Shabnam Javdani

Serotonin transporter gene associations with psychopathic traits in youth vary as a function of socioeconomic resources.

Although prior research has examined the genetic correlates of antisocial behavior, molecular genetics influences on psychopathic traits remain largely unknown. Consequently, we investigated the influence of polymorphic variation at the serotonin transporter protein gene (SLC6A4) and socioeconomic resources (SES) on psychopathic traits in youth across two distinct samples in two separate studies. In Study 1, a main effect of serotonin transporter (5-HTTLPR) genotype was associated with the impulsivity dimension of psychopathy. That is, individuals homozygous for the short allele evidenced more impulsivity than did those homozygous for the long allele. In contrast, a gene-environment interaction was associated with the callous-unemotional and narcissistic features of psychopathy. Callous-unemotional and narcissistic traits increased as SES decreased only among youths with the homozygous-long (l/l) genotype, a novel finding replicated and extended in Study 2. These studies provide preliminary results that the l/l genotype confers risk for the emotional deficits and predatory interpersonal traits associated with psychopathy among youths raised in disadvantaged environments.

Borderline personality disorder as a female phenotypic expression of psychopathy

Evidence suggests that the combination of the interpersonal-affective (F1) and impulsive-antisocial (F2) features of psychopathy may be associated with borderline personality disorder (BPD), specifically among women (e.g., Coid, 1993; Hicks, Vaidyanathan, & Patrick, 2010). However, empirical research explicitly examining gendered relationships between BPD and psychopathy factors is lacking. To further inform this area of research, we investigated the hypothesis that the interplay between the two psychopathy factors is associated with BPD among women across two studies. Study 1 consisted of a college sample of 318 adults (51% women), and Study 2 consisted of a large sample of 488 female prisoners. The interpersonal-affective (F1) and impulsive-antisocial psychopathy (F2) scores, measured with self-report and clinician-rated indices, respectively, were entered as explanatory variables in regression analyses to investigate their unique contributions to BPD traits. Across two independent samples, results indicated that the interaction of high F1 and F2 psychopathy scores was associated with BPD in women. This association was found to be specific to women in Study 1. These results suggest that BPD and psychopathy, at least as they are measured by current instruments, overlap in women and, accordingly, may reflect gender-differentiated phenotypic expressions of similar dispositional vulnerabilities.

Suicidality as a Function of Impulsivity, Callous-Unemotional Traits, and Depressive Symptoms in Youth

Suicidality represents one of the most important areas of risk for adolescents, with both internalizing (e.g., depression, anxiety) and externalizing-antisocial (e.g., substance use, conduct) disorders conferring risk for suicidal ideation and attempts (e.g., Bridge, Goldstein, & Brent, 2006). However, no study has attended to gender differences in relationships between suicidality and different facets of psychopathic tendencies in youth. Further, very little research has focused on disentangling the multiple manifestations of suicide risk in the same study, including behaviors (suicide attempts with intent to die, self-injurious behavior) and general suicide risk marked by suicidal ideation and plans. To better understand these relationships, we recruited 184 adolescents from the community and in treatment. As predicted, psychopathic traits and depressive symptoms in youth showed differential associations with components of suicidality. Specifically, impulsive traits uniquely contributed to suicide attempts and self-injurious behaviors, above the influence of depression. Indeed, once psychopathic tendencies were entered in the model, depressive symptoms only explained general suicide risk marked by ideation or plans but not behaviors. Further, callous-unemotional traits conferred protection from suicide attempts selectively in girls. These findings have important implications for developing integrative models that incorporate differential relationships between (a) depressed mood and (b) personality risk factors (i.e., impulsivity and callous-unemotional traits) for suicidality in youth.

Gender Differences in Emotional Risk for Self- and Other-Directed Violence among Externalizing Adults.

