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Dive into the research topics where Sharmin Jahan is active.

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Featured researches published by Sharmin Jahan.


Nature plants | 2017

Comparative genomics of two jute species and insight into fibre biogenesis

Shahidul Islam; Jennifer A. Saito; Emdadul Mannan Emdad; Borhan Ahmed; Mohammad Moinul Islam; Abdul Halim; Quazi Md Mosaddeque Hossen; Zakir Hossain; Rasel Ahmed; Sabbir Hossain; Shah Md Tamim Kabir; Sarwar Alam Khan; Mursalin Khan; Rajnee Hasan; Nasima Aktar; Ummay Honi; Rahin Islam; Mamunur Rashid; Xuehua Wan; Shaobin Hou; Taslima Haque; Muhammad Shafiul Azam; Mahdi Muhammad Moosa; Sabrina M. Elias; A. M. Mahedi Hasan; Niaz Mahmood; Shafiuddin; Saima Shahid; Nusrat Sharmeen Shommu; Sharmin Jahan

Jute (Corchorus sp.) is one of the most important sources of natural fibre, covering ∼80% of global bast fibre production1. Only Corchorus olitorius and Corchorus capsularis are commercially cultivated, though there are more than 100 Corchorus species2 in the Malvaceae family. Here we describe high-quality draft genomes of these two species and their comparisons at the functional genomics level to support tailor-designed breeding. The assemblies cover 91.6% and 82.2% of the estimated genome sizes for C. olitorius and C. capsularis, respectively. In total, 37,031 C. olitorius and 30,096 C. capsularis genes are identified, and most of the genes are validated by cDNA and RNA-seq data. Analyses of clustered gene families and gene collinearity show that jute underwent shared whole-genome duplication ∼18.66 million years (Myr) ago prior to speciation. RNA expression analysis from isolated fibre cells reveals the key regulatory and structural genes involved in fibre formation. This work expands our understanding of the molecular basis of fibre formation laying the foundation for the genetic improvement of jute.


American Journal of Medical Case Reports | 2018

A Novel Mutation in FGF23 Causing Severe Manifestation of Hyperphosphataemic Familial Tumoral Calcinosis

Tania Tofail; Fariduddin M; Tahniyah Haq; Shahjada Selim; Sharmin Jahan; Khan Ma; Marufa Mustari; Hurjahan Banu; Datta Nk; Islam Ma; Hossain Ms; Hasanat Ma

We present a 16-year girl, second issue of a consanguineous couple presented with painless symmetrical bony swellings around hips for 3 years. She lost 25 kg weight due to profound anorexia in the first year of illness and developed secondary amenorrhea. Last 7 months she had repeated generalized tonic clonic seizure due to hypocalcaemia. The bony swellings were located in both gluteal regions and were 30x35 cm2, hard and non tender. Mobility of hip joints were restricted. Except for severe wasting as a part of generalized cachexia other systemic examination was unremarkable. Investigations revealed anaemia (Hb-E trait), low albumin, low corrected calcium (during convulsions) otherwise normal, persistently high phosphate & vitamin-D level, normal iPTH & alkaline phosphatase (ALP), low serum ascorbic acid, normal ESR & CRP. X-ray & CT scan of pelvis showed large calcified mass in periarticular soft tissues. Biopsy confirmed presence of dystrophic calcification. Diagnosis of tumoral calcinosis was based on biochemical parameters, imaging and biopsy findings. A homozygous novel mutation in FGF homology domain: B-21 mutated from G to A at 232 in exon 2. As a result glutamic acid is replaced by lysine. Phosphate restricted diet and phosphate lowering agent improved biochemical paramaters. Surgical excision has been withheld. Contemporary manifestation of hFTC and Hb E trait; two disease of autosomal recessive inheritance in an individual makes it extremely rare. High index of suspicion is needed for early diagnosis and treatment.


American Journal of Medical Case Reports | 2018

Bartter Syndrome: A Rare Renal Tubulopathy Presenting with Polyuria, Generalized Weakness and Recurrent Tetany in an Adolescent Male

Satyajit Mallick; Hasanat Ma; Fariduddin M; Tahseen Mahmood; Mohona Zaman; Sharmin Jahan

Bartter syndrome is a rare autosomal recessive renal tubulopathy resulting in hypokalemic, hypochloremic metabolic alkalosis with hyperreninemia. It consists of a set of closely related overlapping syndromes having variable presentation. Advances in molecular diagnostics have revealed the underlying mutations in numerous genes that affect the function of ion channels and transporters which normally mediate salt reabsorption in the distal nephron segments. The classic manifestations are childhood onset of fatigue, polyuria, polydipsia, salt craving, vomiting, dehydration, short stature, and failure to thrive. It should be suspected in any young, normotensive individual presenting with persistent hypokalemic alkalosis in the absence of surreptitious diuretic abuse. It requires high index of clinical suspicion for appropriate diagnosis and timely treatment have been shown to reverse the clinical and biochemical abnormalities thereby improve the outcome. Here we report a 19-year-old boy with classical Bartter syndrome that was treated with Potassium supplementation, NSAID, spironolactone and he showed significant improvement on subsequent follow-up.


