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Dive into the research topics where Sergio Shiguemi Furuie is active.

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Featured researches published by Sergio Shiguemi Furuie.


Psychiatry Research-neuroimaging | 2000

A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive–compulsive disorder using single photon emission computed tomography (SPECT)

Geraldo F. Busatto; Denis Roberto Zamignani; Carlos Alberto Buchpiguel; Griselda J. Garrido; Michael F. Glabus; Euclides Timóteo da Rocha; Alex F. Maia; Maria C. Rosario-Campos; Cláudio Campi de Castro; Sergio Shiguemi Furuie; Marco Antonio Gutierrez; Philip McGuire; Euripedes C. Miguel

Several functional imaging studies have reported abnormalities of the orbitofrontal and anterior cingulate cortices, striatum and thalamus in obsessive-compulsive disorder (OCD). These studies have often been limited by small patient samples and image analysis methods that rely on region-of-interest (ROI) approaches. We have assessed resting regional cerebral blood flow with 99mTc-ECD SPECT in 26 unmedicated OCD patients and 22 healthy control subjects using the voxel-based Statistical Parametric Mapping method for data analysis. We found a significantly reduced ECD uptake in OCD patients relative to the control subjects in the right lateral orbitofrontal cortex, and in the left dorsal anterior cingulate cortex (P<0.001 two-tailed, uncorrected for multiple comparisons). There were significant positive correlations in the OCD group between the ECD uptake in the left lateral orbitofrontal cortex and ratings for obsessive-compulsive symptoms (OCS), and between the ECD uptake in the right medial orbitofrontal cortex and the ratings for both OCS and depressive symptoms. There were also unpredicted significant ECD uptake increases in the cerebellum in OCD patients, as well as a negative correlation between posterior cingulate ECD uptake and OCS severity (P<0.05, corrected for multiple testing). These results implicate specific subregions of the orbitofrontal and anterior cingulate cortices in the pathophysiology of OCD, as well as suggesting the involvement of other areas not usually included in ROI-based imaging studies. With the incorporation of voxel-based methods and the use of large patient samples, rCBF-SPECT studies may continue to provide valuable information about the functional anatomy of OCD.


Journal of Neurology, Neurosurgery, and Psychiatry | 2002

Relation between medial temporal atrophy and functional brain activity during memory processing in Alzheimer’s disease: a combined MRI and SPECT study

Griselda J. Garrido; Sergio Shiguemi Furuie; Carlos Alberto Buchpiguel; Cássio M.C. Bottino; Osvaldo P. Almeida; Carla G. Cid; Cândida H. P. Camargo; Cláudio Campi de Castro; M F Glabus; Geraldo F. Busatto

Objective: To investigate the relation between atrophy of the hippocampal region and brain functional patterns during episodic memory processing in Alzheimer’s disease. Patients and methods: Whole brain structural magnetic resonance imaging (MRI) data and single photon emission computed tomography (SPECT) measures of regional cerebral blood flow (rCBF) were obtained during a verbal recognition memory task in nine subjects with mild Alzheimer’s disease and 10 elderly healthy controls. Using the statistical parametric mapping approach, voxel based comparisons were made on the MRI data to identify clusters of significantly reduced grey matter concentrations in the hippocampal region in the Alzheimer patients relative to the controls. The mean grey matter density in the voxel cluster of greatest hippocampal atrophy was extracted for each Alzheimer subject. This measure was used to investigate, on a voxel by voxel basis, the presence of significant correlations between the degree of hippocampal atrophy and the rCBF SPECT measures obtained during the memory task. Results: Direct correlations were detected between the hippocampal grey matter density and rCBF values in voxel clusters located bilaterally in the temporal neocortex, in the left medial temporal region, and in the left posterior cingulate cortex during the memory task in the Alzheimer’s disease group (p < 0.001). Conversely, measures of hippocampal atrophy were negatively correlated with rCBF values in voxel clusters located in the frontal lobes, involving the right and left inferior frontal gyri and the insula (p < 0.001). Conclusions: Hippocampal atrophic changes in Alzheimer’s disease are associated with reduced functional activity in limbic and associative temporal regions during episodic memory processing, but with increased activity in frontal areas, possibly on a compensatory basis.


computing in cardiology conference | 2002

Automatic measurement of carotid diameter and wall thickness in ultrasound images

Marco Antonio Gutierrez; Paulo Eduardo Pilon; Silvia G. Lage; Liliane Kopel; Ricardo T Carvalho; Sergio Shiguemi Furuie

