Shahin Fatma

Nucleophilic heterocyclic carbene promoted one pot multicomponent synthesis of new 6-(1H-indol-3-yl)-2-oxo-4-aryl-1,2,3,4 tetrahydropyrimidine-5-carbonitriles: an eco-compatible approach with PEG as a biodegradable medium

A three-component, one-pot, simple, direct and highly efficient cyclocondensation method has been developed for the synthesis of fourteen 6-(1H-indol-3-yl)-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidine-5-carbonitriles by combining an arylaldehyde with 3-(cyanoacetyl)-indoles and urea in the presence of the PEG-400 and a catalytic amount of the thiazolium anion. A short reaction time, simple reaction conditions, ease of product isolation, use of a cheap and readily available and reusable catalyst make this method very attractive from an environmental and economic perspective.

Development of five membered heterocyclic frameworks via [3+2] cycloaddition reaction in an aqueous micellar system

A series of novel dihydropyrrolo[2,1-a]isoquinolines and dihydropyrrolo[1,2-a]quinolines have been synthesized from isoquinolines/quinolines, various substituted phenacyl bromides and substituted dialkylacetylenedicarboxylates via [3+2] cycloaddition reaction. The reaction proceeds in aqueous micellar medium with DBU as a catalyst. The present protocol offers a simple one pot sequential reaction affording products in excellent yields.

Nucleophilic, Heterocyclic, Carbene-Catalyzed, Solvent-Free, One-Pot Synthesis of Polyhydroquinolines via Multicomponent Hantzsch Reaction: An Efficient and Ecofriendly Approach

Abstract A simple, efficient, and ecofriendly one-pot method has been reported for the synthesis of polyhydroquinolines in excellent yield using nucleophilic heterocyclic carbene as catalyst. The generalized approach is the Hantzsch four-component reaction of aromatic aldehyde, ethyl acetoacetate, cyclic 1,3-diketone, and ammonium acetate. GRAPHICAL ABSTRACT

Microwave-Induced Solvent-Free Synthesis and Antifungal Screening of Novel Spiro Heterocyclic Systems Containing 3,5-Diphenyl-7H-thiazolo[3,2-a]pyrimidine and Indolin-2-one

Abstract A microwave-induced technique has been developed for the synthesis of a series of novel spiro indoline-based heterocycles (7a–g) at atmospheric pressure in an open vessel using an environmentally benign procedure. This rapid method produces pure products in good yields within a few minutes in comparison to the conventional procedure developed for the synthesis of these heterocycles. The synthesized compounds have been screened in vitro for antifungal activity against two fungal strains (i.e., Aspergillus niger and Aspergillus flavus). All compounds have shown significant activity against these pathogens. [Supplementary materials are available for this article. Go to the publishers online edition of Synthetic Communications® for the following free supplemental resource: Full experimental and spectral details.] GRAPHICAL ABSTRACT

Triphenylphosphine-Catalyzed, Novel, One-Pot, Multicomponent Synthesis of Functionalized β-Acetamido Carbonyls

Abstract An efficient triphenylphosphine-catalyzed synthesis of β-acetamido carbonyls via multicomponent reaction of aromatic aldehydes, enolizable ketones or β-keto esters, acid chlorides and acetonitrile at room temperature is described. The process is remarkably simple, environmentally benign, and uses Lewis base for the first time in such type of reaction. GRAPHICAL ABSTRACT

Novel, versatile and eco-compatible preparation of new 6-(1 H -indol-3-yl)-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidine-5-carbonitriles in water

A three-component, one-pot, simple and direct, highly efficient cyclocondensation method has been developed for the synthesis of 11 6-(1H-indol-3-yl)-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidine-5-carbonitriles by combining an araldehyde with 3-(cyanoacetyl)-indole and urea in the presence of the cationic surfactant, CTAB and a catalytic amount of thiamine hydrochloride in water. A short reaction time, simple reaction conditions, ease of product isolation, and use of a cheap and readily available reusable catalyst make this method very attractive from an environmental and economic perspective.