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American Journal of Ophthalmology | 1979

The Inhibition of Corneal Vascularization with Aortic Extracts in Rabbits

Reuben Eisenstein; Seymour B. Goren; Barbara Shumacher; Earl Choromokos

A low molecular weight fraction of bovine aortic extract inhibited corneal vascularization and edema in rabbits when administered either subconjunctivally or topically as long as 48 hours after injury. The extract also appeared to enhance the regression of newly formed corneal vessels. Topical administration for as long as two months had no deleterious ocular side effects. Tissue culture experiments showed that analagous fractions prepared from bovine vitreous inhibit endothelial cell growth. The major growth inhibitor of corneal neovascularization was not the Kunitz bovine protease inhibitor.


American Journal of Ophthalmology | 1967

Retinal Edema Secondary to Oral Contraceptives

Seymour B. Goren

This report presents 2 cases of retinal lesions which disappeared with cessation of oral contraceptives reappeared when the medication was resumed and again regressed when therapy was stopped. The first case a 21-year-old patient complained of blurriness of vision in her right eye of 3-weeks duration. She had been taking C-Quens for 1 month for dysmenorrhea. Examination found a 1 disc-diameter retinal edema in the right eye and a scotoma. C-Quens were discontinued and no other therapy given. After 3 weeks symptoms had diappeared and the retina was normal. After resuming C-Quens for 2 weeks the blurriness recurred. Retinal edema was again present in the same area as before and a similar scotoma was present. The drug was discontinued after 2 weeks symptoms disappeared and all retinal findings were normal. Permanent avoidance of C-Squens was recommended. A 26-year-old patient who had received 50 mg daily of Enovid for 13 months for dymenorrhea complained of blurred vision in her right eye of 2 weeks duration. An area of retinal edema was found and a small scotoma was present. The Enovid was discontinued and within 10 days findings were normal. Enovid was restarted within another 10 days symptoms reappeared; it was stopped within a week findings were normal. Later the patient took another oral contraceptive (Ortho-Novum). After 3 months ophthalmoscopy showed normal fundi. Results are considered presumptive evidence that the retinal findings were due to the oral contraceptive involved.


American Journal of Ophthalmology | 1977

The Inhibition of Corneal Vascularization in Rabbits

Seymour B. Goren; Reuben Eisenstein; Earl Choromokos

A single subconjunctival injection of 250 microgram of a partially purified extract of bovine aorta, administered immediately before or after silver nitrate injury to the cornea, markedly inhibited corneal vascularization in the rabbit eye. We believe the active molecule is a protease inhibitor that prevents the potential source of new vessels from proliferating and invading the diseased cornea.


American Journal of Ophthalmology | 1966

Blowout Fractures of the Orbital Floor

Seymour B. Goren; Raymond B. Strauss; Donald B. Osbon

Six patients with blowout fractures of the orbital floor, not associated with infraorbital rim fractures, are presented. Diplopia, infraorbital anesthesia and enophthalmos following blunt trauma to the eye should alert the examiner to the possibility of a blowout fracture with incarceration of extraocular tissues. Early roentgenographic examinations are often difficult to evaluate because of periorbital edema, mucosal swelling and antral hematoma. In cases in which stereoscopic Waters projections are equivocal, laminograms of the orbit, after the edema subsides, will aid in confirming the diagnosis. Forced ductions will often ascertain whether or not there is impingement of extraocular tissues in the fracture site. If there is no clinical evidence of incarceration or impingement of extraocular tissues, but only radiographic suggestion of a blowout fracture, there is a possibility that surgical intervention may be deferred and the patient carefully watched. However, early recognition and treatment of soft tissue incarcerations is necessary in order to avoid persistent diplopia, enopththalmos, and late cosmetic deformity.


Postgraduate Medicine | 1975

The Red Eye

Seymour B. Goren

The appearance of the conjunctival circulation is a basic consideration in the differential diagnosis of the red eye. The causes of the red eye are myriad, commonly including subconjunctival hemorrhage, acute conjunctivitis, and acute angle-closure glaucoma.


Postgraduate Medicine | 1975

Eye disorders: common ocular injuries: assessing the severity.

Seymour B. Goren

Any eye injruy due to blunt trauma calls for a measurement of visual acuity as part of the initial examination. Blunt trauma may result in a black eye or in a far more serious injury such as blowout fracture, hyphema, or macular edema.


Postgraduate Medicine | 1969

Ocular toxicity of commonly used systemic drugs.

Seymour B. Goren

The eye a complex organ with multiple enzyme systems often reflect s untoward side effects of drugs. Retinal edema associated with a visual field defect and blurring of vision has been reported in patients using oral contraceptives. Cataract formation in patients receiving long-term steroid therapy has been reported. Discontinuing the steroid avoids progress of the cataracts. Rise in intraocular pressure and decr eased resistance to infection may also occur with steroid therapy. Topical application of steroid drops or ointment to the eye is dangerous especially when herpes simplex keratitis is present. Ocular problems found with tranquilizers phenothiazide digitalis chloroquine and belladonna alkaloids are also detailed.


American Journal of Ophthalmology | 1975

Cataract associated with long-term facial paralysis.

Seymour B. Goren

Of 29 patients with postoperative acoustic neuroma, five patients with facial paralysis developed unilateral lens opacities of unknown etiology on the paralyzed side, one to six years after surgery. The corneas were well maintained in all patients by means of either eyelid surgery or flush-fitting scleral contact shells. Four patients had anterior subcapsular opacities and in one patient a mature cataract developed. Thus, cataracts may be associated with long-term facial paralysis.


Postgraduate Medicine | 1972

Tearing Problems in the Elderly

Seymour B. Goren

The elderly patient may experience excessive tearing (epiphora) or a deficiency of tears. Epiphora usually results from impaired lacrimal outflow due to inflammation, foreign bodies, concretions or scarring. Treatment depends on the etiology. A deficiency of tears is generally due either to specific conjunctival disease or to deficient lacrimal secretion, such as in keratoconjunctivitis sicca. Instillation of drops or ointment often is helpful. Surgical treatment may be necessary.


American Journal of Ophthalmology | 1961

The Localization of Diamox-S35 in the Rabbit Eye

Seymour B. Goren; Frank W. Newell; John J. O'Toole

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