Carotid vessel ultrasound imaging is a reliable noninvasive technique to measure the arterial morphology. Lumen Diameter (LD), intima-media thickness (IMT) of the far wall, and plaque presence can be reliably determined using B-mode ultrasound. In order to measure the carotid IMT as well as any other more complex quantitative indices of vessel morphology, it is necessary to identify lumen-intima and media-adventitia borders in the ultrasound images. In this paper we describe an automatic approach to measure LD and IMT based on an active contour technique improved by a multiresolution analysis. The measurements of LD and IMT were compared to manual tracing of the vessels border in terms of coefficients of variability (CV) and correlation (R). The results have shown that the method is a reliable and reproducible way of assessing the LD and far wall IMT in the carotid artery.


international conference of the ieee engineering in medicine and biology society | 2009

Providing Integrity and Authenticity in DICOM Images: A Novel Approach

Luiz Octavio Massato Kobayashi; Sergio Shiguemi Furuie; Paulo S. L. M. Barreto

The increasing adoption of information systems in healthcare has led to a scenario where patient information security is more and more being regarded as a critical issue. Allowing patient information to be in jeopardy may lead to irreparable damage, physically, morally, and socially to the patient, potentially shaking the credibility of the healthcare institution. Medical images play a crucial role in such context, given their importance in diagnosis, treatment, and research. Therefore, it is vital to take measures in order to prevent tampering and determine their provenance. This demands adoption of security mechanisms to assure information integrity and authenticity. There are a number of works done in this field, based on two major approaches: use of metadata and use of watermarking. However, there still are limitations for both approaches that must be properly addressed. This paper presents a new method using cryptographic means to improve trustworthiness of medical images, providing a stronger link between the image and the information on its integrity and authenticity, without compromising image quality to the end user. Use of Digital Imaging and Communications in Medicine structures is also an advantage for ease of development and deployment.


Ultrasound in Medicine and Biology | 2011

Automatic Coronary Wall Segmentation in Intravascular Ultrasound Images Using Binary Morphological Reconstruction

Matheus Cardoso Moraes; Sergio Shiguemi Furuie

Intravascular ultrasound (IVUS) image segmentation can provide more detailed vessel and plaque information, resulting in better diagnostics, evaluation and therapy planning. A novel automatic segmentation proposal is described herein; the method relies on a binary morphological object reconstruction to segment the coronary wall in IVUS images. First, a preprocessing followed by a feature extraction block are performed, allowing for the desired information to be extracted. Afterward, binary versions of the desired objects are reconstructed, and their contours are extracted to segment the image. The effectiveness is demonstrated by segmenting 1300 images, in which the outcomes had a strong correlation to their corresponding gold standard. Moreover, the results were also corroborated statistically by having as high as 92.72% and 91.9% of true positive area fraction for the lumen and media adventitia border, respectively. In addition, this approach can be adapted easily and applied to other related modalities, such as intravascular optical coherence tomography and intravascular magnetic resonance imaging.


international conference of the ieee engineering in medicine and biology society | 2007

Managing Medical Images and Clinical Information: InCor's Experience

Sergio Shiguemi Furuie; M.S. Rebelo; Ramon Alfredo Moreno; Marcelo dos Santos; Nivaldo Bertozzo; G. H. M. B. Motta; Fabio Antero Pires; Marco Antonio Gutierrez

Patients usually get medical assistance in several clinics and hospitals during their lifetime, archiving vital information in a dispersed way. Clearly, a proper patient care should take into account that information in order to check for incompatibilities, avoid unnecessary exams, and get relevant clinical history. The Heart Institute (InCor) of Satildeo Paulo, Brazil, has been committed to the goal of integrating all exams and clinical information within the institution and other hospitals. Since InCor is one of the six institutes of the University of Satildeo Paulo Medical School and each institute has its own information system, exchanging information among the institutes is also a very important aspect that has been considered. In the last few years, a system for transmission, archiving, retrieval, processing, and visualization of medical images integrated with a hospital information system has been successfully created and constitutes the InCors electronic patient record (EPR). This work describes the experience in the effort to develop a functional and comprehensive EPR, which includes laboratory exams, images (static, dynamic, and three dimensional), clinical reports, documents, and even real-time vital signals. A security policy based on a contextual role-based access control model was implemented to regulate users access to EPR. Currently, more than 10 TB of digital imaging and communications in medicine (DICOM) images have been stored using the proposed architecture and the EPR stores daily more than 11 GB of integrated data. The proposed storage subsystem allows 6 months of visibility for rapid retrieval and more than two years for automatic retrieval using a jukebox. This paper addresses also a prototype for the integration of distributed and heterogeneous EPR


Journal of Digital Imaging | 2009

Proposal for DICOM Multiframe Medical Image Integrity and Authenticity

Luiz Octavio Massato Kobayashi; Sergio Shiguemi Furuie

This paper presents a novel algorithm to successfully achieve viable integrity and authenticity addition and verification of n-frame DICOM medical images using cryptographic mechanisms. The aim of this work is the enhancement of DICOM security measures, especially for multiframe images. Current approaches have limitations that should be properly addressed for improved security. The algorithm proposed in this work uses data encryption to provide integrity and authenticity, along with digital signature. Relevant header data and digital signature are used as inputs to cipher the image. Therefore, one can only retrieve the original data if and only if the images and the inputs are correct. The encryption process itself is a cascading scheme, where a frame is ciphered with data related to the previous frames, generating also additional data on image integrity and authenticity. Decryption is similar to encryption, featuring also the standard security verification of the image. The implementation was done in JAVA, and a performance evaluation was carried out comparing the speed of the algorithm with other existing approaches. The evaluation showed a good performance of the algorithm, which is an encouraging result to use it in a real environment.