American Journal of Medical Case Reports | 2016

Laron Syndrome: Siblings with Extreme Short Stature and Very High Growth Hormone

Sharmin Jahan; Hasanat Ma; Nusrat Sultana; Shadequl-Islam Ahm; Satyajit Mallick; Saifur-Rahman M; Fariduddin M

Primary growth hormone resistance or growth hormone insensitivity syndrome (GHIS), also known as Laron syndrome, is a hereditary disease caused by deletions or different types of mutations in the growth hormone receptor gene or by post-receptor defects. This disorder is characterized by a clinical appearance attributable to severe growth hormone deficiency with high levels of circulating growth hormone in contrast to low serum insulin-like growth factor-1 (IGF-1) and low serum insulin-like growth factor binding protein (IGFBP-3)values. It is an autosomal recessive disorder and to date, more than 70 unique growth hormone receptor (GHR) mutations have been identified in more than 250 GHIS patients. We report the case of an 8-year-old boy and his 12-year-old sister born to first cousin parent that presented with severe short stature who had the classic feature of GH deficiency. Investigations revealed high plasma GH levels in both the cases. Subsequently, IGF-1 and IGFBP-3 assay were done and the levels were found to be very low. These reports along with elevated GH level in the context of typical picture of GH deficiency confirmed the diagnosis of GHIS. Genetic testing could not be done because of unavailability in our context. Regrettably specific therapy in the form of recombinant IGF-1 could not be offered as it is not commercially available in our country.


Journal of Clinical Diabetology | 2016

Alarming Frequency of Gestational Diabetes Mellitus (GDM) Attending a Tertiary Care Hospital in Bangladesh

Urman A Dhruv; Om Prakash Gupta; Nusrat Sultana; Hasanat Ma; Sharmin Jahan; Mashfiqul Hasan; Sandesh Panthi; Yasmin Aktar; Fariduddin M


Bangabandhu Sheikh Mujib Medical University Journal | 2016

Fine needle aspiration cytological diagnosis of thyroid nodule with its clinical correlation

M. Q. Hassan; Hasanat Ma; Fariduddin M; M. S. Emran; Marufa Mustari; Sharmin Jahan; Nusrat Sultana; Nurjahan Banu; Sunil Kumar Biswas; M. Rafiqul Alam; Mohammed Kamal


AACE clinical case reports | 2018

Metastatic medullary thyroid carcinoma with normal serum calcitonin levels: a case report

Tania Tofail; Fariduddin M; Tahniyah Haq; Shahjada Selim; Sharmin Jahan; Morshed Ahmed Khan; Marufa Mustari; Hurjahan Banu; Rafiqul Alam; Aminul Islam Joarder; Mohammed Kamal; Muhammad Abul Hasanat


Journal of National Institute of Neurosciences Bangladesh | 2017

Plasmapheresis in the Treatment of Neurologic Disorders in Bangladesh: A Review Update

Sharmin Jahan; Mohammad Enayet Hussain; Badrul Alam; Quazi Deen Mohammad


Integrative Obesity and Diabetes | 2016

TCF7L2 gene rs7903146 polymorphism is observed in gestational diabetes mellitus in Bangladesh

Mashfiqul Hasan; Hasanat Ma; Nadim-Hasan K; Sandesh Panthi; Yasmin Aktar; Nusrat Sultana; Sharmin Jahan; Atiqur-Rahman M; Ashish Kumar Mazumder; Khaleque M A; Fariduddin M; Sharif Akhteruzzaman


Bangabandhu Sheikh Mujib Medical University Journal | 2016

Empty sella syndrome presenting as panhypopituitarism in a child

Sharmin Jahan; Masfiq-Ul Hasant; Nusrat Sultana; Md. Fariduddin; Mohammad Enayet Hussain; Hasanat Ma

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Fariduddin M

Bangabandhu Sheikh Mujib Medical University

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Hasanat Ma

Bangabandhu Sheikh Mujib Medical University

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Nusrat Sultana

Bangabandhu Sheikh Mujib Medical University

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Marufa Mustari

Bangabandhu Sheikh Mujib Medical University

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Hurjahan Banu

Bangabandhu Sheikh Mujib Medical University

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Mohammad Enayet Hussain

Dhaka Medical College and Hospital

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Mohammed Kamal

Bangabandhu Sheikh Mujib Medical University

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Shahjada Selim

Bangabandhu Sheikh Mujib Medical University

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Tahniyah Haq

Bangabandhu Sheikh Mujib Medical University

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