Setsuko Ohta

各種生薬メタノールエキスのラットα-Naphthylisothiocyanate(ANIT)肝障害防護効力

Sixty seven methanol extracts of crude drugs were examined for their effects to protect hepatic injury induced by alpha-naphthylisothiocyanate (ANIT) in rats. In terms of the release of intrahepatic enzymes and bilirubin into the serum, 19 extracts were found to suppress the increase in the concentration of serum bilirubin by ANIT. Out of the 19 extracts those of Berchemia Racemosa Caulis, Aurantii Nobilis Pericarpium, Polygoni Avicularis Herba and Gentianae Scabrae Radix, also inhibited the release of several intrahepatic enzymes used as parenchymal injury parameter.

放射線障害防護薬剤に関する研究(第27報)放射線障害に対する各種漢方方剤のメタノールエキスの延命効果

The survival effect of mice irradiated with a lethal dose of X-ray was studied by use of 60 kinds of Chinese traditional medicines. Methanol extracts of these medicines were prepared, and then each extract injected intraperitoneally into male mice before or after whole-body irradiation. As a result of these studies, the survival effects with Ogi-kentyu-to, Simotu-to, Sessyo-in, Zokumei-to and Boi-ogi-to were observed by intraperitoneal injection before irradiation. Of these effective methanol extracts, only Zokumei-to was shown to have a significant survival effect by intraperitoneal injection after irradiation.

Comparative Studies on Lactase Preparations

Comparisons of enzymatic activities of five commercial lactase preparations were made in terms of the sensory tests of such properties as appearance, smell and taste.β-Galactosidase activities were different among preparations, and the activity was found to be higher or lower than the labelled activity of the respective preparations. Stability of the enzyme activity at various temperatures and pH was also different among preparations. Marcked characteristics of other enzymes contained were also shown in the potency test and sensory test.