Seong-Kyung Cho

THE ASSOCIATION OF URINARY NAPHTHOL LEVEL AND STRUCTURAL CHANGE OF THE BRAIN-BRAIN CORTICAL THINNING AND VENTRICULAR ENLARGEMENT: A CROSS-SECTIONAL STUDY

baseline MCI and over two years of follow-up (N1⁄4601), we selected all who reverted to NC at least once, and having additional follow-up after reversion. Groups were compared using parametric and nonparametric tests where appropriate, on clinical (age, education, gender, APOE genotype, GDS), cognitive (MMSE, RAVLT total recall) and imaging markers (PET amyloid, PET FDG, hippocampal volume, MRI white matter hyperintensities). We evaluated biomarker abnormality proportions, using Chi-square tests. Results: Of the 65 (11% from the total MCI sample) individuals with MCI who reverted to NC, 53 (82%) had additional follow-up available. At last diagnosis, 37 (70%) subjects remained cognitively normal, while 13 (24%) had converted to MCI, and 3 (6%) to dementia. Compared to those with persistent normal cognition at follow-up, those who declined were older (mean1⁄47368 years vs 6867 years; p1⁄40.04), had higher amyloid burden (mean SUVR 1.2460.21 vs 1.0960.15; p1⁄40.01), and tended to have less years of education, lower glucose metabolism and smaller hippocampal volume (table 1). Conclusions: The MCI reversion rate to normal cognition was comparable to memory clinic studies. The majority of MCI reverters remained cognitively normal. Those who progressed to MCI or dementia were older age and had more abnormal AD biomarkers. MCI reverters without any signals of neurodegeneration may not be at increased risk for dementia. These results imply that biomarkers may aid in the prognosis of reverting MCI. References: 1. Aerts et al. 2017. Neurology; 2. Canevelli et al. 2016. JAMDA.

AMBIENT AIR POLLUTION ASSOCIATED WITH BRAIN CORTICAL THINNING: A CROSS-SECTIONAL STUDY IN A COMMUNITY-BASED COHORT

P2-595 AMBIENTAIR POLLUTION ASSOCIATED WITH BRAIN CORTICALTHINNING: A CROSS-SECTIONAL STUDY IN A COMMUNITY-BASED COHORT Jaelim Cho, Jungwoo Sohn, Juhwan Noh, Seong-Kyung Cho, Jee Eun Choi, Hyunmee Kim, Woojin Kim, Heeseon Jang, Changsoo Kim, University of Auckland, Auckland, New Zealand; Institute of Human Complexity and Systems Science, Yonsei University, Incheon, South Korea; Yonsei University College of Medicine, Seoul, South Korea. Contact e-mail: chojael@gmail.com

EFFECT MODIFICATIONS OF THE ASSOCIATION BETWEEN SERUM MERCURY LEVEL AND MILD COGNITIVE IMPAIRMENT BY SMOKING STATUS

P3-540 EFFECT MODIFICATIONS OF THE ASSOCIATION BETWEEN SERUM MERCURY LEVEL AND MILD COGNITIVE IMPAIRMENT BY SMOKING STATUS Juhwan Noh, Jaelim Cho, Seong-Kyung Cho, Jee Eun Choi, Eunju Lee, Changsoo Kim, Yonsei University College ofMedicine, Seoul, Republic of South Korea; Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom. Contact e-mail: njuhwan@yuhs.ac

Association between Perceived Stress and Asthma Symptoms in Adolescents

Background: Although the effect of psychological stress on asthma has long been suggested, there is little evidence regarding asthma symptoms such as wheezing in relation to perceived stress in adolescents.

Ambient air pollution and emergency department visits for stroke

WCN 2013 No: 806 Topic: 3 — Stroke Isolated infarction of medullary pyramid: Its clinical features and pathology S. Kaji, H. Katada, S. Sato, H. Shibayama, T. Fukutake, Y. Kikuchi, S. Murayama. Neurology, Kameda Medical Center, Kamogawa, Japan; Radiology, Kameda Medical Center, Kamogawa, Japan; Neuropathology, Tokyo Metropolitan Institute of Gerontology,

Association between obstructive pulmonary function abnormalities and brain cortical thickness

WCN 2013 No: 1860 Topic: 36 — Other Topic A fast method for determination of the parameters of pulsed-CEST MRI G. Xiao, Z. Dai, P.Z. Sun, R. Wu. Department of Mathematics and Applied Mathematics, Hanshan Normal University, Chaozhou, China; Department of Radiology, 2nd Affiliated Hospital of Shantou University Medical College, Shantou, China; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA Objective: The object of the research is to demonstrate a fast method for simultaneous determination of labile proton fraction ratio and exchange rate and other parameters of pulsed chemical exchange saturation transfer (pulsed-CEST) MRI. Methods: Mathematical models have been developed to describe pulsed-CEST contrast. We simulated pulsed-CEST MRI in MatLab (MathWorks, Natick, MA) for Z-spectra and asymmetry spectra using matrix exponential algorithm. The number of repetition of the sequence is 256. Each Gaussian-shaped pulse was divided into 101 steps, and the evolution within each step was modeled assuming a constant amplitude. We also calculated the above spectra by using the fourth/fifth-order RKF(ode45 in MatLab; MathWorks, Natick, MA, USA) with an absolute error tolerance for each integration step of 10−6, and compared with the results obtained by our method. Calculations were performed using MatLab on Pentium® Dual-Core CPU (2.2 GHz) with 2-GB RAM. There was a good agreement between them, and this method was much faster than the RKF method (by a factor of approximately 1000 in this study). We simulated that the error of the labile proton fraction ratio, exchange rate and other parameters less than 5%. Results: This method will be useful for determination of labile proton fraction ratio and exchange rate and other parameters, and for analyzing the pulsed-CEST contrast mechanism and/or investigating the optimal RF pulse parameters such as the RF pulse duration or pulse flip angle. doi:10.1016/j.jns.2013.07.2242 Abstract — WCN 2013 No: 1859 Topic: 36 — Other Topic Association between obstructive pulmonary function abnormalities and brain cortical thickness WCN 2013 No: 1859 Topic: 36 — Other Topic Association between obstructive pulmonary function abnormalities and brain cortical thickness J. Cho, J. Sohn, S.-K. Cho, H. Kim, C. Kim, D.-C. Shin, S. Seo. Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,