OBJECTIVE Women and men generally differ in how frequently they engage in other- and self-directed physical violence and may show distinct emotional risk factors for engagement in these high-impact behaviors. To inform this area, we investigated gender differences in the relationship of emotional tendencies (i.e., anger, hostility, and anhedonic depression) that may represent risk for other-directed violence (i.e., physical fighting, attacking others unprovoked) and self-directed violence (i.e., self-injury, suicide attempts). METHOD The ethnically diverse sample consisted of 372 adults (252 men and 120 women age 18-55) with a history of criminal convictions. Facets of emotional risk assessed with the Aggression Questionnaire (Buss & Warren, 2000) and Mood and Anxiety Symptom Questionnaire (Watson et al., 1995) were entered simultaneously as explanatory variables in regression analyses to investigate their unique contributions to other- and self-directed physical violence in men and women. RESULTS Analyses revealed that anhedonic depressive tendencies negatively predicted other-directed violence and positively predicted self-directed violence in men and women, consistent with a model of depression in which aggression is turned inward (Henriksson et al., 1993). Gender differences, however, emerged for the differential contributions of anger and hostility to other- and self-directed violence. Trait anger (i.e., difficulty controlling ones temper) was associated with other-directed violence selectively in men, whereas trait hostility (i.e., suspiciousness and alienation) was associated with self- and other-directed violence among women. CONCLUSIONS The divergent findings for trait anger and hostility underscore the need to examine gender-specific risk factors for physical violence to avoid excluding potentially useful clinical features of these mental health outcomes.

Gender and Factor-Level Interactions in Psychopathy: Implications for Self-Directed Violence Risk and Borderline Personality Disorder Symptoms

Women with antisocial and psychopathic traits have a more extensive history of self-directed violence, as well as borderline personality disorder (BPD) symptoms, than their male counterparts (Chapman, Specht, & Cellucci, 2005; Warren et al., 2003). To inform this area of research, we examined gender differences in the relationship between psychopathy factors and risk for self-directed violence, as measured by a history of suicidal ideation, self-harm, and suicide attempts, across 2 studies. In both studies, we found that the interaction of the interpersonal-affective (Factor 1) and impulsive-antisocial traits (Factor 2) of psychopathy, a combination considered to exemplify high psychopathy, was associated with ideation, self-harm, and suicide attempt histories specifically in women. In men, Factor 2 traits were associated with these risk indices for self-directed violence, regardless of Factor 1. In Study 2, we extended our analysis to examine whether BPD accounted for the relationship between psychopathy and self-directed violence differentially in women and men. Results suggested that BPD symptoms partially accounted for the effects of Factor 2 on self-directed violence (both self-harm and attempts) in both genders but fully accounted for Factor 1 protective effects only in men. These findings underscore the notion that the same psychopathic trait liabilities, at least as they are currently assessed, may confer risk for different forms of behavioral maladjustment in women versus men.

Dimensions of Adolescent Psychopathology and Relationships to Suicide Risk Indicators

Youth suicide represents an area of important public and mental health concern. Although diagnostic correlates (e.g., depression) of suicidality have been identified, very few studies of youth have analyzed relationships between empirically-derived dimensions of psychopathology, representing broader dimensions of risk, and different suicidality indicators. We recruited 223 adolescents (57% female; 32% ethnic minority) from mental health agencies and the community to assess psychopathology, substance use, and suicidality relying on multiple measures and reporters (youth, parent, and clinician). Using a 3-factor model of psychopathology, we found that the Internalizing factor (including depression and generalized anxiety) was associated with both suicidal thinking and behaviors (threats/attempts), the Externalizing factor (conduct, oppositional, and attention deficit disorders) was negatively related only to suicidal thinking, and the Substance Use factor (alcohol and cannabis use) related to suicidal behaviors of threats/attempts but not suicidal thinking. The results show the utility of a dimensional conceptualization for clarifying distinct vulnerabilities to suicidal thinking versus overt behaviors and have implications for the construct validity of distinct dimensions of psychopathology.

Examining psychopathic tendencies in adolescence from the perspective of personality theory.

