Shafik Khoury
Tel Aviv University
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Publication
Featured researches published by Shafik Khoury.
Chest | 2017
Zach Rozenbaum; Shafik Khoury; Galit Aviram; Yaniv Gura; Jack Sherez; Avi Man; Jason Shimiaie; Thierry Le Tourneau; Amir Halkin; Simon Biner; Gad Keren; Yan Topilsky
Background: Discriminating circulatory problems with reduced stroke volume (SV) from deconditioning, in which the muscles cannot consume oxygen normally, by gas exchange parameters is difficult. Methods: We performed combined stress echocardiography (SE) and cardiopulmonary exercise tests (CPET) in 110 patients (20 with normal effort capacity, 54 with attenuated SV response, and 36 with deconditioning) to evaluate multiple hemodynamic parameters and oxygen content difference (A‐Symbolo2 Diff) in four predefined activity levels to assess which of the gas measures may help in the discrimination. Symbol. No caption available. Results: Reduced anaerobic threshold (AT), low unchanging peak oxygen pulse, periodic breathing, shallow &Dgr; peak oxygen consumption (Symbolo2)/&Dgr;work rate (WR) ratio, and high expired volume per unit time/carbon dioxide production (Symbole/Symbolco2) slope were all associated with abnormal SV response (P < .05 for all). The best discriminator was Symbole/Symbolco2 slope to Symbolo2 ratio (≥ 2.7; area under the curve [AUC], 0.79; P < .0001). The optimal gas exchange model included &Dgr;Symbolo2/&Dgr;WR < 8.6; Symbole/Symbolco2 slope to peak Symbolo2 ratio ≥ 2.7, and periodic breathing (AUC of 0.84; P < .0001). Symbol. No caption available. Symbol. No caption available. Symbol. No caption available. Symbol. No caption available. Symbol. No caption available. Symbol. No caption available. Symbol. No caption available. Symbol. No caption available. Symbol. No caption available. Symbol. No caption available. Conclusions: The best single gas exchange parameter to discriminate between circulatory problems and deconditioning is Symbole/Symbolco2 slope to peak SymbolO2 ratio. Combining it with &Dgr;Symbolo2/&Dgr;WR and periodic breathing improves the discriminative ability. Symbol. No caption available. Symbol. No caption available. Symbol. No caption available. Symbol. No caption available.
European heart journal. Acute cardiovascular care | 2017
Gilad Margolis; Amir Gal-Oz; Shafik Khoury; Gad Keren; Yacov Shacham
Background: Acute kidney injury is associated with adverse outcomes after acute ST elevation myocardial infarction (STEMI). It remains unclear, however, whether subclinical increase in serum creatinine that does not reach the consensus criteria for acute kidney injury is also related to adverse outcomes in STEMI patients undergoing primary percutaneous coronary intervention. Methods: We conducted a retrospective study of 1897 consecutive STEMI patients between January 2008 and May 2016 who underwent primary percutaneous coronary intervention, and in whom acute kidney injury was not diagnosed throughout hospitalization. We investigated the incidence of subclinical acute kidney injury (defined as serum creatinine increase of ≥ 0.1 and < 0.3 mg/dl) and its relation to a composite end point of adverse in hospital outcomes. Results: Subclinical acute kidney injury was detected in 321 patients (17%). Patients with subclinical acute kidney injury had increased rate of the composite end point of adverse in-hospital events (20.3% vs. 9.7%, p<0.001), a finding which was independent of baseline renal function. Individual components of this end point (occurrence of heart failure, atrial fibrillation, need for mechanical ventilation and in-hospital mortality) were all significantly higher among patients with subclinical acute kidney injury (p< 0.05 for all). In a multivariable regression model subclinical acute kidney injury was independently associated with higher risk for adverse in-hospital events (odds ratio 1.92.6, 95% confidence interval: 1.23–2.97, p=0.004). Conclusions: Among STEMI patients treated with primary percutaneous coronary intervention, small, subclinical elevations of serum creatinine, while not fulfilling the consensus criteria for acute kidney injury, may serve as a significant biomarker for adverse outcomes.
CardioRenal Medicine | 2017
Gilad Margolis; Shahar Vig; Nir Flint; Shafik Khoury; Michael Barkagan; Gad Keren; Yacov Shacham
Background: Limited data is present regarding long-term outcomes in chronic kidney disease (CKD) patients presenting with stent thrombosis (ST). We evaluated the possible implications of CKD on long-term mortality in patients presenting with ST-segment elevation myocardial infarction (STEMI) and treated with primary percutaneous coronary intervention (PCI), and its interaction with the presence of ST. Methods: We retrospectively studied 1,722 STEMI patients treated with primary PCI. Baseline CKD was categorized as an estimated glomerular filtration rate <60 mL/min/1.73 m2 at presentation. The presence of ST was determined using the Academic Research Consortium definitions. Patients were evaluated for the presence of CKD and ST, as well as for long-term mortality. Results: A total of 448/1,722 (26%) patients had baseline CKD. Patients with CKD were older and had more comorbidities and a higher rate of ST (4 vs. 7%, respectively, p < 0.001). In a univariate analysis, long-term mortality was significantly higher among those with CKD compared to those without CKD (17.6 vs. 2.7%, p < 0.001). The presence of ST did not alter long-term mortality in both CKD and no-CKD patients. In a Cox regression model, CKD was an independent predictor of long-term mortality (hazard ratio 2.04, 95% confidence interval 1.17-3.56, p = 0.01), while ST as a covariate was not significantly associated with long-term mortality. Conclusion: Among STEMI patients, CKD, but not ST, is a predictor of long-term mortality.
Journal of the American College of Cardiology | 2017
Shafik Khoury; Sarit Carmon; Gilad Margolis; Gad Keren; Yacov Shacham
Background: Since the advent of primary percutaneous coronary intervention (PCI) for the treatment of ST-elevation myocardial infarction (STEMI), studies have reported a declining incidence of left ventricular thrombus (LVT) following STEMI. The majority of LVT were found prior to hospital discharge
Clinical Research in Cardiology | 2017
Shafik Khoury; Sarit Carmon; Gilad Margolis; Gad Keren; Yacov Shacham
Journal of Nephrology | 2018
Gilad Margolis; Amir Gal-Oz; Sevan Letourneau-Shesaf; Shafik Khoury; Gad Keren; Yacov Shacham
Acta Neurologica Belgica | 2014
Ronit Nesher; Michael Mimouni; Shafik Khoury; Gideon Nesher; Ori Segal
American Journal of Cardiology | 2017
Yan Topilsky; Zach Rozenbaum; Shafik Khoury; Gregg S. Pressman; Yaniv Gura; Jack Sherez; Avi Man; Jason Shimiaie; Sanford Edwards; Joshua Berookhim; Thierry Le Tourneau; Amir Halkin; Simon Biner; Gad Keren; Galit Aviram
International Journal of Cardiology | 2018
Zach Rozenbaum; Yan Topilsky; Shafik Khoury; David Pereg; Michal Laufer-Perl
Coronary Artery Disease | 2018
Yoav Preisler; Tomer Ziv-Baran; Ehud Chorin; Gilad Margolis; Shafik Khoury; Yacov Shacham