Sharon Maynard
Beth Israel Deaconess Medical Center
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Publication
Featured researches published by Sharon Maynard.
Journal of Clinical Investigation | 2003
Sharon Maynard; Jiang Yong Min; Jaime R. Merchan; Kee-Hak Lim; Jianyi Li; Susanta Mondal; Towia A. Libermann; James P. Morgan; Frank W. Sellke; Isaac E. Stillman; Franklin H. Epstein; Vikas P. Sukhatme; S. Ananth Karumanchi
Preeclampsia, a syndrome affecting 5% of pregnancies, causes substantial maternal and fetal morbidity and mortality. The pathophysiology of preeclampsia remains largely unknown. It has been hypothesized that placental ischemia is an early event, leading to placental production of a soluble factor or factors that cause maternal endothelial dysfunction, resulting in the clinical findings of hypertension, proteinuria, and edema. Here, we confirm that placental soluble fms-like tyrosine kinase 1 (sFlt1), an antagonist of VEGF and placental growth factor (PlGF), is upregulated in preeclampsia, leading to increased systemic levels of sFlt1 that fall after delivery. We demonstrate that increased circulating sFlt1 in patients with preeclampsia is associated with decreased circulating levels of free VEGF and PlGF, resulting in endothelial dysfunction in vitro that can be rescued by exogenous VEGF and PlGF. Additionally, VEGF and PlGF cause microvascular relaxation of rat renal arterioles in vitro that is blocked by sFlt1. Finally, administration of sFlt1 to pregnant rats induces hypertension, proteinuria, and glomerular endotheliosis, the classic lesion of preeclampsia. These observations suggest that excess circulating sFlt1 contributes to the pathogenesis of preeclampsia.
The New England Journal of Medicine | 2004
Richard J. Levine; Sharon Maynard; Cong Qian; Kee-Hak Lim; Lucinda England; Kai F. Yu; Enrique F. Schisterman; Ravi Thadhani; Benjamin P. Sachs; Franklin H. Epstein; Baha M. Sibai; Vikas P. Sukhatme; S. Ananth Karumanchi
Annual Review of Medicine | 2008
Sharon Maynard; Franklin H. Epstein; S. Ananth Karumanchi
Kidney International | 2005
S. Ananth Karumanchi; Sharon Maynard; Isaac E. Stillman; Franklin H. Epstein; Vikas P. Sukhatme
American Journal of Obstetrics and Gynecology | 2006
Richard J. Levine; Cong Qian; Sharon Maynard; Kai F. Yu; Franklin H. Epstein; S. Ananth Karumanchi
Archive | 2003
Ananth Karumanchi; Sharon Maynard; Vikas P. Sukhatme
Archive | 2008
S. Ananth Karumanchi; Sharon Maynard; Vikas P. Sukhatme
Archive | 2008
S. Ananth Karumanchi; Sharon Maynard; Vikas P. Sukhatme
/data/revues/00029378/v193i6sS/S0002937805015401/ | 2011
Richard U. Levine; Chun Lam; Cong Qian; Kai Yu; Sharon Maynard; Baha Sibai; Roberto Romero; Franklin H. Epstein; Ananth Karumanchi
Molecular and Genetic Basis of Renal Disease#R##N#A Companion to Brenner & Rector's The Kidney | 2008
Sharon Maynard; S. Ananth Karumanchi