Shadeed Gad

Effect of Antiadherents on the Physical and Drug Release Properties of Acrylic Polymeric Films

Antiadherents are used to decrease tackiness of a polymer coating during both processing and subsequent storage. Despite being a common excipient in coating formulae, antiadherents may affect mechanical properties of the coating film as well as drug release from film-coated tablets, but how could addition of antiadherents affect these properties and to what extent and is there a relation between the physical characteristics of the tablet coat and the drug release mechanisms? The aim of this study was to evaluate physical characteristics of films containing different amounts of the antiadherents talc, glyceryl monostearate, and PlasACRYLTM T20. Eudragit RL30D and Eudragit RS30D as sustained release polymers and Eudragit FS30D as a delayed release material were used. Polymer films were characterized by tensile testing, differential scanning calorimetry (DSC), microscopic examination, and water content as calculated from loss on drying. The effect of antiadherents on in vitro drug release for the model acetylsalicylic acid tablets coated with Eudragit FS30D was also determined. Increasing talc concentration was found to decrease the ability of the polymer films to resist mechanical stress. In contrast, glyceryl monostearate (GMS) and PlasACRYL produced more elastic films. Talc at concentrations higher than 25% caused negative effects, which make 25% concentration recommended to be used with acrylic polymers. All antiadherents delayed the drug release at all coating levels; hence, different tailoring of drug release may be achieved by adjusting antiadherent concentration with coating level.

Optimization of Gabapentin Release and Targeting Absorption, Through Incorporation into Alginate Beads

Aims: 1) To study the effect of some formulation variables on drug load, encapsulation efficiency, swelling ratio, mucoadhesion and drug release. 2) Optimize the mucoadhesion capabilities for targeting drug absorption and releasecontrolling capabilities of algi nate beads. Methodology: Alginatebeads were prepared by dripping sodium alginate gel into calcium chloride solution and then dried overnight at ambient temperature. The effects of alginate concentration, cross linker concentration, cross linking time, vol

Diclofenac-induced Gastric Ulceration in Rats: Protective Roles of Pantoprazole and Misoprostol

Gastrointestinal damage caused by diclofenac remains a significant clinical problem. Pantoprazole provides potent and long-lasting inhibition of gastric acid secretion and has proven efficacy in healing diclofenac-associated ulcers, including those with continued exposure to diclofenac. The objective of this study was to prepare and evaluate microbeads of diclofenac sodium coated with sodium alginate and Hydroxypropylmethylcellulose (HPMC) in order to obtain controlled release drug delivery system. The ulcerogenic activity and histopathological effects of the prepared formulation were compared with a marked formula containing the drug with misoprostol which orally administered to male Wistar rats. Ionotropic gelation technique was the technique of choice to encapsulate the drug. IR spectral analysis indicated no interaction between the drug and polymers used. Microbeads which showed a significant reduction in the release of diclofenac at acidic pH of Original Research Article El-Deen et al.; BJPR, 11(3): 1-12, 2016; Article no.BJPR.24636 2 the stomach as well as maximal release at alkaline pH of the intestine were selected to conduct further in vivo evaluation. The beads were administered to rats in combination with pantoprazole. The obtained ulcer index as well as the histopathological effects of the proposed formulations was compared to marketed formula containing the drug combined with misoprostol. The obtained in vivo results indicate that administration of pantoprazole and diclofenac microbeads has shown efficacy in reducing the risk of GIT ulcerations compared with administration of misoprostol and diclofenac or diclofenac separately.

Simple Controlled Release Delivery System for an Anti-hypertensive Drug via Buccal Route

Objective: This study aims to develop controlled release buccal tablets of losartan potassium based on bioadhesion using direct compression technique. Materials and Methods: The bioadhesive buccal tablets of losartan potassium were prepared after preliminary drug -excipients compatibility studies and micromeretics study for powder blends. The tablets were prepared by direct compression utilizing carbopol 934LR as a primary bioadhesive polymer either with or without chitosan or hydroxypropyl methylcellulose E15LV as secondary polymers. Other excipients included PVP K30 as a binder, magnesium stearate as a lubricant and mannit ol as a diluent. The tablets were evaluated for weight variation, thickness and diameter, hardness, friability, drug content, surface pH,Ex-vivoresidence time and bioadhesion force,In-vitroswelling anddrug release study.The analysis of the release pr ofiles in the light of distinct kinetic models