Shailesh B. Raval

Design and fabrication of a realistic anthropomorphic heterogeneous head phantom for MR purposes

Objective The purpose of this study is to design an anthropomorphic heterogeneous head phantom that can be used for MRI and other electromagnetic applications. Materials and methods An eight compartment, physical anthropomorphic head phantom was developed from a 3T MRI dataset of a healthy male. The designed phantom was successfully built and preliminarily evaluated through an application that involves electromagnetic-tissue interactions: MRI (due to it being an available resource). The developed phantom was filled with media possessing electromagnetic constitutive parameters that correspond to biological tissues at ~297 MHz. A preliminary comparison between an in-vivo human volunteer (based on whom the anthropomorphic head phantom was created) and various phantoms types, one being the anthropomorphic heterogeneous head phantom, were performed using a 7 Tesla human MRI scanner. Results Echo planar imaging was performed and minimal ghosting and fluctuations were observed using the proposed anthropomorphic phantom. The magnetic field distributions (during MRI experiments at 7 Tesla) and the scattering parameter (measured using a network analyzer) were most comparable between the anthropomorphic heterogeneous head phantom and an in-vivo human volunteer. Conclusion The developed anthropomorphic heterogeneous head phantom can be used as a resource to various researchers in applications that involve electromagnetic-biological tissue interactions such as MRI.

Dual optimization method of radiofrequency and quasistatic field simulations for reduction of eddy currents generated on 7T radiofrequency coil shielding

To optimize the design of radiofrequency (RF) shielding of transmit coils at 7T and reduce eddy currents generated on the RF shielding when imaging with rapid gradient waveforms.

Ultra‐high‐field RF coil development for evaluating upper extremity imaging applications

The purpose of this study is to develop and evaluate a custom‐designed 7 T MRI coil and explore its use for upper extremity applications.

RF System for Ultra-High Field Upper Extremity Imaging.

INTRODUCTION: Imaging extremities in MR is an invaluable, non-invasive method widely used in orthopedic, hand surgery, post-transplant evaluation, variety of pathologic hand conditions.1 In order to address soft-tissue related challenges, UHF-MR imaging is the precise imaging tool which provides high signal/contrast-to-noise ratio (S/CNR), higher anatomic resolution, and reduced scan time.2 Due to the small electrical size (filling-factor) of the arm/hand, we use a TEM resonator in conjunction with eight channels receive (Rx)-onlyinsert array rather than the multi-channel transmit or transceiver approach at 7T.

Ultra-high field upper extremity peripheral nerve and non-contrast enhanced vascular imaging

Objective The purpose of this study was to explore the efficacy of Ultra-high field [UHF] 7 Tesla [T] MRI as compared to 3T MRI in non-contrast enhanced [nCE] imaging of structural anatomy in the elbow, forearm, and hand [upper extremity]. Materials and method A wide range of sequences including T1 weighted [T1] volumetric interpolate breath-hold exam [VIBE], T2 weighted [T2] double-echo steady state [DESS], susceptibility weighted imaging [SWI], time-of-flight [TOF], diffusion tensor imaging [DTI], and diffusion spectrum imaging [DSI] were optimized and incorporated with a radiofrequency [RF] coil system composed of a transverse electromagnetic [TEM] transmit coil combined with an 8-channel receive-only array for 7T upper extremity [UE] imaging. In addition, Siemens optimized protocol/sequences were used on a 3T scanner and the resulting images from T1 VIBE and T2 DESS were compared to that obtained at 7T qualitatively and quantitatively [SWI was only qualitatively compared]. DSI studio was utilized to identify nerves based on analysis of diffusion weighted derived fractional anisotropy images. Images of forearm vasculature were extracted using a paint grow manual segmentation method based on MIPAV [Medical Image Processing, Analysis, and Visualization]. Results High resolution and high quality signal-to-noise ratio [SNR] and contrast-to-noise ratio [CNR]—images of the hand, forearm, and elbow were acquired with nearly homogeneous 7T excitation. Measured [performed on the T1 VIBE and T2 DESS sequences] SNR and CNR values were almost doubled at 7T vs. 3T. Cartilage, synovial fluid and tendon structures could be seen with higher clarity in the 7T T1 and T2 weighted images. SWI allowed high resolution and better quality imaging of large and medium sized arteries and veins, capillary networks and arteriovenous anastomoses at 7T when compared to 3T. 7T diffusion weighted sequence [not performed at 3T] demonstrates that the forearm nerves are clearly delineated by fiber tractography. The proper digital palmar arteries and superficial palmar arch could also be clearly visualized using TOF nCE 7T MRI. Conclusion Ultra-high resolution neurovascular imaging in upper extremities is possible at 7T without use of renal toxic intravenous contrast. 7T MRI can provide superior peripheral nerve [based on fiber anisotropy and diffusion coefficient parameters derived from diffusion tensor/spectrum imaging] and vascular [nCE MRA and vessel segmentation] imaging.

