Seong Hee Jang

Dose-independent pharmacokinetics of recombinant human interferon-αA in rabbits

The pharmacokinetic parameters of rHuIFN-α A, such as t12(53.7–85.3 min), MRT (29.5–42.4 min), Vss (107–163 ml kg−1) and CL (3.65–4.69 ml min−1 kg−1) were found to be dose-independent after intravenous administration to rabbits using a 1000-fold range of doses, i.e., 106–109 U kg−1. The extent of bioavailability was essentially complete when interferon at 107 U kg−1 was administered subcutaneously to rabbits. Radioactivity was highly concentrated in the kidney and plasma, and less concentrated in the other tissues or organs studied at 2 h after subcutaneous administration of the radiolabelled interferon, 125I-rHuIFN-α A (100000 cpm kg−1) to rabbits.

Pharmacokinetics of ciprofloxacin after intravenous administration of ciprofloxacin-TOF in rabbits

Abstract The pharmacokinetic parameters and tissue distribution of ciprofloxacin were compared after intravenous (i.v.) administration of ciprofloxacin-HCl or ciprofloxacin-TOF salts, 30 mg kg −1 as free ciprofloxacin to rabbits. The pharmacokinetic parameters and tissue distribution of ciprofloxacin were not significantly different between i.v. administration of ciprofloxacin-TOF and ciprofloxacin-HCl salts, indicating that ciprofloxacin-TOF salt is pharmacokinetically equivalent to ciprofloxacin-HCl salt. Radioactivity was evenly distributed in all the tissues (or organs) studied at 48 h after i.v. administration of 1- 14 C- or 1,2,3,4,5- 14 C-labelled TOF, 750000 dpm kg −1 to rabbits and the mean percentages of i.v. dose excreted in 48 h urine as measured radioactivity were 23.6 and 26.1% for [1- 14 C]- and [1,2,3,4,5- 14 C]TOF, respectively.