID: https://orcid.org/0000-0003-0520-0266 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright


Journal of Dermatological Science | 2015

Beneficial effects of blood group antigen synthesis-increasing natural plant extracts and monosaccharides on extracellular matrix protein production in vivo

Mira Choi; Jang-Hee Oh; Min Kyeong Shin; Serah Lee; Dong Hun Lee; Seon-Pil Jin; Soyun Cho; Jin Ho Chung

Skin aging is clinically characterized by the wrinkle formation associated with damage of dermal extracellular matrix (ECM) [1]. Recent study has indicated that expression of ABO blood group antigens (ABH antigens) are reduced in the sun exposed skin, suggesting that ABH antigens may be implicated in photoaging process [2]. Hence, the present study was aimed to investigate the possible anti-aging potential of ABH antigen synthesis-increasing materials on ECM protein production in human skin, which are mixtures of natural plant extracts (Camellia sinensis (Green tea) leaf extract, Polygonum cuspidatum root extract; Biospectrum, Seongnam, Republic of Korea; Ginkgo biloba leaf extract, Cynara scolymus (Artichoke) leaf extract, Selaginella tamariscina extract; kindly gifted from Amorepacific R&D Institute, Yongin, Republic of Korea) and ABH antigen-composing monosaccharides (D-Glucose, D-Galactose, L-fucose, N-acetyl-D-glucosamine, N-acetyl-D-galactosamine; Sigma–Aldrich, St. Louis, MO), increasing ABH antigen expression in HaCaT cells and human skin (Suppl. Figs. S1 and S2), by immunohistochemical determination of ECM proteins. Firstly, we performed one-time topical application of the minimally-effective vehicle cream solution (gifted from Amorepacific R&D Institute), composition TYPE I, containing five kinds of natural plant extracts (1%, C. sinensis (Green tea) leaf extract; 3%, all other extracts, respectively) in the vehicle cream, and composition TYPE II, containing five kinds of monosaccharides (1%, respectively) in the vehicle cream, to the healthy female human buttock skin (age range; 44–57 yr, mean age standard error (SE); 49.2 5.0 yr, n = 6). At 48 h after application, 2 mm punch biopsy was performed, and their frozen sections were analyzed by immunohistochemistry. This study was approved by the institutional review board of


Dermatology | 2012

Foxp3+ Regulatory T Cells Are Increased in the Early Stages of Halo Nevi: Clinicopathological Features of 30 Halo Nevi

H.S. Park; Seon-Pil Jin; Y.-D. Choi; M.-H. Shin; S.E. Lee; Sook Jung Yun

Background: There have been few clinical studies of the role of regulatory T cells (Tregs) in halo formation of halo nevus. Objective: To evaluate the clinicopathologic features and the presence of Tregs in halo nevi. Methods: We analyzed 30 halo nevi and performed immunohistochemical analysis using antibodies against CD4, CD8, CD25 and Foxp3. We also performed double immunohistochemical staining for Foxp3 and CD25. Results: We found significant increases in Foxp3+ Tregs, and the shorter the halo nevus duration, the more Foxp3+ Tregs were detected. Also, the ratio of Foxp3 to CD8 T cells was increased in early stages of halo nevi. Double immunohistochemical staining suggested that the Tregs in the halo nevi were CD25+Foxp3+ T cells. Conclusions: Foxp3+ Tregs were greatly increased in the halo nevi. The shorter the halo nevi duration, the more Foxp3+ Tregs were involved in the earlier developmental stages of halo nevi.

Collaboration


Dive into the Seon-Pil Jin's collaboration.

Top Co-Authors

Avatar

Jin Ho Chung

Seoul National University

View shared research outputs
Top Co-Authors

Avatar

Dong Hun Lee

Seoul National University

View shared research outputs
Top Co-Authors

Avatar

Soyun Cho

Seoul National University

View shared research outputs
Top Co-Authors

Avatar

Eun Young Seo

Seoul National University

View shared research outputs
Top Co-Authors

Avatar

Hyun-Sun Yoon

Seoul National University

View shared research outputs
Top Co-Authors

Avatar

Jang-Hee Oh

Seoul National University

View shared research outputs
Top Co-Authors

Avatar

Chi-Hyun Park

Seoul National University

View shared research outputs
Top Co-Authors

Avatar

Sangbum Han

Seoul National University

View shared research outputs
Top Co-Authors

Avatar

Serah Lee

Seoul National University

View shared research outputs
Top Co-Authors

Avatar

Yeon Kyung Kim

Seoul National University

View shared research outputs
Researchain Logo
Decentralizing Knowledge