Clinics | 2009

Assessing the scientific research productivity of a Brazilian healthcare institution: a case study at the heart institute of São Paulo, Brazil

Beatriz Helena Tess; Sergio Shiguemi Furuie; Regina Célia Figueiredo Castro; Maria do Carmo Cavarette Barreto; Moacyr Roberto Cuce Nobre

INTRODUCTION: The present study was motivated by the need to systematically assess the research productivity of the Heart Institute (InCor), Medical School of the University of São Paulo, Brazil. OBJECTIVE: To explore methodology for the assessment of institutional scientific research productivity. MATERIALS AND METHODS: Bibliometric indicators based on searches for author affiliation of original scientific articles or reviews published in journals indexed in the databases Web of Science, MEDLINE, EMBASE, LILACS and SciELO from January 2000 to December 2003 were used in this study. The retrieved records were analyzed according to the index parameters of the journals and modes of access. The number of citations was used to calculate the institutional impact factor. RESULTS: Out of 1253 records retrieved from the five databases, 604 original articles and reviews were analyzed; of these, 246 (41%) articles were published in national journals and 221 (90%) of those were in journals with free online access through SciELO or their own websites. Of the 358 articles published in international journals, 333 (93%) had controlled online access and 223 (67%) were available through the Capes Portal of Journals. The average impact of each article for InCor was 2.224 in the period studied. CONCLUSION: A simple and practical methodology to evaluate the scientific production of health research institutions includes searches in the LILACS database for national journals and in MEDLINE and the Web of Science for international journals. The institutional impact factor of articles indexed in the Web of Science may serve as a measure by which to assess and review the scientific productivity of a research institution.


brazilian symposium on computer graphics and image processing | 2002

Visualizing inner structures in multimodal volume data

Isabel Harb Manssour; Sergio Shiguemi Furuie; Sílvia Delgado Olabarriaga; Carla Maria Dal Sasso Freitas

With the evolution of medical image acquisition techniques, the capacity and fidelity of image-based diagnosis were extended. The current trend is to acquire information using multiple sources to help medical diagnosis, but the integration of the multivariate data into a single 3D representation is non-trivial. Techniques for the visualization of multimodal volume data have been developed with the goal of finding suitable strategies to integrate characteristics of multiple data sets into a single visual representation. Likewise, several techniques are dedicated to the exploration of different ways of incorporating seeing-through capabilities into volume rendering techniques. This paper presents a new approach to visualize inner structures in multimodal volume data, which is based in the utilization of cutting tools.


Medical Imaging 2002: Physiology and Function from Multidimensional Images | 2002

Assessment of carotid diameter and wall thickness in ultrasound images using active contours improved by a multiresolution technique

Marco Antonio Gutierrez; Paulo Eduardo Pilon; Silvia G. Lage; Liliane Kopel; Ricardo T Carvalho; Sergio Shiguemi Furuie

Carotid vessel ultrasound imaging is a reliable non-invasive technique to measure the arterial morphology. Vessel diameter, intima-media thickness (IMT) of the far wall and plaque presence can be reliably determined using B-mode ultrasound. In this paper we describe a semi-automatic approach to measure artery diameter and IMT based on an active contour technique improved by a multiresolution analysis. The operator selects a region-of-interest (ROI) in a series of carotid images obtained from B-mode ultrasound. This set of images is convolved with the corresponding partial derivatives of the Gaussian filter. The filter response is used to compute a 2D gradient magnitude image in order to refine the vessels boundaries. Using an active contour technique the vessels border is determined automatically. The near wall media-adventitia (NWMA), far wall media-adventitia (FWMA) and far wall lumen-intima (FWLI) borders are obtained by a least-square fitting of the active contours result. The distance between NWMA and FWLI (vessel diameter) and between FWLI and FWMA (far wall intima-media thickness) are obtained for all images and the mean value is computed during systole and diastole. The proposed method is a reliable and reproducible way of assessing the vessel diameter and far wall intima-media thickness of the carotid artery.

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M.S. Rebelo

University of São Paulo

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Fernando Mitsuyama Cardoso

Instituto Tecnológico de Aeronáutica

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Pedro A. Lemos

University of São Paulo

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C.P. Melo

University of São Paulo

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