Serge Lamothe

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions.

In our continuing effort to discover and develop apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, we explored the structure-activity relationship (SAR) of alkyl substituted pyrrole fused at the 7,8-positions. A methyl group substituted at the nitrogen in the 7-position of the pyrrole ring led to a series of potent apoptosis inducers with potency in the low nanomolar range. These compounds were also found to be low nanomolar or subnanomolar inhibitors of cell growth, and they inhibited tubulin polymerization, indicating that methylation of the 7-position nitrogen does not change the mechanism of action of these chromenes. Compound 2d was identified as a highly potent apoptosis inducer with an EC50 value of 2 nM and a highly potent inhibitor of cell growth with a GI50 value of 0.3 nM in T47D cells.

Enantioselective total synthesis of salicylihalamides A and B

Abstract We have devised a total synthesis of (12 R ,13 S ,15 R ) salicylihalamides A and B, which allowed revision of the absolute stereochemistry of the natural compounds. The same strategy was then applied to the preparation of naturally occurring salicylihalamides.

Transannular Diels-Alder reaction of 14-membered macrocyclic trienes. Part I: Theoretical analysis and stereochemical predictions

Abstract Theoretical analysis and stereochemical predictions on the transannular Diels-Alder reaction of the 8 isomeric macrocyclic trienes 1 are reported.

Transannular Diels-Alder reaction of 14-membered macrocyclic trienes. Part II: Experimental results and synthetic potential

The synthesis and the transannular Diels-Alder reactivity of the 8 isomeric 14-membered macrocyclic trienes 2 are reported.