This study sought to clarify the personality correlates of psychopathic tendencies in adolescents using the Antisocial Process Screening Device [APSD; Frick and Hare, 2001] and a youth adapted version of the Multidimensional Personality Questionnaire [Patrick et al., 2009, unpublished]. A combination of self- and parent-reports on the APSD (n=229) revealed that the three-facet model of psychopathic tendencies in youth was characterized by a similar constellation of personality traits as the psychopathic construct in adulthood [e.g., Hall, Benning and Patrick, 2004]. Specifically, low anxiety and trait aggression characterized the APSD Callous/Unemotional dimension, social dominance and trait aggression characterized the APSD Narcissism dimension, and disinhibition and low harm avoidance characterized the APSD Impulsivity dimension. The results add credence to the hypothesis that personality relationships to psychopathic tendencies emerge from an early age [Lynam, 2002] and dimensions of psychopathy in youth are associated with distinct personality profiles.

Analysis of monoaminergic genes, childhood abuse, and dimensions of psychopathy.

Psychopathy is a multidimensional construct characterized by an interpersonally manipulative and emotionally detached personality profile that differentiates it from other antisocial syndromes. Previous research with youth has linked the long allele of the serotonin transporter gene in the presence of environmental stress with the interpersonal and affective traits of psychopathy, but these relationships have yet to be examined in relation to adult psychopathy. Consequently, we examined how serotonin transporter (5-HTTLPR) polymorphisms, monoamine oxidase-A (MAO-A) variants, and childhood abuse measured with the Childhood Trauma Questionnaire relate to dimensions of psychopathy in a forensic sample of 237 men with elevated levels of environmental adversity. We found that the emotional deficits characterizing the affective factor of psychopathy, as measured by the Psychopathy Checklist: Screening Version, were highest among carriers of the 5-HTT long allele. Furthermore, the impulsive and irresponsible lifestyle features of psychopathy were higher among low-activity than high-activity MAO-A carriers. These genetic effects were unexpectedly not moderated by a history of childhood abuse. Results provide evidence on the molecular genetics correlates of psychopathic traits in adulthood, relationships that should be investigated further in future research.

“Changing the Text”: Modeling Council Capacity to Produce Institutionalized Change

Collaboration is a ubiquitous approach to change, but is notoriously difficult and not definitively linked to desirable outcomes. Not surprisingly, the collaboration literature is replete with numerous facilitators and barriers to collaborative efforts. The current study aimed to develop a parsimonious model of factors influencing the success of collaborative efforts both internal and external to the council, including, (a) features of the council environment, (b) intermediate outcomes including the empowerment of members in the council context and the degree to which councils have generated social capital and (c) the extent to which collaborative efforts are occurring in a community context supportive of their aims. In particular, this study examines whether these factors affect the extent to which councils are positioned to achieve institutionalized change, or changes “in the text” that govern front line providers’ (e.g., police, advocates) practices in the community response to intimate partner violence. Results suggest that perceived member empowerment, generation of social capital, and supportive community context are the most important predictors of the extent to which councils foster shifts in institutionalized change. Features of the council environment are only indirectly related to the degree to which institutionalized change is ultimately fostered as mediated by the generation of social capital. This suggests that the ability of members to act as change agents and the extent to which those in power support council efforts figure more prominently to facilitate or constrain council efforts than council functioning itself.

Proximal Outcomes Matter: A Multilevel Examination of the Processes by Which Coordinating Councils Produce Change

Communities are engaged in efforts to create a coordinated response to intimate partner violence. Though coordinating councils are commonly employed vehicles for such efforts, research provides only equivocal support regarding their effectiveness. These mixed findings may reflect methodological and conceptual challenges. Specifically, there is an over-reliance on conceptualizing council effectiveness in terms of distal outcomes (e.g., behavior change), rather than the intermediary processes by which councils affect change. A direct assessment of councils’ proximal outcomes may highlight change mechanisms. To that end, this study investigates the extent to which councils impact proximal outcomes and examines the processes through which proximal outcomes are interrelated and linked to distal community change. Study findings suggest that perceived proximal outcomes do significantly predict variability in perceived distal community change across councils. Specifically, promotion of social capital and institutionalized change predict achievement of distal community change, and promotion of social capital also predicts achievement of institutionalized change.