Upper Extremity Ultra-High Field MR Imaging of Bilateral Hand Transplant Patient: Case Report (VCA).

RESULTS: Surgery was completed without skin grafting in nine cases of 14 web spaces; two of them were complex/complete, and two of them were simple/complete syndactylies. We used a skin graft in one patient because of triangular flap necrosis in a second operation. The use of a bilobed flap allowed the construction of web spaces, providing satisfactory cosmetic outcomes (figure 1 2). No partial necrosis or complications were observed in bilobed flaps. Operation time is shorter than the classical technique which needs to use a skin graft. Also, it is possible to reconstruct multiple webs in the same patient with this flap.

Exploring Peripheral Nerve, Macro and Micro-Vasculature Imaging Applications at Ultra-High Field MRI.

CONCLUSION: Stimulation current thresholds to evoke CSNAPs were similar between DSIs and native skin. Elicitation of CSNAPs was reliable even at high stimulation frequencies. Varying the stimulation current applied to DSIs produced differential CSNAP potentials characteristic of native afferent signaling amplitudes. These fi ndings suggest that patterned electrical stimulation can be successfully transduced across DSIs to produce graded sensory feedback.

Correction: Design and fabrication of a realistic anthropomorphic heterogeneous head phantom for MR purposes

[This corrects the article DOI: 10.1371/journal.pone.0183168.].

A new RF transmit coil for foot and ankle imaging at 7T MRI

A four-channel Tic-Tac-Toe (TTT) transmit RF coil was designed and constructed for foot and ankle imaging at 7T MRI. Numerical simulations using an in-house developed FDTD package and experimental analyses using a homogenous phantom show an excellent agreement in terms of B1+ field distribution and s-parameters. Simulations performed on an anatomically detailed human lower leg model demonstrated an B1+ field distribution with a coefficient of variation (CV) of 23.9%/15.6%/28.8% and average B1+ of 0.33μT/0.56μT/0.43μT for 1W input power (i.e., 0.25W per channel) in the ankle/calcaneus/mid foot respectively. In-vivo B1+ mapping shows an average B1+ of 0.29μT over the entire foot/ankle. This newly developed RF coil also presents acceptable levels of average SAR (0.07W/kg for 10g per 1W of input power) and peak SAR (0.34W/kg for 10g per 1W of input power) over the whole lower leg. Preliminary in-vivo images in the foot/ankle were acquired using the T2-DESS MRI sequence without the use of a dedicated receive-only array.

2563: Non-contrast enhanced 7 tesla MR imaging for non-invasive monitoring of chronic rejection in reconstructive transplantation

2563: Non-contrast enhanced 7 tesla MR imaging for non-invasive monitoring of chronic rejection in reconstructive transplantation Shailesh Raval, MS, Tiejun Zhao, PhD, Narayan Krishnamurthy, Tamer Ibrahim, PhD, and Vijay S. Gorantla, MD, PhD University of Pittsburgh, Pittsburgh, PA, USA; Siemens Healthineers, Malvern, PA, USA Introduction Chronic rejection (CR) in solid organ and reconstructive transplantation (RT) is associated with progressive, occlusive intimal hyperplasia (IH) resulting in ischemic graft loss Four hand transplants and 1 face transplant have been lost to CR Skin biopsies can detect acute rejection (AR) but miss CR changes Early detection is key to prevent CR graft loss Sequential vascular mapping with CT angiography is fraught with radiation/contrast risks and intravascular imaging is invasive or lead to graft ischemia For the first time, we developed a non-invasive, reliable and reproducible, non-radiation, contrast-free, ultra-high resolution (UHR) 3D vascular MRI imaging strategy for preoperative (surgical planning) and perioperative (graft viability) and post-transplant (CR monitoring) applications in RT. Results Our non-contrast technique allowed UHR luminal and vessel wall imaging in the CF and UE tissues Volume-rendering and post-processing allowed successful 3D-reconstruction and segmenting micro/macrovasculature of CF and UE without skeletonization or dilation Figure 1 summarizes T1-VIBE, T2-DESS and DSI revealing exquisite detail of soft tissue anatomy (vessels, muscles, nerve, fat, ligaments, and tendons). Conclusion Current state of the art imaging in RT includes conventional imaging (3D-CT, 15/3TMRI, CT-angio, intravascular-ultrasound, plain-radiography) and stereolithography for surgical planning with limitation like radiation, renal toxic contrast or are of sub-optimal resolution to map microvessels /other structures Our approach is renal-toxic-contrast and radiationfree, increasing its safety in RT (CF or UE) or even solid organ (eg renal transplant) applications for sequential non-invasive graft monitoring of CR In addition, UHR imaging can be used for monitoring of neuroregeneration after transection/repair or transplant related nerve outcomes as well as identifying precise localization of various structures for patient screening/selection, procedural planning and sequential monitoring of macro/microvascular parameters. CONTACT Shailesh Raval, MS rshailesh8504@gmail.com Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/kvca.